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Novel tissue repair film

A technology of tissue repair and film sticking, applied in medical science, prosthesis, additive processing, etc., can solve the problems of limited cell sheet thickness, uneven arrangement of myotubes, inconvenient implantation of harvested cell sheets, etc., and improve the effect of tissue repair , scar tissue reduction, promotion of differentiation and polar growth effects

Inactive Publication Date: 2019-09-06
HUNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The use of tissue engineering to construct tissue repair patches in vitro is very meaningful and in line with clinical needs, but there are many limitations in previous studies, such as the limited thickness of cell sheets manufactured by two-dimensional Disadvantages such as misalignment and inconvenient harvesting of cell sheets for implantation

Method used

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Embodiment Construction

[0022] Below in conjunction with implementing regulation this patent is described further.

[0023] 1) Manufacturing method of three-layer novel tissue repair film

[0024] Outer layer: The magnetic patch and bacterial cellulose are bonded with tissue adhesive.

[0025] Middle layer: bacterial cellulose. Obtained by culturing Acetobacter xylinum in acetic acid bacteria medium (#350). The bacterial cellulose membrane is firstly rinsed with clean water, then boiled with 1% NaOH until the solution is clear, and finally soaked in ultrapure water until weakly alkaline or neutral. Soak in 75% medical alcohol for 10 minutes, and irradiate with ultraviolet light for 1 hour to sterilize.

[0026] Inner layer: ordered fiber filaments. Prepare 7% (v / v) polycaprolactone (PCL) and collagen (1%) printing solutions, and attach them to bacterial cellulose membranes by 3D printing and other rapid prototyping methods to obtain polycaprolactone ordered fibers. Soak in 75% medical alcohol fo...

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Abstract

The invention relates to the field of tissue engineering and regenerative medicine and designs a novel trilayer tissue repair film by constructing collagen-modified single-row high-molecular ordered fibers and bacterial cellulose and modifying the finished film with a static magnetic field generated by an added magnetic patch. An inner layer of the tissue repair film is made with the collagen-modified single-row high-molecular ordered fibers based on the action of fiber morphology upon cell behaviors, so that a binding site is provided for cells, and polar growth of the cells is induced. An intermediate layer is made with the bacterial cellulose, so that cell penetration is facilitated and a survival space is preserved for the cells. an outermost layer is made with the magnetic patch; thestatic magnetic field generated by the magnetic patch can produce a series of biological effects upon cells of living things. The novel trilayer tissue repair film is used mainly to regenerate skin tissue and repair skeletal muscular tissue. Based on structural optimization, the novel trilayer tissue repair film can be applied to tissue wounds, so that collected cells are regulated through the collagen-modified single-row high-molecular ordered fibers. finally, the behaviors of different cells in different tissue repair phases can be regulated through the series of biological effects which theapplied added magnetic field produces for the cultured cells.

Description

technical field [0001] Aiming at the fields of tissue engineering and regenerative medicine, the present invention uses collagen-modified single-row polymer ordered fiber and bacterial cellulose to prepare artificial tissue repair patch, and utilizes the magnetic field generated by the magnetic patch to make cells produce a series of favorable biological effects , can be used for the regeneration and repair of skin and muscle tissue. Collagen-modified single-row polymer ordered fibers can simulate the hierarchical structure of biological tissues and provide cells with binding sites suitable for growth, so that they have a uniform orientation, reduce scar tissue, and improve tissue repair effects. The additional magnetic field has various effects such as inducing cell polar growth and differentiation, accelerating wound healing and repair, and can promote the fusion of myoblasts, so that myoblasts can differentiate into myotubes and muscle fibers while promoting the angiogenic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/24A61L27/18A61L27/50B33Y70/00
CPCA61L27/18A61L27/20A61L27/24A61L27/50A61L2300/412B33Y70/00C08L1/02C08L67/04
Inventor 谭志凯王小成
Owner HUNAN UNIV
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