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Traditional Chinese medicine gel plaster for relieving pain and preparation method thereof

A technology of traditional Chinese medicine and gel, which is applied in the direction of medical formula, non-central analgesics, antipyretics, etc. It can solve the problems of non-existent analgesic traditional Chinese medicine gel, and achieve the improvement of drug stability, integrity maintenance, and good coagulation strength Effect

Inactive Publication Date: 2019-09-13
郁光雷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no pain-relieving traditional Chinese medicine gel with Uncaria as main component in the prior art.

Method used

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  • Traditional Chinese medicine gel plaster for relieving pain and preparation method thereof
  • Traditional Chinese medicine gel plaster for relieving pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] An analgesic Chinese medicine gel patch, comprising the following components in parts by weight:

[0052] 4 parts traditional Chinese medicine extractant, 2 parts stabilizer, 0.5 parts absorbent, 3.5 parts sodium carboxymethyl cellulose, 3.5 parts cellulose nanocrystals and 0.2 parts calcium nitrate;

[0053] The raw material of the traditional Chinese medicine extractant is composed of 6 parts by weight of Uncaria, 5 parts of Uncaria, 1 part of Juncus and 1 part of dianthus.

[0054] The steps of the preparation method of the Chinese medicine extract are as follows:

[0055] S1. Grind Uncaria, Uncaria, Rush, Dianthus, and sieve 50 meshes to obtain traditional Chinese medicine powder. Use n-hexane as the extractant to reflux at 75°C for 5 hours in a Soxhlet extractor. Take the solid at 75°C. Dry for 2 hours to obtain skim powder;

[0056] The mass ratio of the traditional Chinese medicine powder and n-hexane is 1:8;

[0057] S2. The defatted powder is refluxed in a Soxhlet extrac...

Embodiment 2

[0072] An analgesic Chinese medicine gel patch, comprising the following components in parts by weight:

[0073] 4 parts traditional Chinese medicine extractant, 2 parts stabilizer, 0.5 parts absorbent, 3.5 parts sodium carboxymethyl cellulose, 3.5 parts modified cellulose nanocrystals and 0.2 parts calcium nitrate;

[0074] The raw material of the traditional Chinese medicine extractant is composed of 6 parts by weight of Uncaria, 5 parts of Uncaria, 1 part of Juncus and 1 part of dianthus.

[0075] The steps of the preparation method of the Chinese medicine extract are as follows:

[0076] S1. Grind Uncaria, Uncaria, Rush, Dianthus, and sieve 50 meshes to obtain traditional Chinese medicine powder. Use n-hexane as the extractant to reflux at 75°C for 5 hours in a Soxhlet extractor. Take the solid at 75°C. Dry for 2 hours to obtain skim powder;

[0077] The mass ratio of the traditional Chinese medicine powder and n-hexane is 1:8;

[0078] S2. The defatted powder is refluxed in a Soxhl...

Embodiment 3

[0096] An analgesic Chinese medicine gel patch, comprising the following components in parts by weight:

[0097] 4 parts traditional Chinese medicine extractant, 2 parts stabilizer, 0.5 parts absorbent, 3.5 parts sodium carboxymethyl cellulose, 3.5 parts modified cellulose nanocrystals and 0.2 parts calcium nitrate;

[0098] The raw material of the traditional Chinese medicine extractant is composed of 6 parts by weight of Uncaria, 5 parts of Uncaria, 1 part of Juncus and 1 part of dianthus.

[0099] The steps of the preparation method of the Chinese medicine extract are as follows:

[0100] S1. Grind Uncaria, Uncaria, Rush, Dianthus, and sieve 50 meshes to obtain traditional Chinese medicine powder. Use n-hexane as the extractant to reflux at 75°C for 5 hours in a Soxhlet extractor. Take the solid at 75°C. Dry for 2 hours to obtain skim powder;

[0101] The mass ratio of the traditional Chinese medicine powder and n-hexane is 1:8;

[0102] S2. The defatted powder is refluxed in a Soxhl...

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Abstract

The invention provides a traditional Chinese medicine gel plaster for relieving pain and a preparation method thereof, and belongs to the field of medical configuration products. The provided gel plaster includes a traditional Chinese medicine extractant, a stabilizer, an absorbent, a sodium carboxymethylcellulose, cellulose nanocrystal and inorganic calcium salt; the traditional Chinese medicineextractant consists of ramulus uncariae cum uncis, mitragyna inermis, common rush and lilac pink herb; the stabilizer consists of cucurbituril and animal protein; and the absorbent is an acylated rutin / chitosan compound. The main component of the provided gel plaster is alkaloid, the most representative of the gel plaster is rhynchophylline, and the 24-hour skin permeation rate of the rhynchophylline can reach up to 35.38%; and the provided gel also has good mechanical properties, and the fracture stress can reach up to 240.4 kPa.

Description

Technical field [0001] The invention belongs to the field of medical preparations, in particular to an analgesic traditional Chinese medicine gel patch and a preparation method thereof. Background technique [0002] Uncaria has sweet and bitter taste, slightly cold in nature, and has the effects of clearing heat, calming liver, extinguishing wind and pain, and lowering blood pressure. Returning to the liver and pericardium, the 2010 edition of the Pharmacopoeia of the People's Republic of China records that the authentic Uncaria include: Uncaria uncaria, Uncaria macrophylla, Uncaria hystrix, Uncaria serrata and Uncaria sessileum. Clinical pharmacological studies have shown that the traditional Chinese medicine Uncaria has a definite effect on hypertension, headache, dizziness and so on. Plants of this genus contain indole alkaloids, triterpenoids and flavonoids and other chemical components, of which indole alkaloids are the main effective part. Studies have shown that Uncaria ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/70A61K47/42A61K47/22A61K47/36A61K47/38A61P29/00
CPCA61K9/7023A61K36/36A61K36/74A61K36/88A61K47/22A61K47/36A61K47/38A61K47/42A61K2236/333A61K2236/35A61K2236/51A61P29/00A61K2300/00
Inventor 郁光雷
Owner 郁光雷
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