Egg yolk-eggshell type UCNP@MgSiO3 nanoparticle preparation method
A nanoparticle, eggshell-type technology is applied in the field of preparation of egg yolk-eggshell-type UCNP@MgSiO3 nanoparticles, which can solve the problems of limited biological treatment and imaging effects, low drug loading efficiency, and limited carrying space, etc. Grooming ability and loading efficiency, overcoming loading inefficiency, effect of good repeatability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0040] Preparation of UCNP@MgSiO with 10 nm thick shell 3 , including the following steps:
[0041] Step 1: Coating UCNP with a silica shell (UCNP@SiO 2 ): take 3.6 mL of n-hexanol, 3.6 mL of triton, and 14 mL of cyclohexane and stir until clear, then add 680 μL of water and mix well; then take 10 mg of synthesized NaYF4:Tm / Yb nanoparticles and disperse them into 2 mL of cyclohexane alkane solution, and sonicate for 10 min; mix the two solutions and stir for 20 min, add 25 μL TEOS (tetraethyl orthosilicate), stir for 20 min, add 40 μL ammonia water, and stir for 20 h. The resulting solution was centrifuged at 6000 rpm for 10 min, the precipitate was washed twice with ethanol, and dispersed in 5 mL of water.
[0042] The prepared UCNP@SiO2 silica shell thickness is 10 nm, figure 1UCNP@SiO as a silica shell 2 Transmission electron microscope image (TEM).
[0043] Step 2: Hydrothermal etching of UCNP@SiO 2 into UCNP@MgSiO3: take the UNCP@SiO synthesized in step 1 2 1 mL o...
Embodiment 2
[0045] Preparation of UCNP@MgSiO with 15 nm thick shell 3 , including the following steps:
[0046] Step 1: Coating UCNP with a silica shell (UCNP@SiO 2 ): take 3.6 mL of n-hexanol, 3.6 mL of triton, and 14 mL of cyclohexane and stir until clear, then add 680 μL of water and mix well; then take 10 mg of synthesized NaYF4:Tm / Yb nanoparticles and disperse them into 2 mL of cyclohexane The alkane solution was sonicated for 10 min; the two solutions were mixed and stirred for 20 min, 50 μL TEOS was added, stirred for 20 min, 80 μL ammonia water was added, and stirred for 20 h. The resulting solution was centrifuged at 6000 rpm for 10 min, the precipitate was washed twice with ethanol, and dispersed in 5 mL of water.
[0047] The thickness of the prepared UCNP@SiO2 silica shell is 15 nm, figure 2 UCNP@SiO as a silica shell 2 Transmission electron microscope image (TEM).
[0048] Step 2: Hydrothermal etching of UCNP@SiO 2 into UCNP@MgSiO3: take the UNCP@SiO synthesized in st...
Embodiment 3
[0050] Preparation of UCNP@MgSiO with a shell thickness of 20 nm 3 , including the following steps:
[0051] Step 1: Coating UCNP with a silica shell (UCNP@SiO 2 ): take 3.6 mL of n-hexanol, 3.6 mL of triton, and 14 mL of cyclohexane and stir until clear, then add 680 μL of water and mix well; then take 10 mg of synthesized NaYF4:Tm / Yb nanoparticles and disperse them into 2 mL of cyclohexane The alkane solution was sonicated for 10 min; the two solutions were mixed and stirred for 20 min, 75 μL TEOS was added, stirred for 20 min, 120 μL ammonia water was added, and stirred for 20 h. The resulting solution was centrifuged at 6000 rpm for 10 min, the precipitate was washed twice with ethanol, and dispersed in 5 mL of water.
[0052] The thickness of the prepared UCNP@SiO2 silica shell is 20 nm, image 3 UCNP@SiO as a silica shell 2 Transmission electron microscope image (TEM).
[0053] Step 2 Hydrothermal etching of UCNP@SiO 2 into UCNP@MgSiO 3 : Take the UNCP@SiO synthes...
PUM
| Property | Measurement | Unit |
|---|---|---|
| thickness | aaaaa | aaaaa |
| thickness | aaaaa | aaaaa |
| thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More