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Doxorubicin loaded magnetic PMMA (polymethyl methacrylate) bone cement and preparation method and application thereof

A technology loaded with doxorubicin and bone cement, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of tumor residue, metastasis, recurrence, etc., and achieve reliable mechanical support, good mechanical properties, and satisfactory therapeutic effect

Inactive Publication Date: 2019-09-20
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, hyperthermia is considered to be one of the most effective treatment methods, and hyperthermia usually includes radiofrequency, microwave and high-intensity focused ultrasound, however, these treatment methods may lead to incomplete ablation of bone tumors, and eventually unexpected tumor residual, recurrence and metastasis
While photothermal therapy based on thermal conversion of functional nanoparticles may also lead to tumor cell death, the limitation of light penetration depth severely restricts the application of photothermal therapy.
In addition, the above methods cannot quickly repair bone defects and provide reliable mechanical support for achieving rapid physiological function recovery.

Method used

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  • Doxorubicin loaded magnetic PMMA (polymethyl methacrylate) bone cement and preparation method and application thereof
  • Doxorubicin loaded magnetic PMMA (polymethyl methacrylate) bone cement and preparation method and application thereof
  • Doxorubicin loaded magnetic PMMA (polymethyl methacrylate) bone cement and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Embodiment 1, the preparation of the magnetic PMMA bone cement loaded with doxorubicin of the present invention

[0056] 14.2 g of PMMA powder, 11.7 g of zirconium dioxide powder, and 0.1 g of benzoyl peroxide powder were weighed with a balance, and the above three materials were mixed to obtain 26 g of PMMA mixed powder. 9.2 g of MMA monomer and 0.2 g of N,N-dimethyl-p-toluidine were weighed, and the above two substances were mixed to obtain an MMA mixed liquid. Weigh DOX and Fe 3 o 4 Magnetic nanoparticles, DOX mass is 1% of PMMA mixed powder mass, Fe 3 o 4 The mass of magnetic nanoparticles is 2.5% of the mass of PMMA mixed powder. Mix the above PMMA powder, DOX and Fe by mechanical vibration method 3 o 4 Mixing magnetic nanoparticles to get DOX / Fe 3 o 4 / PMMA mixed powder. DOX / Fe 3 o 4 / PMMA mixed powder mixed with MMA mixed liquid, loaded with DOX and containing 2.5% Fe 3 o 4 The PMMA bone cement slurry of magnetic nanoparticles, the bone cement slurry...

Embodiment 2

[0057] Embodiment 2, the preparation of the magnetic PMMA bone cement loaded with doxorubicin of the present invention

[0058] 14.2 g of PMMA powder, 11.7 g of zirconium dioxide powder, and 0.1 g of benzoyl peroxide powder were weighed with a balance, and the above three materials were mixed to obtain 26 g of PMMA mixed powder. 9.2 g of MMA monomer and 0.2 g of N,N-dimethyl-p-toluidine were weighed, and the above two substances were mixed to obtain an MMA mixed liquid. Weigh DOX and Fe 3 o 4 Magnetic nanoparticles, DOX mass is 1% of PMMA mixed powder mass, Fe 3 o 4 The mass of magnetic nanoparticles is 5% of the mass of PMMA mixed powder. Mix the above PMMA powder, DOX and Fe by mechanical vibration method 3 o 4 Mixing magnetic nanoparticles to get DOX / Fe 3 o 4 / PMMA mixed powder. DOX / Fe 3 o 4 / PMMA mixed powder mixed with MMA mixed liquid, loaded with DOX and containing 5% Fe 3 o 4 The PMMA bone cement slurry of magnetic nanoparticles, the bone cement slurry is ...

Embodiment 3

[0059] Embodiment 3, the preparation of the magnetic PMMA bone cement loaded with doxorubicin of the present invention

[0060] 14.2 g of PMMA powder, 11.7 g of zirconium dioxide powder, and 0.1 g of benzoyl peroxide powder were weighed with a balance, and the above three materials were mixed to obtain 26 g of PMMA mixed powder. 9.2 g of MMA monomer and 0.2 g of N,N-dimethyl-p-toluidine were weighed, and the above two substances were mixed to obtain an MMA mixed liquid. Weigh DOX and Fe 3 o 4 Magnetic nanoparticles, DOX mass is 1% of PMMA mixed powder mass, Fe 3 o 4 The mass of magnetic nanoparticles is 7.5% of the mass of PMMA mixed powder. Mix the above PMMA powder, DOX and Fe by mechanical vibration method 3 o 4 Mixing magnetic nanoparticles to get DOX / Fe 3 o 4 / PMMA mixed powder. DOX / Fe 3 o 4 / PMMA mixed powder mixed with MMA mixed liquid, loaded with DOX and containing 7.5% Fe 3 o 4 The PMMA bone cement slurry of magnetic nanoparticles, the bone cement slurry...

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Abstract

The invention provides doxorubiciin loaded magnetic PMMA (polymethyl methacrylate) bone cement which is formed by mixing and curing of solid and liquid phases. The solid phase is formed by PMMA powder, zirconium dioxide powder, benzoyl peroxide, Ee3O4 nanoparticles and doxorubicin; the liquid phase is formed by an MMA monomer and N,N-dimethyl p-toluidine. The doxorubicin loaded magnetic PMMA bone cement has a good therapeutic effect on bone tumor and completely kill the tumor without recurrence; meanwhile, the metastasis of bone tumor can be effectively inhibited; in addition, the doxorubicin loaded magnetic PMMA bone cement is good in mechanical property, can provide reliable mechanical support for defective bone tissue, is beneficial to the recovery of the bone tissue, and provides satisfactory therapeutic effect.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a magnetic PMMA bone cement loaded with doxorubicin, a preparation method and application thereof. Background technique [0002] Bone tumor is a common tumor with a high mortality rate, which seriously threatens the life of patients. Meanwhile, bone tumors can cause many catastrophic bone-related events, such as unbearable bone pain, pathological fractures, spinal cord compression, bone deformities, and hypercalcemia. In addition, with bone lesions, its supporting force is gradually lost, causing patients to be unable to stand or even lie on the bed. These complications significantly reduce the patient's quality of life, further increasing mortality. Surgical resection is the traditional choice for primary bone tumors. However, huge trauma such as amputation poses a huge physical and mental challenge to patients. Therefore, it is necessary to develop a minimally...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/02A61L27/50A61L27/54
CPCA61L27/025A61L27/16A61L27/50A61L27/54A61L2300/232A61L2300/416A61L2430/02C08L33/12
Inventor 楚磊石磊郑元义杨俊松余柯晓刘文邓瑞邓忠良
Owner THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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