Synthesis method of ethyl N-cyanoethanimideate

A technology of ethyl cyanoethylimidate and ethyl ethylimidate hydrochloride, applied in the direction of organic chemistry, etc., can solve production costs, high energy consumption, difficult to handle by-products, low yield, low purity, etc. problem, to achieve the effect of increasing the content, avoiding inseparability, and simple process steps
CN110256295AInactive Publication Date: 2019-09-20宁夏贝利特生物科技有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
宁夏贝利特生物科技有限公司
Publication Date
2019-09-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthesis method of ethyl N-cyanoethanimideate, and the method comprises the following steps: adding ethyl ethyleneimine hydrochloride into a reaction kettle with stirring, adding a cyanamide aqueous solution under stirring, and stirring until the ethyl ethyleneimine hydrochloride is fully dissolved; dropping an alkaline substance to adjust pH value; allowing the materials to be fully reacted under normal temperature and stirring state, taking samples every 10 min in the reaction process, and detecting the samples by chromatography to determine the conversion rate of the reaction; standing after an aqueous phase and an organic phase in the reactant are layered, extracting the organic phase out and then distilling organic phase the under reduced pressure to obtain an ethyl N-cyanoethanimideate product. The synthesis method is simple and feasible, energy-saving and environment-friendly, solves the problems of complex reaction, pollution and the like in the synthesis process, and saves the cost at the same time.
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Description

technical field

[0001] The invention relates to the technical field of organic synthesis, and more specifically relates to a synthetic method of ethyl N-cyanoethylimidate. Background technique

[0002] Ethyl cyanoate, also known as ethyl cyanoethylimidate, is an important pharmaceutical and pesticide intermediate for the synthesis of insecticides acetamiprid and vitamin B1, as well as an important chemical raw material.

[0003] Many documents in China have described the synthesis of cyanoethyl ester, and the reaction equation of the currently mainly used synthetic cyanoethyl ester is as follows:

[0004]

[0005] The reaction process mainly has the following problems:

[0006] 1. Due to the higher price of the raw material disodium hydrogen phosphate, the production cost is higher;

[0007] 2. The generated by-products contain a large amount of sodium dihydrogen phosphate, sodium chloride, and ammonium chloride. This part of the mixed salt is listed in the list of haza...

Claims

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