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A kind of preparation method and application of antimicrobial composition containing ε-polylysine

A technology of polylysine and antimicrobial, which is applied in the field of antisepsis and antibacterial, and can solve the problems of low usage and poor inhibitory effect

Active Publication Date: 2021-10-08
北京美科兴业生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a composition containing ε-PL, an antimicrobial agent, a solvent and a synergist. In the composition, ε-PL is compounded with various components, which improves the disadvantage of its own poor inhibitory effect on fungi. The antibacterial effect of ε-PL is enhanced, the antibacterial spectrum is expanded, and it can be applied in various personal care products, daily chemical products and household products. The composition has excellent inhibitory effect on common molds and yeasts , wide antibacterial spectrum, stable effect, low dosage

Method used

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  • A kind of preparation method and application of antimicrobial composition containing ε-polylysine
  • A kind of preparation method and application of antimicrobial composition containing ε-polylysine
  • A kind of preparation method and application of antimicrobial composition containing ε-polylysine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Each component content (weight %) of antimicrobial composition of table 1

[0031]

[0032]

[0033] Preparation method: In a 100mL three-necked bottle with stirring and thermometer, according to the content of each component in Table 1, add ε-PL and the ingredients in the solvent except water, stir and heat to 35-40°C, then add water, and maintain the corresponding temperature , stir and add the rest of the antimicrobial agent components, continue to stir until completely dissolved and then cool down to below 35°C to obtain a stable and transparent antimicrobial composition solution formula.

Embodiment 2

[0035] Investigate the cold resistance of part of the formulation in Example 1, heat resistance, light stability, and compare with the product described in the reference document (publication number CN104958248A, a kind of biological antibacterial composition and its application in cosmetics), the results are shown in figure 1 , figure 2 ,Table 2.

[0036] Formulation stability of table 2 part

[0037]

[0038] figure 1 , figure 2 , Table 2 shows that the color of the composition formula does not change under light and high temperature conditions, and the content of the target active substance remains unchanged, while the color of the comparison product changes greatly under light and high temperature conditions, reflecting the combination of ε-PL in this description good stability of the material.

[0039] Compare Product Formula Combinations:

[0040] ε-PL 0.5%; nisin 0.1%; natamycin 0.4%; glycerol 5%; 1,3-butanediol 3%; caprylyl glycol 1%.

Embodiment 3

[0042] Anti-bacterial (inhibitory) test - minimum inhibitory concentration (MIC value) determination.

[0043] The minimum inhibitory concentration (MIC value) of some antimicrobial compositions and ε-PL in Table 1 was determined by the suspension method, and the results are shown in Table 3.

[0044] The minimum inhibitory concentration (MIC value) of some compositions in table 3

[0045]

[0046]

[0047] Table 3 shows the minimum inhibitory concentration of ε-PL single product and some composition formulations. It can be seen that the inhibitory effect of ε-PL on fungi is much different than that on bacteria, and the composition formulation contains ε-PL 10%-20% On the basis of compounding other varieties of antimicrobial agents, the MIC value converted to the pure product is still comparable to that of the single product. Taking formula 5# as an example, the MIC against Staphylococcus aureus is 500ppm, of which ε-PL The content is 20%, and the MIC value converted into...

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Abstract

The invention discloses a preparation method and application of an antimicrobial composition containing ε-polylysine. It consists of 1-20% of ε-polylysine, 5-35% of other antimicrobial agents, and 60-90% of solvent and synergist. The antimicrobial agent is one of caprylyl hydroxamic acid, levulinic acid, sodium levulinate, p-hydroxyacetophenone, ethyl lauroyl arginate hydrochloride, tropolone, and octenidine one or a mixture of two. Solvents and builders are 1,2-propylene glycol, methyl propylene glycol, 1,3-propylene glycol, 1,3-butanediol, 1,2-hexanediol, 1,2-pentanediol, 1,2 A mixture of one or at least two of ‑caprylyl glycol, 1,2‑decanediol, polyethylene glycol, ethylhexylglycerin, propylene glycol carbonate, and water. The composition is water-soluble, convenient to add and use, and widely used in the fields of cosmetics, wet wipes, facial masks, washing and the like.

Description

[0001] The previous patent application of this application is the application date of 2019.04.29; the application number is 201910355595.5; the invention application patent with the title of "A preparation method and application of an antimicrobial composition containing ε-polylysine". technical field [0002] The invention relates to an antimicrobial composition containing ε-polylysine, which is mainly used for antisepsis and antibacterial of personal care products such as cosmetics, wet wipes and washing products and household products. Background technique [0003] ε-polylysine (hereinafter referred to as ε-PL) is derived from the fermentation product of Streptomyces albicans and is a natural microbial preservative. It was approved by the US FDA as a safe food preservative in October 2003 and is widely used in food preservation . ε-PL has a broad antibacterial spectrum, and has inhibitory effects on Gram-positive and negative bacteria, molds, and yeasts, but the inhibitor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/40A01N37/46A01N37/42A01N37/28A01N47/44A01N35/06A01N35/04A01P1/00A01P3/00A61K8/88A61K8/49A61K8/44A61K8/42A61K8/35A61K8/34A61Q19/00
CPCA01N35/04A01N35/06A01N37/28A01N37/42A01N37/46A01N43/40A01N47/44A61K8/345A61K8/35A61K8/42A61K8/44A61K8/4926A61K8/88A61K2800/524A61Q19/00
Inventor 张慧明冯士清吕萌蒙雪艳于跃
Owner 北京美科兴业生物科技有限公司
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