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Millimetre micro-capsules and preparation method thereof

A microcapsule, millimeter-scale technology, applied in the field of microcapsule preparation, can solve problems such as difficult to achieve water volatilization rate, unsuitable for millimeter-scale capsules, narrow range of wall material selection, etc.

Active Publication Date: 2019-10-08
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are microfluidic methods to prepare water-encapsulated microcapsules, generally only capsules with a particle size of tens to hundreds of microns can be prepared, which is not suitable for the preparation of millimeter-scale capsules. The roundness and forming rate of millimeter-scale capsules are difficult to maintain. A current problem
In addition, due to the relatively long preparation cycle of this type of method, the continuous stability of the water-in-oil structure is required to be high, the selection range of wall materials is narrow, and the technical efficiency is low.
Moreover, it is difficult to achieve high sealing performance and continuous high-efficiency preparation of water-containing microcapsules in the prior art, and it is difficult to achieve a moisture volatilization rate of less than 10% when stored at room temperature for 6 months

Method used

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  • Millimetre micro-capsules and preparation method thereof
  • Millimetre micro-capsules and preparation method thereof
  • Millimetre micro-capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Adopt the method of Example 1 in CN 106540638A to prepare polymer water-in-capsules:

[0095] The inner phase (A) chooses pure water, the middle phase (B) chooses acrylic resin and diluent (Evergreen resin 6215-100 and tripropylene glycol diacrylate (TPGDA)) 1:4 mixed (containing 3% photoinitiator, 2 -Hydroxy-2-methyl-1-phenyl-1-propanone, 1173), the external phase (C) chooses water (containing 1% PVA). The distance between the pipe (1) and the pipe (3) is 3 mm, and the width of the curing channel is 1.5 mm. The internal phase (A), intermediate phase (B), and external phase (C) were pumped into pipelines (1), (2), ( In 3), a water-in-oil-in-water emulsion is generated through the action of shear force and gravity. After the emulsion flows to the curing channel (4), the mesophase is cured under the radiation of ultraviolet light to form a polymer-coated emulsion. water capsules.

[0096] Its preparation adopts micro / millifluidic chip, and its structure includes: sampl...

Embodiment 2

[0111] Embodiment 2: Effect of different oil phase viscosities on the performance of millimeter-scale microcapsules

[0112] In this example, the influence of different oil phase viscosities on the performance of millimeter-sized microcapsules was tested.

[0113] The specific preparation process is as follows:

[0114] 1. Preparation of the aqueous phase system: the inner aqueous phase is an aqueous solution of carboxymethyl cellulose with a concentration of 1%, and the outer aqueous phase is used as a mobile phase.

[0115]2. Preparation of light-curing materials (mass ratio): mix bisphenol A epoxy acrylic resin with dipropylene glycol diacrylate, 27 parts of tetrahydrofuran acrylate, 3 parts of 2-hydroxy-methylphenylpropane-1- Ketones are mixed evenly, wherein different parts of dipropylene glycol diacrylate are added to control the configuration of oil phases with different viscosities;

[0116] 3. Construction of the microfluidic device: connect the thicker side of the ...

Embodiment 3

[0122] Embodiment 3: the impact of different flow rate ranges on the performance of millimeter-scale microcapsules

[0123] In this example, the effects of different flow rate ranges on the performance of millimeter-scale microcapsules were tested.

[0124] The specific preparation process is as follows:

[0125] 1. Preparation of the aqueous phase system: the inner aqueous phase is an aqueous solution of carboxymethyl cellulose with a concentration of 1%, and the outer aqueous phase is used as a mobile phase.

[0126] 2. Preparation of light-curing material (mass ratio): configure an oil phase with a viscosity of 200, specifically 40 parts of bisphenol A epoxy acrylic resin: dipropylene glycol diacrylate: tetrahydrofuran acrylate: 2-hydroxy- Mix the methyl phenylpropan-1-one evenly according to the ratio of 50:20:27:3.

[0127] 3. Construction of the microfluidic device: connect the thicker side of the Y-shaped connector to a silicone tube with an inner diameter of 1.2mm wi...

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Abstract

The invention discloses millimetre micro-capsules and a preparation method thereof, and belongs to the technical field of micro-capsule preparation. Continuous production is realized by combining a microfluidic technology and a UV photocuring technology, the particle size and the wall thickness of micro-capsules are realized through the design of a microfluidic pipeline, and the mechanical properties of the micro-capsules are realized through the blending of a resin system or the regulation and control of the wall thickness. The micro-capsules have a scale of 1-8mm, can be rapidly and continuously prepared, can wrap any aqueous solution, can realize controllable preparation of aqueous phase micro-capsules, and the moisture volatilization amount of the micro-capsules is not more than 15% after being stored at room temperature (25 degrees) for half a year.

Description

technical field [0001] The invention relates to a millimeter-scale microcapsule and a preparation method thereof, belonging to the technical field of microcapsule preparation. Background technique [0002] The microcapsule is composed of a shell material and an inner cavity. The inner hollow cavity can be used to place active substances, and the wall material can isolate the surrounding environment, thereby protecting the active substances. Microcapsules are used in a wide range of fields, such as medicine, food, cosmetics and other fields that are closely related to life. [0003] Water-soluble flavors and fragrances, water-soluble drugs, water-based inks, water-soluble nutrients, etc., have broad application prospects in food, tobacco, paper, cosmetics and other fields. For example, moisture retention of cigarettes is currently a topic of concern in the industry. The moisture content of cigarette smoke has an important impact on the sensory quality of cigarettes. Increasi...

Claims

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Application Information

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IPC IPC(8): B01J13/02B01J13/14C11B9/00A61K9/50A61K47/32A61K47/34C08F283/10
CPCA61K9/5026A61K9/5031B01J13/02B01J13/14C11B9/00C11B9/0015
Inventor 刘仁孙冠卿李治全
Owner JIANGNAN UNIV
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