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Silk fibroin conductive hydrogel and preparation method thereof

A technology of conductive hydrogel and silk fibroin, which is applied in the field of silk fibroin conductive hydrogel and its preparation, can solve the problems of weak conductive effect and low tensile strength, and achieves improved tensile properties and elastic modulus. , the effect of high conductivity

Active Publication Date: 2019-10-08
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to provide a silk fibroin conductive hydrogel and a preparation method thereof, so as to overcome the defects of weak conductive effect and low tensile strength in existing conductive hydrogels

Method used

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  • Silk fibroin conductive hydrogel and preparation method thereof
  • Silk fibroin conductive hydrogel and preparation method thereof

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preparation example Construction

[0035] The present invention also provides a preparation method of silk fibroin conductive hydrogel, the method comprising:

[0036] (1) Preparation of carboxylated silk fibroin powder: degumming, dissolving, and dialysis of silk to obtain a silk fibroin solution; chemically modifying the silk fibroin solution with borax, diazonium salt, and chloroacetic acid to obtain a concentration of 0.1% -50% carboxylated silk fibroin solution; dialyze the carboxylated silk fibroin solution and freeze-dry to obtain carboxylated silk fibroin powder. The concentration of the carboxylated silk fibroin solution is 0.1%-50%. Within this concentration range, the silk fibroin can graft the host cyclodextrin and the guest adamantane to the greatest extent.

[0037] (2) Preparation of polyphenol-modified graphene nanoflakes: disperse graphene powder in a solution of polyphenol compounds, and obtain polyphenol-modified graphite with a concentration of 1-10 mg / ml after ultrasonication, centrifugatio...

Embodiment 1

[0045] (1) Preparation of carboxylated silk fibroin powder: silk was treated with Na 2 CO 3 The solution was degummed, LiBr solution was dissolved, and a silk fibroin solution with a concentration of 6% was prepared by deionized water dialysis; 10 mL silk fibroin solution was mixed with 8 mL, 1 M chloroacetic acid, reacted at room temperature for 50 min, and then Then add 1 mL NaH 2 PO 4 solution, reacted in an ice bath for 30 min to obtain a carboxylated silk fibroin solution; after dialysis and freeze-drying, a carboxylated silk fibroin powder was obtained.

[0046] (2) Preparation of polyphenol-modified graphene nanoflakes: Disperse 45 mg of graphene powder in 10 mL of dopamine solution, sonicate for 30 min, and centrifuge the reaction product at 1500 r / min for 30 min to remove untreated The exfoliated graphene; then the supernatant was centrifuged at 6000 r / min for 30 min to remove excess dopamine, and the precipitate was resuspended in deionized water to obtain polyphe...

Embodiment 2

[0054] (1) Preparation of carboxylated silk fibroin powder: silk was treated with Na 2 CO 3The solution was degummed, LiBr solution was dissolved, and a silk fibroin solution with a concentration of 6% was prepared by deionized water dialysis; 10 mL silk fibroin solution was mixed with 8 mL, 1 M chloroacetic acid, reacted at room temperature for 50 min, and then Then add 1 mL NaH 2 PO 4 solution, reacted in an ice bath for 30 min to obtain a carboxylated silk fibroin solution; after dialysis and freeze-drying, a carboxylated silk fibroin powder was obtained.

[0055] (2) Preparation of polyphenol-modified graphene nanoflakes: Disperse 45 mg of graphene powder in 10 mL of dopamine solution, sonicate for 30 min, and centrifuge the reaction product at 1500 r / min for 30 min to remove untreated The exfoliated graphene; then the supernatant was centrifuged at 6000 r / min for 30 min to remove excess dopamine, and the precipitate was resuspended in deionized water to obtain polyphen...

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Abstract

The invention discloses a silk fibroin conductive hydrogel and a preparation method thereof. The silk fibroin conductive hydrogel is a silk fibroin conductive hydrogel constructed by using a silk fibroin molecule as a matrix, and introducing a host, a guest, a horseradish peroxidase and a polyphenol-modified graphene nanosheet in an amino acid side chain of the silk fibroin molecule, and has bothsuper-strong stretching and self-attaching functions. The prepared hydrogel has a conductivity of 10 s / m, and has good mechanical properties, the tensile deformation capacity can be up to 500%, and the hydrogel can be closely attached to the surface of human tissues or other articles, and can be repeatedly attached. More importantly, the hydrogel material can still retain excellent electrical conductivity, tensile resistance and self-attaching properties under high frequency use. The preparation of the silk fibroin conductive hydrogel provides a better material platform for production and application of a new generation of flexible bio-electronic products.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a silk fibroin conductive hydrogel and a preparation method thereof. Background technique [0002] In recent years, with the rise of wearable electronics and Internet of Things technologies, the application of flexible devices in medical diagnosis, motion monitoring, intelligent robots and other fields has received more and more attention. Conductive hydrogel is an ideal interface material for perfect compatibility between the human body and bioelectronic devices, and can perfectly fit the skin to detect corresponding physiological stimuli. In order to achieve long-term stable and efficient human-computer interface interaction, conductive hydrogels need to possess good biocompatibility, toughness, excellent stability, and high electrical conductivity. However, the existing conductive hydrogels have low elongation and are prone to permanent damage under high-frequency use, a...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08L5/16C08K9/04C08K7/00C08K3/04C08H1/00C08B37/16
CPCC08J3/075C08H1/00C08B37/0015C08J2389/00C08J2405/16C08K9/04C08K7/00C08K3/042C08K2201/011
Inventor 黄晓卫
Owner QINGDAO UNIV
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