Composition for preventing hair loss and promoting hair growth, comprising fermented marine animal products

A technology for aquatic animals and fermented products, applied in application, food science, hair care, etc., to achieve the effect of no toxicity and side effects, safe and long-term use

Pending Publication Date: 2019-10-11
IND ACADEMIC COOPERATION FOUND JEJU NAT UNIVERSTIY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, it has not been reported that the fermentation product of aquatic animals or fish...

Method used

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  • Composition for preventing hair loss and promoting hair growth, comprising fermented marine animal products
  • Composition for preventing hair loss and promoting hair growth, comprising fermented marine animal products
  • Composition for preventing hair loss and promoting hair growth, comprising fermented marine animal products

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Embodiment 1: the preparation of fermented fish oil

[0069] The fermented fish oil used as the experimental material was supplied by Qinglong Aquatic Products Co., Ltd. Specifically, the by-products produced when processing five types of aquatic products including mackerel, horsehead fish, puffer fish, and flounder at Qinglong Fisheries Co., Ltd.'s fishery processing plant, which is frozen and stored in units of 10 kg for each type, were used. The above-mentioned raw materials were put into a stainless steel fermentation vessel with a weight of 50 Kg, and 10 Kg of commercially available sucrose and fermenting microorganisms were added as a culture substrate. As yeast and lactic acid bacteria as fermenting microorganisms, inoculate 2L of pre-cultured Lactobacillus plantarum (Lactobacillus plantarum) (1.0×10 8 cells / cfu) and Saccharomyces cerevisiae (3.0×10 8 cells / cfu), cultured at 30°C for 15 days, and then fermented for 50-60 days. After the cultivation and ferment...

Embodiment 2

[0072] Example 2: Confirmation of the proliferation-promoting effect of fermented fish oil on dermal papilla cells (DPCs)

[0073] Using DMEM (Hyclone Inc, USA) medium containing 100units / ml penicillin-100μg / ml streptomycin (Gibco Inc, NY, USA) and 10% heat-inactivated fetal bovine serum (FBS; Gibco Inc, NY, USA), in 37°C temperature in 5% CO 2 Immortalized dermal papilla cells (Rat vibrissa immortalized dermal papilla cells: Filsell W, et al., 1994) isolated from whiskers of white mice were cultured in a thermostat, and subcultured every three days. Proliferation of dermal papilla cells was measured by MTT assay. Dermal papilla cells (dermal papilla cell) 5.0×10 4 The cells / ml were cultured in DMEM medium containing 1% FBS, put into a 24-well plate (well plate), and after culturing for 24 hours, processed the fermented fish oil at concentrations of 12.5 μg / ml, 25 μg / ml and 50 μg / ml. As a positive control, minoxidil (Sigma, MO, USA) was treated at a concentration of 10 μM. ...

Embodiment 3

[0075] Example 3: Measurement of hair growth efficacy of fermented fish oil

[0076] Six-week-old female C57BL / 6 mice were purchased from Orient Bio Co., Ltd., and used for experiments after acclimatization in the animal breeding room environment for one week. The temperature in the animal breeding room was 23±3°C, and the day and night lasted for 12 hours respectively. Experimental animals were raised in isolated mouse cages and fed with experimental feed freely. The experimental group consists of 5 groups, which are the control group and the positive control group MINOXYL TM (5% Minoxidil) (modern drug) and fermented fish oil (10 μg / ml, 50 μg / ml, 100 μg / ml; solvent is 50% ethanol) coating group. In order to observe the hair-raising effect, a 7-week-old telogen shaved back skin was used. The hair on the back of the mouse was completely shaved using a clipper for animals, and after 2 days, the mouse that was visually recognized as having no damage on the skin was selected f...

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Abstract

The present invention relates to a pharmaceutical composition for preventing hair loss or promoting hair growth, comprising fermented fish oil. The composition comprising the fermented fish oil is recognized to be effective in suppressing and preventing hair loss and promoting hair growth, and thus can be variously used in fields such as pharmacy, cosmetics, and beauty.

Description

technical field [0001] The present invention relates to a composition containing fermented products of aquatic animals for preventing hair loss and promoting hair growth. Background technique [0002] There are about 100,000 to 150,000 human hairs, which are formed in "hair follicles". In the hair follicle, there is a dermal papilla, where small blood vessels are distributed to supply nutrients needed for hair growth, and on the side above the dermal papilla, there are sebaceous glands that supply the hair with oil for giving luster. Hair follicles are composed of several different epithelial cells and dermal papilla cells (DPCs). Dermal papilla cells are mesenchymally-derived fibroblasts located at the base of the hair follicle that play an important role in hair growth. In particular, it has been reported that minoxidil has proliferative and anti-apoptotic effects on dermal papilla cells. Similarly, several reports have shown that proliferation of dermal papilla cells l...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61K8/98A23L33/10A61Q7/00
CPCA23L33/10A61K8/98A61K35/60A61Q7/00A61K8/987A23V2250/2042A23V2002/00A23V2200/318A61K2800/85A61K2236/19
Inventor 姜希炅姜正一尹壎硕金成珉朴贞彦安容奭
Owner IND ACADEMIC COOPERATION FOUND JEJU NAT UNIVERSTIY
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