Degradable drug-loaded film material with step-by-step slow release function and preparation method and application of degradable drug-loaded film material
A drug-loaded film and functional technology, which is applied in the field of degradable drug-loaded film materials and its preparation, can solve the problems of limited sustained release requirements, long-lasting effect, and insufficient coating rate.
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Embodiment 1
[0040] Step 1: Weigh 0.5g of avermectin and dissolve it in 10mL of chloroform, and ultrasonically treat it at 20°C for 20 minutes to obtain a core material solution for use;
[0041]Step 2: Weigh 1g of gelatin at 50°C and stir at a speed of 200r / min, dissolve it in 20mL distilled water until it swells completely to obtain the first wall material solution; weigh 1g of gum arabic at 50°C and stir at 200r / min Stir at a high speed, dissolve in 20mL distilled water until fully swollen to obtain the second wall material solution;
[0042] Step 3: Emulsify the core material solution, the first wall material solution and 2mL sorbitan fatty acid ester at 30°C at a speed of 600r / min for 20min, then add dropwise to the second wall material solution, at 300r / min Stir at a high speed for 1.5h to obtain system A;
[0043] Step 4: Use hydrochloric acid to adjust the pH of system A to 4.0, stir at a speed of 500r / min for 15min, transfer to a cold water bath at 8°C for re-coagulation for 1h; ...
Embodiment 2
[0047] Step 1: Weigh 0.5g of avermectin and dissolve it in 5mL of chloroform, and ultrasonically treat it at 20°C for 20 minutes to obtain a core material solution for use;
[0048] Step 2: Weigh 1g of gelatin at 50°C, stir at a speed of 400r / min, dissolve in 50mL of distilled water until completely swollen to obtain the first wall material solution; weigh 1g of gum arabic at 50°C, stir at a speed of 400r / min Stir at a high speed, dissolve in 50mL distilled water until fully swollen to obtain the second wall material solution;
[0049] Step 3: Emulsify the core material solution, the first wall material solution and 2mL of sorbitan fatty acid ester at 30°C at a speed of 600r / min for 5min, then add dropwise to the second wall material solution, at 300r / min Stir at a high speed for 2 hours to obtain System A;
[0050] Step 4: Use hydrochloric acid to adjust the pH of system A to 5.0, stir at a speed of 500r / min for 15min, transfer to a cold water bath at 8°C for re-coagulation ...
Embodiment 3
[0054] Step 1: Weigh 0.5g of abamectin and dissolve it in 20mL of chloroform, and ultrasonically treat it at 20°C for 20min to obtain a core material solution for use;
[0055] Step 2: Weigh 1g of gelatin at 50°C, stir at a speed of 300r / min, dissolve in 60mL of distilled water until completely swollen to obtain the first wall material solution; weigh 1g of gum arabic at 50°C, stir at a speed of 300r / min Stir at a high speed, dissolve in 60mL distilled water until completely swollen to obtain the second wall material solution;
[0056] Step 3: Emulsify the core material solution, the first wall material solution and 2mL of sorbitan fatty acid ester at 30°C at a speed of 600r / min for 30min, then add dropwise to the second wall material solution, at 300r / min Stir at a high speed for 1h to obtain system A;
[0057] Step 4: Use tartaric acid to adjust the pH of system A to 4.5, stir at a speed of 500r / min for 15min, transfer to a cold water bath at 8°C for re-coagulation for 1h; ...
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