Degradable drug-loaded film material with step-by-step slow release function and preparation method and application of degradable drug-loaded film material

A drug-loaded film and functional technology, which is applied in the field of degradable drug-loaded film materials and its preparation, can solve the problems of limited sustained release requirements, long-lasting effect, and insufficient coating rate.

Active Publication Date: 2019-10-25
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the shortcomings of microcapsules, which are easy to absorb water and swell, and have low strength and modulus after swelling, the requirements for sustained release are limited.
However, the preparation process of traditional coating materials is relatively complicated, the coating rate is not high enough, and the duration of efficacy needs to be improved

Method used

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  • Degradable drug-loaded film material with step-by-step slow release function and preparation method and application of degradable drug-loaded film material
  • Degradable drug-loaded film material with step-by-step slow release function and preparation method and application of degradable drug-loaded film material
  • Degradable drug-loaded film material with step-by-step slow release function and preparation method and application of degradable drug-loaded film material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Step 1: Weigh 0.5g of avermectin and dissolve it in 10mL of chloroform, and ultrasonically treat it at 20°C for 20 minutes to obtain a core material solution for use;

[0041]Step 2: Weigh 1g of gelatin at 50°C and stir at a speed of 200r / min, dissolve it in 20mL distilled water until it swells completely to obtain the first wall material solution; weigh 1g of gum arabic at 50°C and stir at 200r / min Stir at a high speed, dissolve in 20mL distilled water until fully swollen to obtain the second wall material solution;

[0042] Step 3: Emulsify the core material solution, the first wall material solution and 2mL sorbitan fatty acid ester at 30°C at a speed of 600r / min for 20min, then add dropwise to the second wall material solution, at 300r / min Stir at a high speed for 1.5h to obtain system A;

[0043] Step 4: Use hydrochloric acid to adjust the pH of system A to 4.0, stir at a speed of 500r / min for 15min, transfer to a cold water bath at 8°C for re-coagulation for 1h; ...

Embodiment 2

[0047] Step 1: Weigh 0.5g of avermectin and dissolve it in 5mL of chloroform, and ultrasonically treat it at 20°C for 20 minutes to obtain a core material solution for use;

[0048] Step 2: Weigh 1g of gelatin at 50°C, stir at a speed of 400r / min, dissolve in 50mL of distilled water until completely swollen to obtain the first wall material solution; weigh 1g of gum arabic at 50°C, stir at a speed of 400r / min Stir at a high speed, dissolve in 50mL distilled water until fully swollen to obtain the second wall material solution;

[0049] Step 3: Emulsify the core material solution, the first wall material solution and 2mL of sorbitan fatty acid ester at 30°C at a speed of 600r / min for 5min, then add dropwise to the second wall material solution, at 300r / min Stir at a high speed for 2 hours to obtain System A;

[0050] Step 4: Use hydrochloric acid to adjust the pH of system A to 5.0, stir at a speed of 500r / min for 15min, transfer to a cold water bath at 8°C for re-coagulation ...

Embodiment 3

[0054] Step 1: Weigh 0.5g of abamectin and dissolve it in 20mL of chloroform, and ultrasonically treat it at 20°C for 20min to obtain a core material solution for use;

[0055] Step 2: Weigh 1g of gelatin at 50°C, stir at a speed of 300r / min, dissolve in 60mL of distilled water until completely swollen to obtain the first wall material solution; weigh 1g of gum arabic at 50°C, stir at a speed of 300r / min Stir at a high speed, dissolve in 60mL distilled water until completely swollen to obtain the second wall material solution;

[0056] Step 3: Emulsify the core material solution, the first wall material solution and 2mL of sorbitan fatty acid ester at 30°C at a speed of 600r / min for 30min, then add dropwise to the second wall material solution, at 300r / min Stir at a high speed for 1h to obtain system A;

[0057] Step 4: Use tartaric acid to adjust the pH of system A to 4.5, stir at a speed of 500r / min for 15min, transfer to a cold water bath at 8°C for re-coagulation for 1h; ...

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Abstract

The invention discloses a degradable drug-loaded film material with a step-by-step slow release function and a preparation method and application of the degradable drug-loaded film material, and belongs to the technical field of material preparation. Natural polymers with opposite charges and a crude drug are re-agglomerated to obtain a drug-loaded microcapsule, the surface of the microcapsule isprovided with micropores with the uniform size, and thus channels are provided for initial release of the drug; and then the drug-loaded microcapsule is dispersed into biodegradable aliphatic polyester, and through the effect of interface chemical bonds, the microcapsule is fixed into polyester molecules to form a biodegradable material. When being released, the drug can be released into an aliphatic polyester film from the micropores of the microcapsule through the diffusion effect so as to be subjected to first-layer release firstly, the drug released in the film can be subjected to second-layer slow release along with degradation of a polyester film material, on the one hand, the efficient slow-release effect on the drug is achieved, on the other hand, the degradation speed of the aliphatic polyester is increased, environmental pollution is reduced, according to the method, a process is simple, raw materials are easy to obtain, and batch production can be achieved.

Description

technical field [0001] The invention belongs to the technical field of material preparation, and in particular relates to a degradable drug-loaded film material with a gradual slow-release function, a preparation method and application thereof. Background technique [0002] As a country with developed agricultural level, the production and consumption of plastic film and pesticides in my country are huge. With the popularization and application of traditional polyethylene plastic film covering cultivation technology, residual plastic film not only pollutes the soil, hinders farming, but also causes soil structure damage. . Pesticide control is one of the effective means to control pests and diseases, but the loss rate during the use of pesticides can reach 50% to 60%, which reduces the efficiency of pesticides in killing pests and diseases, and traditional pesticides cannot avoid sun exposure, wind blowing, rain, etc. The decomposition and loss of medicines caused by objecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/28A01N25/10A01N43/88A01N57/16A01N47/40A01N43/90A01N57/14A01P7/04A01P7/02A01P3/00A01P1/00A01P13/00
CPCA01N25/28A01N25/10A01N43/88A01N57/16A01N47/40A01N43/90A01N57/14
Inventor 张敏李月茹李成涛王蕾
Owner SHAANXI UNIV OF SCI & TECH
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