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A kind of Polygonatum preparation and preparation method

A Polygonatum chinensis and preparation technology, which is applied in the directions of pharmaceutical formulations, non-active ingredients medical preparations, and medical preparations containing active ingredients, etc. Easy absorption and utilization, strong pharmacological action, clear efficacy

Active Publication Date: 2021-12-28
ZHEJIANG WANSHOUKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And many health care products or medicines have a long time of metabolism and absorption in the human body because of sealwort powder or crude products, and the utilization rate is not high, and the effect of sealwort is also limited in the disease field where it plays a role

Method used

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  • A kind of Polygonatum preparation and preparation method
  • A kind of Polygonatum preparation and preparation method
  • A kind of Polygonatum preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The extraction method of flavonoids in the sealwort of embodiment 1

[0052] This embodiment discloses the extraction method of flavonoids in Polygonatum, the extraction preparation method is as follows:

[0053] a, by the weight-to-volume ratio of 1: 5m / v, carry out continuous countercurrent extraction at 60 ℃ with the pulverized raw material of Polygonatum leaf and stem and the water of 10% v / v and methanol mixed solvent, water and methanol mixed solvent are to every kilogram of Rhizoma Polygonatum The flow rate of the raw material is 2.5L / h;

[0054] b. After concentrating the extraction solution, the flavonoid crude product is dispersed with water and subjected to ultrafiltration. The ultrafiltration conditions are: the ultrafiltration membrane specification is 1K, the membrane penetration pressure is 20PSI, and the permeation flow rate is 15LMH to obtain the filtrate;

[0055] c. Adsorption and elution of the filtrate after ultrafiltration with polar resin, the ad...

Embodiment 2

[0057] The extraction method of flavonoids in the sealwort of embodiment 2

[0058] This embodiment discloses the extraction method of flavonoids in Polygonatum, the extraction preparation method is as follows:

[0059] a, according to the weight-to-volume ratio of 2: 6.5m / v, the pulverized raw material of Polygonatum leaves and stems and the water and methanol mixed solvent of 15% v / v are carried out continuous countercurrent extraction at 65 ℃, and water and methanol mixed solvent are to every kilogram The flow velocity of sealwort raw material is 2.0L / h;

[0060] b. After concentrating the extraction solution, the flavonoid crude product is dispersed in water and subjected to ultrafiltration. The ultrafiltration conditions are: the ultrafiltration membrane specification is 1K, the membrane penetration pressure is 22PSI, and the permeation flow rate is 20LMH to obtain the filtrate;

[0061] c. Use polar resin to adsorb and elute the filtrate after ultrafiltration. The adsor...

Embodiment 3

[0063] The extraction method of flavonoids in the sealwort of embodiment 3

[0064] This embodiment discloses the extraction method of flavonoids in Polygonatum, the extraction preparation method is as follows:

[0065] a, according to the weight volume ratio of 5~2.5m / v, carry out continuous countercurrent extraction at 80 ℃ with the pulverized raw material of Polygonatum leaves and stems and the mixed solvent of water and methanol of 7% v / v, the mixed solvent of water and methanol is to every kilogram The flow velocity of sealwort raw material is 2.5L / h;

[0066] b. After concentrating the extraction solution, the flavonoid crude product is dispersed with water and subjected to ultrafiltration. The ultrafiltration conditions are: the ultrafiltration membrane specification is 1K, the membrane permeability is 30PSI, and the permeation flow rate is 35LMH to obtain the filtrate;

[0067] c. Adsorption and elution of the filtrate after ultrafiltration with polar resin, the adsor...

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Abstract

The invention discloses a Polygonatum preparation and a preparation method thereof. The Polygonatum preparation comprises flavonoids, nano selenium, a reducing agent and additives. The prepared Polygonatum preparation can effectively alleviate various diseases of rheumatoid, and achieve the cure of rheumatoid arthritis, so that the application value of Polygonatum can be better developed, and the preparation of Polygonatum preparation is convenient to take, which is beneficial to the absorption and utilization of the human body, and has a high utilization rate. The effect is good. Compared with the sealwort health product prepared from sealwort powder and crude sealwort, the effective utilization rate is improved.

Description

technical field [0001] The invention relates to the technical field of medical and health preparations, in particular to a Polygonatum preparation and a preparation method. Background technique [0002] Polygonatum is a perennial herb of the genus Polygonatum mill in the family Liliaceae, and its rhizome is used for medicine. Aliases include chicken head ginseng, sac silk sealwort, polygonatum polygonatum, ginger-shaped sealwort, chicken head sealwort, wild fairy ginger, mountain ginger, deer bamboo, fairy surplus grain, rescue grass, etc. It is widely distributed in the world, and there are more than 60 species, mainly in the northern subtropical and northern temperate regions; there are about 31 species in my country, which are widely distributed in areas other than the southern tropics. Polygonatum cyrtonemaHua, Polygonatum kingianum Coll.et Hemsl., and Polygonatum sibiricumRed. are recorded in Chinese Pharmacopoeia as native medicines. [0003] Polygonatum has a dry ta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K36/8969A61K47/32A61P37/02
CPCA61K36/8969A61K9/5138A61P37/02A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55
Inventor 陈喜良金美艳
Owner ZHEJIANG WANSHOUKANG PHARMA CO LTD
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