Diabetic foot repair nanofilm and preparation method thereof

A technology of diabetic foot and nano-membrane, which is applied in medical formula, medical science, absorbent pads, etc., can solve the problems of subsequent bacterial invasion and infection, prevent wound healing, and large modulus, so as to achieve comfortable and convenient implementation, promote epithelial reconstruction, and biological good compatibility

Inactive Publication Date: 2019-11-05
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Medical adhesive tape has low adhesion strength, poor adaptability to complex wounds, and it is difficult to completely cover the wound, resulting in subsequent bacterial invasion and infection
Surgical sutures need to be operated by professional doctors, causing pain to patients when using them, difficult to repair microtrauma, and easy to cause infection
Commercial bioglues mainly include fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but its adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity, and will prevent wound healing, high modulus is brittle, difficult to adapt to the tissue
[0005] Diabetic foot wounds are complex in shape, and it is difficult to apply ordinary wet dressings to the ulcerated wounds between the toes. Moreover, due to the lack of adhesion during use, the dressing is prone to partial or even complete detachment, and the exposed part will cause blood or tissue fluid to leak out. and increased risk of bacterial infection
The dressings currently used clinically are basically block materials, which are difficult to fully meet the complex wound adhesion requirements of diabetic feet

Method used

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  • Diabetic foot repair nanofilm and preparation method thereof
  • Diabetic foot repair nanofilm and preparation method thereof
  • Diabetic foot repair nanofilm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The diabetic foot repair nano-membrane provided by this implementation is composed of the following components by mass percentage:

[0024]

[0025] Wherein, the polymer matrix material is composed of one or more of polysaccharides, cellulose, collagen, and silk fibroin; the epithelial-promoting factor is one of the polypeptides derived from integrin-binding survival-promoting peptides. or several components; the pro-angiogenic factor is composed of one or several of the polypeptides derived from pro-angiogenic proteins; the protective layer is composed of one of polyvinyl alcohol, cellulose, and water-soluble polysaccharides or several components.

[0026] The following is the preferred scheme for the preparation of the above-mentioned diabetic foot repair nano-membrane of the present embodiment, the specific circumstances are as follows:

[0027] Dissolve silk fibroin in a hexafluoroisopropanol solution, add the resulting silk fibroin solution dropwise onto a sing...

Embodiment 2

[0029] The difference from Example 1 is that in this example, the silk fibroin is configured into an aqueous solution, and the obtained silk fibroin solution is dripped onto a single crystal silicon wafer, and the parameters are: the rotation speed is 6000 rpm, and the rotation time is 30s. Coated to obtain a polymer matrix nanofilm with a total mass of 0.8%; the dried polymer matrix nanofilm was soaked in methanol solution for 10 minutes and then air-dried; the dried polymer matrix nanofilm was soaked in 1-(3-bis Methylaminopropyl)-3-ethylcarbodiimide hydrochloride / N-hydroxysuccinimide solution was taken out after 10 min; polymer matrix nano-film was soaked in 0.075% promoting epithelial formation, promoting angiogenesis factor Take it out after 2h in the aqueous solution to realize the loading of the factor; add the polyvinyl alcohol aqueous solution that accounts for 99.05% of the total mass dropwise on the nano-membrane of the above loading factor, and the parameters are: t...

Embodiment 3

[0031] The difference from Example 1 is that in this example, silk fibroin is dissolved in formic acid solution, and the resulting silk fibroin solution is dripped onto a single crystal silicon wafer, and the parameters are: the rotation speed is 6000rpm, and the time is 30s. Carry out spin-coating, make the macromolecule matrix nanofilm that total mass is 0.8%; Air-dry after the macromolecule matrix nanofilm soaked in the methanol solution after drying; Soak the dry macromolecule matrix nanofilm in 1-(3 -Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / N-hydroxysuccinimide solution was taken out after 10 minutes; the polymer matrix nano-film was soaked in 0.075% promoting epithelial formation, promoting blood vessel After 2 hours in the aqueous solution of the formation factor, take it out to realize the loading of the factor; drip an aqueous solution of polyvinyl alcohol that accounts for 99.05% of the total mass onto the nano-membrane of the above-mentioned loading fac...

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PUM

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Abstract

The invention discloses a diabetic foot repair nanofilm and a preparation method thereof. The diabetic foot repair nanofilm is composed of a polymer matrix material, an epithelization promoting factor, a vascularization promoting factor and a protective layer, wherein a natural polymer is used as a matrix material, and the nanofilm with the good mechanical performance is obtained by a spin-coatingmethod; and the epithelization promoting factor and the vascularization promoting factor are loaded onto the nanofilm, and a water-soluble polymer is used as the protective layer to protect the factors. According to the diabetic foot repair nanofilm, the biosecurity is good, use is convenient and comfortable, the wound surface with the complex morphology can be handled, the skin adhesion effect is good, and healing of the wound surfaces of diabetic feet can be promoted.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a diabetic foot repair nano-membrane and a preparation method thereof. Background technique [0002] Huge market, continuous demand, and research and development of soft tissue repair materials have always been hot spots in the field of biomedical materials. [0003] Diabetic foot is one of the serious complications of diabetes, with an incidence rate of 15-20%. The slow treatment of diabetic foot and the high disability rate have brought heavy mental burden and huge economic pressure to individuals, families and society, and become a huge obstacle affecting the promotion of medical care and the construction of a harmonious society in our country. [0004] Medical adhesive tape has low adhesion strength, poor adaptability to complex wounds, and it is difficult to completely cover the wound, resulting in subsequent bacterial invasion and infection. Surgical suturing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22A61L15/42A61L15/44
CPCA61L15/225A61L15/42A61L15/44A61L2300/412A61L2400/12C08L5/00C08L1/02C08L89/00C08L29/04
Inventor 施雪涛杨汇尚宣承楷
Owner SOUTH CHINA UNIV OF TECH
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