Synthetic method for 2-chlorobenzonitrile

A technology of o-chlorobenzonitrile and synthesis method, which is applied in chemical instruments and methods, preparation of organic compounds, purification/separation of carboxylic acid nitrile, etc., can solve the problem of high price of o-chlorobenzaldoxime, influence on yield and product quality, The effect is not very ideal and other problems, to achieve the effect of easy environmental protection treatment, avoiding complicated equipment, and strong market competitiveness
CN110423207AActive Publication Date: 2019-11-08三门峡环宇生化科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
三门峡环宇生化科技有限公司
Publication Date
2019-11-08

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Abstract

A synthetic method for 2-chlorobenzonitrile is disclosed and includes the following steps: performing a reaction on o-chlorobenzoic acid and ammonia to generate ammonium o-chlorobenzoate, high temperature dehydration is performed to produce 2-chlorobenzamide, and the high temperature dehydration is performed again to generate the 2-chlorobenzonitrile. In a production process, especially ultrasonicor microwave catalyzed high temperature dehydration is utilized to produce the 2-chlorobenzonitrile, the yield is up to 93%, and the purity of products can reach 97%. And the method has the characteristics of short process route, high reaction yield, good product purity, safe and clean whole reaction process, and easy environmentally friendly treatment. Production of waste water of the 2-chlorobenzonitrile can be effectively reduced, clean production of the 2-chlorobenzonitrile is achieved, unreacted raw material o-chlorobenzoic acid and intermediates can be recovered and then recycled and utilized, and the production cost can be significantly reduced. Moreover, the method can avoid the defects that traditional process equipment is complex, is high in operation requirements and is low inproduct yield, has the characteristics of less "three wastes" and less pollution, is another ideal way to achieve industrial production, and has strong market competitiveness.
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Description

technical field

[0001] The invention relates to a synthesis method of organic fine chemicals, in particular to a synthesis method of o-chlorobenzonitrile. Background technique

[0002] The traditional preparation methods of o-chlorobenzonitrile are generally prepared from corresponding aldehydes and aldoximes as raw materials. These methods have high raw material prices and serious environmental pollution.

[0003] O-chlorobenzonitrile (OCBN), also known as o-chlorobenzonitrile and 2-chlorobenzonitrile, is an important fine chemical and an intermediate in organic synthesis. Using o-chlorobenzonitrile as raw material, the corresponding o-chlorobenzylamine, o-chloroaniline, o-fluorobenzonitrile, o-fluorobenzoic acid, o-fluoroaniline, etc. can be prepared, which are widely used in dyestuff, medicine, pesticide and spice industries. It is an important intermediate in the synthesis of new antimalarial drug nitroquine, antihypertensive drug valsartan, uracil herbicides and phenyl...

Claims

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