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Method for synthesizing methionine through continuous and quick alkaline hydrolysis of 5-(beta-methylthioethyl)-hydantoin

A technology of methylthioethyl and hydantoin, which is applied in the chemical industry, can solve the problems of uneconomical, incomplete hydrolysis, and non-environmental protection, achieve high-selection and high-efficiency hydrolysis effects, and reduce by-product inorganic Salt, the effect of reducing production costs

Active Publication Date: 2019-11-08
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the shortcomings of the prior art described above, the object of the present invention is to provide a method for the continuous and efficient alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin to synthesize methionine, which has atom economy , used to solve the problem of the synthesis of methionine by alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin in the prior art, which produces many by-products, high reaction temperature, high temperature causes methionine to decompose, hydrolysis cannot be complete, and the reaction The rate is slow, resulting in the formation of colored impurities, insufficient reaction, not economical, resulting in waste of resources, not environmentally friendly, etc.

Method used

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  • Method for synthesizing methionine through continuous and quick alkaline hydrolysis of 5-(beta-methylthioethyl)-hydantoin
  • Method for synthesizing methionine through continuous and quick alkaline hydrolysis of 5-(beta-methylthioethyl)-hydantoin

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Embodiment 1

[0028]580.737 grams (0.5 moles) of 5-(β-methylthioethyl)-hydantoin aqueous solution with a mass percentage of 15 wt % and 76.013 grams (0.275 moles) of potassium carbonate aqueous solution with a mass percentage of 50 wt % (Potassium ion / 5-(β-methylthioethyl)-hydantoin=1.1 / 1) At the same time, it is pumped into the tubular reactor in the activation area through the metering pump, and the ultrasonic wave at the frequency of 25~30Hz, 80~120 Pre-activation at ℃ for 3~5min, the feed liquid enters the microchannel reactor after preactivation, and the flow rate of 5-(β-methylthioethyl)-hydantoin aqueous solution in the microchannel is 10.0ml / min. The flow rate of potassium carbonate aqueous solution in the microchannel is 1.31ml / min, the reaction temperature is controlled at 138°C, the pressure is 0.4MPa, the residence time is 3min (that is, the time for the reaction solution to flow through the microchannel), and the outflow liquid is clear and colorless 626.750 grams of transparen...

Embodiment 2

[0043] 580.737 grams (0.5 moles) of 5-(β-methylthioethyl)-hydantoin aqueous solution with a mass percentage content of 15 wt % and 44.0 grams (0.275 moles) of a 50 wt % sodium hydroxide aqueous solution ) (sodium ion / 5-(β-methylthioethyl)-hydantoin=1.1 / 1) at the same time pumped into the tubular reactor in the activation area through a metering pump, ultrasonic waves at a frequency of 25~30Hz, 80~ Pre-activation at 120°C for 3-5 minutes, after the pre-activation, the feed liquid enters the microchannel device, and the flow rate of the 5-(β-methylthioethyl)-hydantoin aqueous solution in the microchannel is 58.0ml / min. The flow rate of potassium carbonate aqueous solution in the microchannel is 2.197ml / min, the reaction temperature is controlled at 138°C, the pressure is 0.4MPa, and the residence time is 3min (that is, the time for the reaction solution to flow through the microchannel). The outflow liquid is clear and colorless 572.450 grams of transparent sodium methionine aqu...

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Abstract

The invention provides a method for synthesizing methionine through continuous and efficient alkaline hydrolysis of 5-(beta-methylthioethyl)-hydantoin. The method comprises the steps that alkali and a5-(beta-methylthioethyl)-hydantoin aqueous solution are pre-activated through a low-frequency ultrasonic wave and then are introduced into a microchannel reactor for hydrolysis reaction, the reactiontemperature is controlled to be 120-140 DEG C, the pressure is 0.2-0.8 MPa, the retention time of a reaction material in a microchannel is 2-5 min, and the DL-methionine is obtained. According to themethod, ultrasonic wave pre-activating and microchannel reaction are combined to be applied in a hydrolysis step, the high-selectivity and high-efficiency hydrolysis effect better than that of a traditional technology is obtained, adverse by-products such as dipeptide, diketopiperazine, acidamide and hydantoic acid which are unfavorable to a product are reduced greatly and especially, the raw material conversion rate is increased, the quality of final circulating mother liquor is improved, and the methionine is prepared for a long term stably and advantageously; and in addition, the using amount of alkali is further decreased to a certain extent, low-value byproduct inorganic salt is reduced, and the production cost of the methionine is lowered accordingly.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to a method for synthesizing methionine by continuous rapid alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin. [0002] technical background [0003] Methionine, also known as methionine, is one of the basic units of protein. It is the only amino acid containing sulfur among the essential amino acids. In addition to participating in the transfer of methyl groups in animals, the metabolism of phosphorus and the synthesis of adrenaline, choline, and creatine In addition, it is also a raw material for the synthesis of protein and cystine. Methionine is widely used in the fields of medicine, food, feed and cosmetics, among which the largest amount is used as a feed additive. In 2018, the demand for methionine in my country reached about 230,000 tons, and the import volume reached nearly 180,000 tons, nearly 80% of which The demand depends on imports, and the domestic production capa...

Claims

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Application Information

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IPC IPC(8): C07C319/20C07C323/58
CPCC07C319/20C07C323/58
Inventor 周荣超廖常福粟宇
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD