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A method for the synthesis of methionine by continuous rapid alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin

A technology of methylthioethyl and hydantoin, applied in the chemical industry, can solve the problems of lack of economical efficiency, incomplete hydrolysis and high reaction temperature, achieve high-selective and high-efficiency hydrolysis effects, and reduce by-product inorganic salts , the effect of improving yield

Active Publication Date: 2021-10-26
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the shortcomings of the prior art described above, the object of the present invention is to provide a method for the continuous and efficient alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin to synthesize methionine, which has atom economy , used to solve the problem of the synthesis of methionine by alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin in the prior art, which produces many by-products, high reaction temperature, high temperature causes methionine to decompose, hydrolysis cannot be complete, and the reaction The rate is slow, resulting in the formation of colored impurities, insufficient reaction, not economical, resulting in waste of resources, not environmentally friendly, etc.

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  • A method for the synthesis of methionine by continuous rapid alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin
  • A method for the synthesis of methionine by continuous rapid alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin

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Embodiment 1

[0028]5- (β-methylthioethylene)-Acetanoxy anhydrous solution 580.737 g (0.5 mol) with a water solution of 50% by weight (0.275 moles) (Potassium ion / 5- (β-methylthioethyl) - Ethyl urea = 1.1 / 1) simultaneously passes the tube reactor of the activation region at the same time, in the ultrasonic reactor of 25 to 30 Hz, 80 to 120 Pre-activated 3 to 5 min in an ° C, pre-activated end feed liquid into the microchannel reactor, 5- (β-methylthioethylene) -rythene flow rate of 10.0 mL / min, The potassium carbonate aqueous solution is 1.31 ml / min in the microchannel, and the reaction temperature is 138 ° C, the pressure is 0.4 MPa, the residence time is 3 min (i.e., the reaction flow is flowing through the microchannels), the flowing liquid is clear and colorless Transparent methionine solution 626.750 grams, wherein the mass content of potassium methionine is 14.94 wt%. After high performance liquid chromatography analysis, methionine dipeptide, methionine, membranine acid, and nake...

Embodiment 2

[0043] 5- (β-methylthioethylene)-Acetoxy aqueous solution of mass percentage of 15% by weight of 580.737 g (0.5 mol) and aqueous sodium hydroxide solution with a mass percentage of 50 wt% (0.275 moles) (Sodium Ion / 5- (β-methylthioethyl) -rytiocetoxylurea = 1.1 / 1) simultaneously passes the tube reactor of the active region, at 25 to 30 Hz frequency ultrasound, 80 ~ Pre-living in 120 ° C for 3 to 5 min, pre-active end material into the microchannel, 5- (β-methylthioethylene) -rythalonic acid solution researclic flow rate of 58.0 mL / min, The potassium carbonate aqueous solution is 2.197 ml / min in the microchannel, the control temperature is 138 ° C, the pressure is 0.4 MPa, the residence time is 3 min (i.e., the reaction flow flows through the microchannel time), the flow outflow is clear and colorless The transparent methionidate solution 572.450 grams, wherein the mass content of sodium methionine is 14.95 wt%. After high-performance liquid chromatography, methionptopine, m...

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Abstract

The invention provides a method for synthesizing methionine with continuous and efficient alkaline hydrolysis of 5-(β-methylthioethyl)-hydantoin, comprising: combining alkali with 5-(β-methylthioethyl)-hydantoin The aqueous urea solution is pre-activated by low-frequency ultrasonic waves and then passed into a microchannel reactor for hydrolysis reaction. The reaction temperature is controlled at 120°C-140°C, the pressure is 0.2MPa-0.8MPa, and the residence time of the reaction materials in the microchannel is 2-5min. DL‑methionine. The present invention combines ultrasonic preactivation and microchannel reaction in the hydrolysis step to obtain a high-selection and high-efficiency hydrolysis effect superior to the traditional process, and especially greatly reduces the unfavorable dipeptide, diketopiperazine, amide, seawater, etc. Due to unfavorable by-products such as acid, the conversion rate of raw materials and the quality of the final circulating mother liquor are improved, which is beneficial to the long-term and stable preparation of methionine; in addition, the amount of alkali used is reduced to a certain extent, and low-value by-product inorganic salts are reduced, correspondingly reducing Methionine production cost.

Description

Technical field [0001] The present invention relates to the field of chemical workers, and more particularly to a process for continuous fast alkali solution 5- (β-methionethylthylthylthyl)-ethyl urea synthesis methionine. [0002] technical background [0003] Methionine is also known as methionine, is one of the basic units of the protein, and is the essential amino acid in the amino acid containing sulfur-containing amino acid, except for metastasis, phosphorus metabolism, phosphorus metabolism, choline, and creatine synthesis In addition, it is still a raw material of protein and cystine. Methionine is widely used in the fields of medical, food, feed and cosmetics. Among them, as the maximum amount of feed additives, the demand for methionine in China has reached approximately 180,000 tons in 2018, and the import volume reached nearly 180,000 tons, nearly 80%. Demand relies on imports, domestic methionine production is only 150,000 tons, far from demand. [0004] 5- (β-methylt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C319/20C07C323/58
CPCC07C319/20C07C323/58
Inventor 周荣超廖常福粟宇
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD