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Preparation method of surface-enhanced raman scattering chip useful for trace detection, obtained product and an application

A surface-enhanced Raman and trace technology, applied in Raman scattering, measuring devices, instruments, etc., can solve the problems of complex preparation process and difficult storage of products, and achieve simple preparation of raw materials, good competitive advantages, and high-sensitivity detection Effect

Active Publication Date: 2019-11-12
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reported strategies have many disadvantages in practical application, such as complex preparation process, difficult storage of products, need to use special reagents or more complex instruments and equipment, etc.

Method used

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  • Preparation method of surface-enhanced raman scattering chip useful for trace detection, obtained product and an application
  • Preparation method of surface-enhanced raman scattering chip useful for trace detection, obtained product and an application
  • Preparation method of surface-enhanced raman scattering chip useful for trace detection, obtained product and an application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]Accurately weigh 800 mg of melamine and dissolve it in 250 mL of ultrapure water, and heat the solution to keep the temperature at 60±5 °C. Under stirring conditions, 50 mL of silver nitrate aqueous solution with a concentration of 38 mM was slowly poured into the above hot melamine aqueous solution, and continued to stir to obtain a colorless and transparent colloidal solution.

[0042] Take a substrate with a groove capacity of 10 μl, and use a pipette to quickly transfer 10 μl of the above colloid solution into each groove of the array substrate. The solvent in the grooves is completely evaporated, and the white dry gel film evenly covers the bottom of each groove. The above-mentioned substrate containing the xerogel film was transferred to a muffle furnace, and was slowly heated to 450 °C at a heating rate of 2 °C / min in an air atmosphere, and kept at this temperature for 180 min to remove organic components and make precious metals. The ions are reduced to a noble ...

Embodiment 2

[0044] Accurately weigh 400 mg of carbonamide and dissolve it in 250 mL of ultrapure water. Under stirring at room temperature, slowly pour 50 mL of silver nitrate aqueous solution with a concentration of 38 mM into the above carbonic amide aqueous solution, and continue to stir to obtain a colorless and transparent solution. colloidal solution.

[0045] Take a substrate with a groove capacity of 50 μl, and use a pipette to quickly transfer 50 μl of the above colloid solution into each groove of the array substrate. The solvent in the grooves is completely evaporated, and the white dry gel film evenly covers the bottom of each groove. The above-mentioned substrate containing the xerogel film was transferred to a muffle furnace, and was slowly heated to 400 °C at a heating rate of 5 °C / min under a nitrogen atmosphere, and kept at this temperature for 120 min to remove organic components and make precious metals. The ions are reduced to a noble metal thin film with a rough surf...

Embodiment 3

[0047] Accurately weigh 550 mg of thiourea and dissolve it in 250 mL of ultrapure water. Under stirring at room temperature, slowly pour 100 mL of sodium chloroaurate aqueous solution with a concentration of 20 mM into the above thiourea aqueous solution, and continue to stir to obtain a light solution. Yellow transparent colloidal solution.

[0048] Take a substrate with a groove capacity of 100 μl, and use a pipette to quickly transfer 100 μl of the above colloid solution into each groove of the array substrate. The solvent in the grooves is completely evaporated, and the light yellow dry gel film evenly covers the bottom of each groove. The above-mentioned substrate containing the xerogel film was transferred to a muffle furnace, and was slowly heated to 500 °C at a heating rate of 10 °C / min under air, and kept at this temperature for 60 min to remove organic components and make noble metal ions. It is reduced to a noble metal film with a rough surface, and then naturally ...

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Abstract

The invention discloses a preparation method of a surface-enhanced raman scattering chip useful for trace detection, an obtained product and an application. The method comprises the steps of enablingan amino-containing organic substance and a noble metal precursor to form a uniform vitreosol through a liquid phase reaction; and then transferring the vitreosol to a substrate with an array-type groove for in-situ aging reaction and heat treatment reaction to obtain the surface-enhanced raman scattering chip for detection, in which the bottom of the groove contains a uniform noble metal film. According to the preparation method of a surface-enhanced raman scattering chip useful for trace detection disclosed by the invention, the preparation material is easy to obtain, the process is simple,the surface-enhanced raman performance of the obtained chip is excellent, the advantages of large-scale production and application are obvious, and the chip is suitable for simple, rapid and sensitivedetection of the micro trace substance molecules.

Description

technical field [0001] The invention relates to a preparation method of a chip with excellent surface-enhanced Raman scattering performance that can be prepared at low cost and on a large scale, can be used for trace detection, and the obtained chip and application, belonging to the technical field of micro-trace analysis and detection. Background technique [0002] Surface-enhanced Raman scattering (SERS) is a Raman scattering signal enhancement that relies on the localized surface plasmon resonance of noble metal plasmons. This Raman scattering spectroscopy technique can significantly improve the detection signal intensity of the detection object and achieve trace level detection. Even single-molecule level analysis, detection and research can be achieved; at the same time, the enhancement of the signal can further broaden the application range of Raman spectroscopy. Therefore, considering the practical application, the key to the application of SERS technology depends on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65C23C18/42C23C18/16
CPCG01N21/658C23C18/42C23C18/1682C23C18/1678
Inventor 窦智峰赵鑫赵振东张名楠
Owner HAINAN UNIVERSITY
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