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Formula preparation for increasing bone density of obese animals and preparing method thereof

A technology of animal bones and preparations, applied in drug combinations, medical preparations containing active ingredients, bone diseases, etc., can solve the problems of no enhancement of bone density, high cost, poor compliance, etc., and achieve safe nutritional interventions Effect

Pending Publication Date: 2019-11-22
LIAOCHENG UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the slow rate of bone turnover, it takes a long time to improve the abnormal state of bone metabolism, which is accompanied by high cost and poor compliance
At present, the most commonly used nutritional supplements for improving bone density are various calcium tablets, vitamins and other substances, and no compound preparations of vitamin K2 and collagen have been found, nor have they been found to enhance bone density for obese people whose bone metabolism is different from that of the general population nutritional supplements

Method used

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  • Formula preparation for increasing bone density of obese animals and preparing method thereof
  • Formula preparation for increasing bone density of obese animals and preparing method thereof
  • Formula preparation for increasing bone density of obese animals and preparing method thereof

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Embodiment Construction

[0021] The present invention is based on the principle that vitamin K participates in blood coagulation, helps to promote osteocalcin carboxylation of γ-glutamic acid produced by osteoblasts, and then promotes bone formation by coupling carbonylated osteocalcin with phosphides. form. In addition, vitamin K2 can inhibit the reduction of osteoprotegerin and prevent the occurrence of osteoporosis. Type I collagen is an important building block of bone, is the main extracellular matrix protein for calcification, and also plays a role in osteoblast differentiation. A large number of research results including isotope tracer have shown that hydrolyzed collagen can not only improve bone density, but also improve cartilage tissue composition in animals. This phenomenon is related to the release and absorption of collagen-derived peptides that act on bone metabolism. In order to further verify the nutritional supplement of vitamin K2 and hydrolyzed collagen on the bone quality and bon...

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Abstract

The invention provides a formula preparation for increasing bone density of obese animals and a preparing method thereof. The preparation is formed by carrying out gradient dilution on vitamin K2 andthen mixing the diluted vitamin K2 with hydrolyzed collagen. Through a high fat diet induced obese mice animal model, changes of bone characteristics and bone metabolism related to osteoblasts and osteoclasts are analyzed particularly, and the effects of nutritional supplement of vitamin K2 and hydrolyzed collagen on mice bone substances and bone metabolism are verified. The formula preparation provides simple, convenient and safe nutrition intervention measures for common bone density reduction or bone metabolism imbalance in obese groups, and also provides scientific reference data for nutrition intervention of degenerative osteopathy of other groups.

Description

technical field [0001] The invention belongs to the technical field of food and nutrition industry, and in particular relates to a prescription preparation for increasing the bone density of obese animals and a preparation method thereof. Background technique [0002] Obesity is a metabolic disease resulting from increased intake of a high-calorie diet, decreased physical activity, and / or excessive intake of glucocorticoids. Come in, obesity has become a growing global public health problem. Studies have shown that obesity is associated with an increased risk of several chronic diseases including diabetes, hypertension, cardiovascular disease, abnormal lipid metabolism, asthma, osteoarthritis and cancer. [0003] Obesity has traditionally been thought to be beneficial for bone health because body weight positively affects the mechanical load on bone formation. But recent studies have found that decreased bone mineral density and increased incidence of fractures are more pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P3/04A61P19/10A61K31/122
CPCA61K38/39A61K31/122A61P3/04A61P19/10
Inventor 尹肖寒王正平
Owner LIAOCHENG UNIV