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Low-voltage high-performance electroosmotic micropump chip based on solid-state track etching nanopores

A nanoporous and electroosmotic pump technology, applied in laboratory containers, laboratory utensils, fluid controllers, etc., can solve the problems of difficult microfluidic chip integration, high working voltage, and complicated operation, and achieve stable flow rate without any problems. Attenuation, low operating voltage, simple operation effect

Active Publication Date: 2019-11-22
HUBEI UNIVERSITY OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention aims to solve the problems of complex operation, high working voltage, slow flow rate and difficulty in integrating with microfluidic chips in the process of fluid drive of the electroosmotic pump. High-performance electroosmotic micropump chip and its preparation method

Method used

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  • Low-voltage high-performance electroosmotic micropump chip based on solid-state track etching nanopores
  • Low-voltage high-performance electroosmotic micropump chip based on solid-state track etching nanopores
  • Low-voltage high-performance electroosmotic micropump chip based on solid-state track etching nanopores

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] Step 1. Preparation of solid-state nanopores: the preparation of solid-state nanopores adopts the track etching method, which is a preparation method based on high-energy heavy ion irradiation and chemical etching. First, high-energy heavy ions are used to irradiate the polymer film material to form a nano-scale sneak track composed of damaged areas in the polymer film material; then chemical etching is used to selectively etch the sneak track, thereby A nano-sized pore structure is obtained. The diameter, shape and density of track-etched nanopores can be highly controllable by adjusting the irradiation conditions and etching conditions.

[0032] The ion track polymer film used above is the ion track polymer film after the bombardment of 17MeV / u Ar ions from the UNILAC accelerator of the Lanzhou Institute of Modern Physics, Chinese Academy of Sciences. ), cut the polymer film into a number of discs with a diameter of 2 cm, and irradiate them in a CL-1000 ultraviolet c...

Embodiment 1

[0038] Example 1 When the operating voltage is 50V, the current test of the electroosmotic pump chip under different reaction solutions

[0039] The specific experimental process is as follows:

[0040] (1) Use a Pasteur pipette to take about 2ml of 0.1*TAE and add it to the electrode reaction column 1, 2 and the straight channel (a) of the chip, and seal the injection port with a sealing anti-collision sticker. During this operation, try to avoid air bubbles ; Insert platinum electrodes in the electrode reaction columns 1 and 2, connect the power supply and ammeter, set the voltage to 50V, and start timing after the circuit is connected. Currents were recorded every two minutes for one hour. During the experiment, pay attention to whether there is any leakage of the electroosmotic pump chip.

[0041] (2) After the recording is completed, turn off the voltage, take out the electrodes, empty the solution in the chip, and clean the electroosmotic pump chip with TAE at the next...

Embodiment 2

[0044] Example 2 Flow rate test of the electroosmotic pump chip under different reaction solutions and different voltages

[0045] The specific experimental process is as follows:

[0046] (1) Use a Pasteur pipette to take about 2ml of 0.1*TAE and add it to the electrode reaction column 1, 2 and the front section of the straight channel (a), and use a sealing anti-collision sticker to seal the injection port. During this operation, try to avoid air bubbles; Use a pipette gun to draw about 300 μL of diluted red ink and add it to the rear section of the straight channel (a), and seal the injection port with a sealing anti-collision sticker. During this operation, try to avoid generating air bubbles; in the electrode reaction column 1 and 2 Insert the platinum electrode, connect the power supply and the ammeter, set the voltage to 20V, and start timing after the circuit is connected. Record the advancing distance of the red ink in the channel (c) every two minutes; set the volta...

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Abstract

The invention discloses a low-voltage high-performance electroosmotic pump micro-fluidic chip based on solid-state track etching nanopores. The chip is composed of a micro-channel, a micro-electroosmotic pump, an electrode and an electrode reaction column. According to the design of the electroosmotic pump chip, an ultrathin nano-porous material is selected, the electrode placement position is improved, a reaction solution is optimized, and agarose gel is adopted for filling, so that the working voltage of the electroosmotic pump is lower (1-10 V), and the flow velocity is more stable. According to a chip type electroosmotic pump provided by the invention, the flow velocity and direction of a solution can be accurately controlled by adjusting the applied voltage; the flow velocity ranges from 0 [mu]l / min to 100 [mu]l / min; and the electroosmotic pump is integrated into the chip, so that the microfluidic chip has the advantages of miniaturization, easiness in operation, no moving part, low cost and the like; integration with an external channel, and other units, such as sample separation, mixing and analysis, in a microfluidic chip integrated laboratory can be achieved so as to obtain a microfluidic microchip integrated laboratory which truly does not need to be supported by an external fluid pump.

Description

technical field [0001] The invention belongs to the field of microelectromechanical systems, and relates to an electroosmotic pump microfluidic chip applied in the field of microfluidic control in the fields of medicine and chemical analysis, and a fluid drive system using the electroosmotic pump chip. Background technique [0002] Microfluidic chips have the advantages of precise fluid control, small sample requirements, rapid response and large-scale integration, making them a powerful tool for clinical diagnosis and disease screening. In recent years, microfluidic chips have been widely used in nucleic acid and protein analysis, cell culture, sorting, and drug screening. They can provide accurate, high-throughput, and easy-to-integrate application platforms for biomedical research. Fluidic chip system has developed into a new research field of interdisciplinary subjects such as biomedicine, electronics, materials, and fluids. [0003] Among the various micropumps manufac...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/50273B01L2200/12B01L2300/0816B01L2300/0883B01L2300/0887B01L2400/0475
Inventor 陈琴华任芳玲王册明罗丹冉凤英张斌强
Owner HUBEI UNIVERSITY OF MEDICINE
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