CMC/FA-chitosan hydrochloride composite nanoparticle, and preparation method and application thereof

A technology of chitosan hydrochloride and composite nanoparticles, which is applied in the field of emulsifiers to achieve low cost, good physical stability, and the effect of preventing droplet aggregation

Active Publication Date: 2019-11-29
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no document / patent report on making carboxymethyl cellulose and ferulic acid into a compound, and then compounding it with chitosan hydrochloride to prepare nanoparticles

Method used

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  • CMC/FA-chitosan hydrochloride composite nanoparticle, and preparation method and application thereof
  • CMC/FA-chitosan hydrochloride composite nanoparticle, and preparation method and application thereof
  • CMC/FA-chitosan hydrochloride composite nanoparticle, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. Preparation of carboxymethyl cellulose / ferulic acid complex

[0050] The carboxymethyl cellulose was dissolved in distilled water to obtain a 0.1 wt% carboxymethyl cellulose solution. The solution was continuously stirred at 250 rpm for 1 hour, and the pH was adjusted to 4. EDC and ferulic acid are dissolved in ethanol, its mixed solution is added dropwise in the carboxymethyl cellulose solution 250rpm continuous stirring 1 hour, the mol ratio of ferulic acid and carboxymethyl cellulose is 1:3 (the concrete dosage is respectively For: 10mg, 30mg), and the pH of the solution was adjusted to 4 using 0.1M hydrochloric acid.

[0051] 2. Preparation of carboxymethyl cellulose / ferulic acid-chitosan hydrochloride composite nanoparticles

[0052] Chitosan hydrochloride is placed on the stirrer and stirred and dissolved and the pH is adjusted to be 4 to obtain 0.2wt% chitosan hydrochloride solution; Ferulic acid complex solution was added dropwise to chitosan hydrochloride ...

Embodiment 2

[0057] 1. Preparation of carboxymethyl cellulose / ferulic acid complex

[0058] Carboxymethyl cellulose was dissolved in distilled water to obtain a 0.1 wt% carboxymethyl cellulose solution, stirred continuously at 250 rpm for 1 hour, and the pH was adjusted to 4. ED and ferulic acid are dissolved in ethanol, its mixed solution is added dropwise in the carboxymethyl cellulose solution 250rpm continuous stirring 1 hour, the mol ratio of ferulic acid and carboxymethyl cellulose is 1:2 (the specific dosage is respectively For: 10mg, 20mg), and use 0.1M hydrochloric acid to adjust the pH of the solution to 4.

[0059] 2. Preparation of carboxymethyl cellulose / ferulic acid-chitosan hydrochloride composite nanoparticles

[0060] Chitosan hydrochloride is placed on the stirrer and stirred and dissolved and the pH is adjusted to be 4 to obtain 0.2wt% chitosan hydrochloride solution; Ferulic acid complex solution was added dropwise to chitosan hydrochloride solution to obtain carboxym...

Embodiment 3

[0065] 1. Preparation of carboxymethyl cellulose / ferulic acid complex

[0066] Carboxymethyl cellulose was dissolved in distilled water to obtain a 0.1 wt% carboxymethyl cellulose solution, stirred continuously at 250 rpm for 1 hour, and the pH was adjusted to 4. ED and ferulic acid are dissolved in ethanol, its mixed solution is added dropwise in the carboxymethyl cellulose solution 250rpm continuous stirring 1 hour, the mol ratio of ferulic acid and carboxymethyl cellulose is 2:1 (the concrete consumption is respectively For: 20mg, 10mg), and the pH of the solution was adjusted to 4 using 0.1M hydrochloric acid.

[0067] 2. Preparation of carboxymethyl cellulose / ferulic acid-chitosan hydrochloride composite nanoparticles

[0068] Chitosan hydrochloride is placed on the stirrer and stirred and dissolved and the pH is adjusted to be 4 to obtain 0.2wt% chitosan hydrochloride solution; Ferulic acid complex solution was added dropwise to chitosan hydrochloride solution to obtai...

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Abstract

The invention discloses a preparation method for a CMC/FA-chitosan hydrochloride composite nanoparticle. The preparation method comprises the following steps: subjecting carboxymethyl cellulose and ferulic acid to an esterification reaction mediated by 1-ethyl-(3-dimethylaminopropyl)carbodiimide (EDC) under the condition of stirring at room temperature so as to form a carboxymethyl cellulose/ferulic acid complex; preparing a chitosan hydrochloride solution and preparing a carboxymethyl cellulose/ferulic acid complex solution; and subjecting the carboxymethyl cellulose/ferulic acid complex solution and the chitosan hydrochloride solution to a hybrid reaction under stirring to prepare the carboxymethyl cellulose/ferulic acid-chitosan hydrochloride composite nanoparticle. The invention also discloses a method for preparing a Pickering emulsion by using the composite nanoparticle. The composite nanoparticle provided by the invention has good dispersibility and emulsification properties; and the Pickering emulsion prepared by using the composite nanoparticle as an emulsifier has good physical stability and antioxidant activity, and can be widely used in food, medicine, cosmetics, and other fields.

Description

technical field [0001] The present invention relates to a preparation method of oil-water emulsion, in particular to a CMC / FA-chitosan hydrochloride composite nanoparticle, its preparation method and application, such as the use in the preparation of Pickering emulsion, which belongs to emulsifier technology field. Background technique [0002] Pickering emulsion is a type of emulsion stabilized by solid particles instead of surfactants. The stabilization mechanism is that nanoparticles, as stabilizers, are irreversibly adsorbed at the oil-water interface to provide a physical barrier, forming a film or coagulation of particle aggregates around the oil droplets. The colloidal structure improves the stability of Pickering emulsions to coalescence and Ostwald ripening. This mechanism endows Pickering emulsions with greater stability compared to small molecule surfactants and traditional emulsions stabilized with natural macromolecules. However, common problems such as biocom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08L1/28C08J3/12B82Y40/00A23P10/30A23L29/30
CPCA23V2002/00A23L29/30A23P10/30B82Y40/00C08J3/12C08J2305/08C08J2401/28A23V2250/51082A23V2250/511
Inventor 章宝孟然潘怡李小敏刘文杰李小龙
Owner HEFEI UNIV OF TECH
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