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Water-soluble modified chitosan and preparation method and application thereof

A chitosan, water-soluble technology, applied in the field of water-soluble modified chitosan and its preparation, can solve the problems of chitosan losing physical and chemical activity, destroying chitosan skeleton structure, etc., and achieving excellent biological properties , the effect of reducing pollution and strong anti-pollution ability

Pending Publication Date: 2019-12-10
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the modification of amino groups is simple and easy, in many cases it will destroy the original skeleton structure of chitosan and make chitosan lose its original physical and chemical activity.

Method used

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  • Water-soluble modified chitosan and preparation method and application thereof
  • Water-soluble modified chitosan and preparation method and application thereof
  • Water-soluble modified chitosan and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The present embodiment provides a kind of water-soluble modified chitosan, and its specific synthetic route is as follows:

[0043]

[0044] According to its synthetic route, the specific preparation process includes the following steps:

[0045] (1) chitosan is fully dissolved in the acetic acid solution, and the mixed solution is used as the basic reaction system;

[0046] (2) Preparation of monomer 2-methacryloyloxyethyl phosphorylcholine for subsequent use;

[0047] (3) Use argon to protect the entire basic reaction system, then slowly add the monomer 2-methacryloyloxyethyl phosphate choline prepared in step (2) dropwise into the basic reaction system, and stir until it reacts ;

[0048] (4) After the reaction is finished, the product obtained after the reaction is placed in deionized water for dialysis treatment, and after several cycles, the product is collected;

[0049](5) Subpackage the product obtained after dialysis in step (4), and perform freeze-dryin...

Embodiment 2

[0054] The present embodiment provides the water solubility experiment of the modified chitosan (CS-MCP) that above-mentioned embodiment prepares, concrete experiment is as follows:

[0055] The same mass of modified chitosan (CS-MCP) and common unmodified chitosan (CS) were dissolved in water at the same time, and the water solubility of the two was compared.

[0056] Experimental conclusions, the specific results are as follows image 3 As shown, the same mass of CS and CS-MCP are dissolved in the same volume of deionized water respectively, CS is insoluble in deionized water and precipitates at the bottom in the form of particles, even after ultrasonic oscillation and heat treatment, CS is still insoluble; and the invention obtains The chitosan derivative CS-MCP is fully dissolved in deionized water, and the derivative is dissolved in deionized water to form a uniform viscous liquid.

[0057] Tests show that at room temperature, the water solubility of the modified chitosa...

Embodiment 3

[0059] On the basis of the above examples, this example further provides a new method for synthesizing the monomer 2-methacryloyloxyethyl phosphorylcholine.

[0060] The synthetic route of monomer 2-methacryloyloxyethyl phosphorylcholine (MCP) is as follows:

[0061]

[0062] According to its synthetic route, its specific preparation method is as follows:

[0063] Glass instruments were dried with a flame gun and protected with argon before doing chemical synthesis reactions. Add 8mmol of methanol and 8mmol of triethylamine to a 25mL round bottom flask, then add 5mL of chromatographic-grade tetrahydrofuran (THF) as a solvent, and then place the mixed solution in an ice-salt bath to lower the temperature of the solution to -20°C , because COP is easy to open the ring at high temperature and has many side reactions at high temperature, it is necessary to lower the solution temperature to -20 °C. Mix 8mmol of 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) with 5mL of chromatogr...

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Abstract

The invention discloses water-soluble modified chitosan, and belongs to the technical field of macromolecular compound modification. The water-soluble modified chitosan is prepared by Michael additionreaction of 2-methacryloyloxyethyl choline phosphate and chitosan, the specific structure is that the modified chitosan can be applied to the preparation of skin wound dressing, drug carriers and antibacterial coating agents. The modified chitosan is soluble in water and has good water solubility, the use of an acid solution is avoided, side effects are reduced, and environmental pollution is reduced; reaction is only conducted on the amino group of the chitosan, an original skeleton of the chitosan is retained, and the original physical and chemical activity of the chitosan cannot be lost; the 2-methacryloyloxyethyl choline phosphate is introduced, and more excellent biological property is achieved on the chitosan; and the preparationmethod of the modified chitosan is simple and easy tooperate, the experimental conditions are mild, the yield of finished products is high, the water-soluble modified chitosan is of great guiding significance for industrial production and application, and is suitable for wide application and popularization.

Description

technical field [0001] The invention relates to the technical field of polymer compound modification, in particular to a water-soluble modified chitosan and its preparation method and application. Background technique [0002] The chitosan molecular chain contains a large number of active groups such as amino groups and hydroxyl groups. These groups can be used to perform various chemical modifications on chitosan, such as alkylation reactions, quaternization reactions, carboxymethyl reactions, and ring opening. reaction and acylation reaction to obtain water-soluble or organic-soluble chitosan derivatives, such modified chitosan derivatives can be used in biomedical fields such as skin wound dressings, drug carriers, and antibacterial. [0003] Various existing technologies for modifying chitosan are to improve its solubility, charge and other physical properties through chemical modification of its amino and hydroxyl groups. It includes grafting hydrophilic or hydrophobic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 翁杰卢敏陈星羽
Owner SOUTHWEST JIAOTONG UNIV
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