Traditional Chinese medicine component composition for treating and/or preventing liver and gall diseases and application thereof

A technology of traditional Chinese medicine components and liver and gallbladder diseases, applied in the field of traditional Chinese medicine, can solve the problems of uncontrollable quality, large dosage, inconvenience, etc., and achieve the effect of easy quality control, excellent curative effect, and small quality difference

Active Publication Date: 2019-12-20
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Both the traditional Yinchenhao Decoction and Huangqi Decoction are formulated according to prescriptions. This method has many shortcomings such as large dosage, inconvenient, uncontrollable quality, etc.

Method used

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  • Traditional Chinese medicine component composition for treating and/or preventing liver and gall diseases and application thereof
  • Traditional Chinese medicine component composition for treating and/or preventing liver and gall diseases and application thereof
  • Traditional Chinese medicine component composition for treating and/or preventing liver and gall diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Comparative Study on Therapeutic Effects of Yinchenhao Decoction Components on Rats with Cholestatic Liver Injury Induced by ANIT

[0043] 1.1.1 Animals

[0044] Seventy-six male Wistar rats, 6 weeks old, SPF grade, were purchased from Shanghai Xipuer-Bikai Experimental Animal Co., Ltd., license number: SCXK (Shanghai) 2013-0016, batch number 2008001657852.

[0045] 1.1.2 Drugs

[0046] Artemisia annua, purchased from Shanghai Yutiancheng Chinese Herbal Pieces Co., Ltd., raw material origin Shaanxi, production batch number: 2013012303. Raw gardenia, purchased from Shanghai Huayu Pharmaceutical Co., Ltd., raw material origin Jiangxi, production batch number: 2012110001. Rhubarb was purchased from Shanghai Leiyunshang Traditional Chinese Medicine Pieces Factory, the origin of raw materials is Gansu, production batch number: 20121001508. Gallic acid, lot number 160277, purity: >98%; rhubarb polysaccharide, lot number 160409, purity: >90%; chlorogenic acid, lo...

Embodiment 2

[0077] Example 2: Study on the therapeutic effect of Huangqi decoction and its components on rats with cholestatic liver injury induced by ANIT

[0078] 1.1.1 Animals

[0079] Thirty-nine male Wistar rats, 6 weeks old, SPF grade, were purchased from Shanghai Xipuer-Bikai Experimental Animal Co., Ltd., license number: SCXK (Shanghai) 2013-0016, batch number 2008001657852.

[0080] 1.1.2 Drugs

[0081] Astragalus decoction granules, the research group commissioned Jiangyin Tianjiang Pharmaceutical Co., Ltd. to prepare, production batch number: 1212353. Specifications: Each gram of Huangqi Decoction Granules contains 5.263g of crude drug, and each bag weighs 1.96g. The clinical dosage of crude drug of Huangqi Decoction for 65kg body weight adult is 0.538g / kg.

[0082] Astragalus total saponins, calculated as astragaloside IV, the purity of Astragalus total saponins determined by spectrophotometry is 61.2%. The dose of total astragalus saponins is the best effect dose obtained...

Embodiment 3

[0110] Example 3: Research on the effect of CRGA component compound on regulating bile acid transporter and nuclear hormone receptor in the treatment of cholestasis

[0111] The research results of Example 1 and Example 2 suggest that chlorogenic acid (C), gallic acid (R), rhubarb polysaccharide (G), and total saponins of Astragalus (A) are the effective agents of Yinchenhao Decoction and Huangqi Decoction in the treatment of chronic cholestasis. Main effect components. The four active ingredients used alone can regulate the expression of bile acid transporter and bile acid ligand (nuclear hormone receptor, TGR5), and improve the enterohepatic circulation of bile acid. The research content of this chapter, taking Yinchenhao Decoction, Huangqi Decoction, and ursodeoxycholic acid as positive control drugs, explored whether the combination of the four components to form a CRGA component compound could exert a synergistic effect in the treatment of cholestasis.

[0112] 1 Materia...

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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine component composition for treating and / or preventing liver and gall diseases. The composition is composed of chlorogenic acid, gallic acid, rhubarb polysaccharide and total saponins of astragalus membranaceus, and the weight part ratio of the chlorogenic acid to the gallic acid to the rhubarb polysaccharide to the total saponins of astragalus membranaceus, is 1:0.2:0.2:0.2 to 1:10:20:30. The invention has the advantages that: the CRGA component medicine can effectively improve the liver function of chronic cholestasis serum, reduce the content of hydroxyproline in liver tissue, and relieve inflammatory injury of liver tissue, interlobular biliary duct hyperplasia and collagenous fiber deposition, the curative effect is superior to that of a combination formula of raw medicinal materials, the medicine components are clear, and the quality is easy to control.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine component composition for treating and / or preventing liver and gallbladder diseases and its application. Background technique [0002] Cholestasis refers to the pathological state of bile formation, secretion and excretion disorders caused by various reasons inside and outside the liver, and the bile flow cannot normally flow into the duodenum and enter the blood, causing damage to liver cells and the body. Long-term development can lead to liver fibrosis, liver cirrhosis, and liver failure, and has an important pathological indicator role for chronic liver diseases. The treatment of cholestatic liver disease is still an international problem so far, and most of the existing therapeutic drugs have limited efficacy. Therefore, it is of great social significance to search for drugs for the treatment of cholestasis. [0003] Yinchenhao Dec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P1/16A61K31/216A61K31/192A61K31/715
CPCA61K31/192A61K31/216A61K31/715A61K36/481A61P1/16A61K2300/00
Inventor 王晓柠刘平闫晶瑜戚莉邱剑楠刘佳杜曾
Owner SHANGHAI UNIV OF T C M
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