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Medical material and method for preparing anticoagulation coating on surface of medical material

An anticoagulant and coating technology, which is applied in the field of medical devices, can solve problems such as difficult to meet the requirements of process productization, high requirements for the environment and operators, and damage to the surface structure of medical materials, so as to achieve good molecular chain stretching performance, Easy to apply and promote, destroy the effect of environmental protection and energy saving

Active Publication Date: 2019-12-20
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method needs to use a strong oxidizing solution, which can easily cause great damage to the surface structure of medical materials, and has high requirements for the environment and operators.
In addition, the medical materials suitable for this method are very limited, such as polytetrafluoroethylene, polypropylene and other materials, it is difficult to obtain satisfactory results
In addition to this method, there are also reports of multi-layer stacking, ionic bond electrostatic adsorption, plasma treatment, photochemical grafting and other treatment methods, but there are various disadvantages, such as the process is relatively complicated, it is difficult to popularize and apply, or the anticoagulant activity is unstable. etc., it is difficult to meet the use requirements of process productization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In this embodiment, the method of preparing a heparin coating on the inner and outer surfaces of a polyvinyl chloride pipe with an outer diameter of 8 mm and an inner diameter of 6 mm is taken as an example.

[0029] First, the surface of the PVC pipe is soaked with azidohexanoic acid with a concentration of 1% by mass, then taken out, and placed under a 365nm ultraviolet light source for 60 minutes. After the irradiation is completed, the PVC pipe is rinsed with purified water to produce Polyvinyl chloride pipe with amino sensitive sites on the surface.

[0030] Next, prepare 100 mL of an aqueous solution of tetraethylenepentamine with a concentration of 0.01% by mass, and immerse the polyvinyl chloride pipe grafted with azidohexanoic acid in the aqueous solution of tetraethylenepentamine, soak and stir for 60min at 25°C. After soaking and taking out, the polyvinyl chloride pipe is rinsed with purified water to prepare a polyvinyl chloride pipe with an amino extension chain...

Embodiment 2

[0034] In this embodiment, the method of preparing a heparin coating on the surface of a polyethylene film with a thickness of 0.2 mm is taken as an example.

[0035] First, prepare 50 mL of an azidoacetic acid solution with a concentration of 2% by mass. The polyethylene film is soaked in the azidoacetic acid solution and taken out, and irradiated under a 254nm ultraviolet light source for 20 minutes. After the irradiation is completed, the polyethylene film is rinsed with purified water A clean polyethylene film with amino-sensitive sites on the surface was prepared.

[0036] Next, prepare 50 mL of a 0.01% mass concentration polyethyleneimine aqueous solution, immerse the polyethylene film grafted with azidoacetic acid in the polyethyleneimine aqueous solution, soak and stir for 30 minutes at 30°C, and take it out after the soaking is complete. Rinse the polyethylene film with purified water to obtain a polyethylene film with amino extension chains on the surface.

[0037] Finally...

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Abstract

The invention discloses a medical material and a method for preparing an anticoagulation coating on the surface of the medical material. The method comprises the following steps: S1, grafting an azidecompound on the surface of the medical material so as to form amino sensitive sites on the surface of the medical material; S2, grafting a polymeric amino compound on the surface of the medical material obtained in the step S1 so as to form an elongated chain with multiple amino groups on the surface of the medical material; and S3, grafting heparin on the surface of the medical material obtainedin the step S2, so as to form the anticoagulation coating on the surface of the medical material. The method disclosed by the invention is simple in operation step, small in material amount, safe inmaterial and good in biocompatibility, and the obtained medical material is high in anticoagulation activity and stable in long term use.

Description

Technical field [0001] The present invention relates to the field of medical devices, in particular to a medical material and a method for preparing an anticoagulant coating on its surface. Background technique [0002] Medical device products, such as vascular stents, extracorporeal blood circulation pumps, venous indwelling tubes, artificial blood vessels, etc., can easily stimulate the blood clotting mechanism and form thrombus when used in clinical applications, which seriously affects the safety of the device. The development of simple and efficient heparin coating technology on the surface of medical materials can promote the blood compatibility and anticoagulant properties of medical materials, which can greatly reduce the occurrence of thrombosis in medical products, thereby ensuring the therapeutic effect. At present, heparin anticoagulation coating technology for medical materials is being developed and applied more and more widely. [0003] O. Larm et al. reported that ...

Claims

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Application Information

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IPC IPC(8): A61L33/10A61L33/00
CPCA61L33/0082A61L33/0023A61L33/08A61L2420/02C08L5/10
Inventor 陆威康亚红冯德军白维刚张国艺姜洪焱罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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