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Selenium/silica/gold nano composite particles as well as preparation method and application thereof

A silicon dioxide and composite particle technology, applied in the direction of sulfur/selenium/tellurium active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc. Good, uniform appearance, and the effect of reducing side effects

Inactive Publication Date: 2019-12-31
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the direct use of Se in clinical medicine has some limitations, such as the safe use range of Se is very small, and the effect of eliminating solid tumors in a short period of time is not so effective

Method used

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  • Selenium/silica/gold nano composite particles as well as preparation method and application thereof
  • Selenium/silica/gold nano composite particles as well as preparation method and application thereof
  • Selenium/silica/gold nano composite particles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A kind of selenium / silicon dioxide / gold nanocomposite particle and preparation method thereof, its process is:

[0059] (1) Synthesis of Se / SiO Nanospheres Se@SiO 2 ; Specific operation steps such as (1.1) ~ (1.4):

[0060] (1.1) Disperse 43.5mg of selenium powder in oleic acid and heat to 120°C (T 1 ) while passing nitrogen for 5min(t 1 ), the temperature was raised to 280°C (T 2 ), kept under stirring conditions for 30min(t 2 ), obtain Se-OA precursor, wherein, the mass volume ratio of selenium powder and oleic acid is 8mg:1mL;

[0061] (1.2) Dissolve CuCl in a mixed solvent of oleylamine and oleic acid to obtain a mixed solution, and heat it to 120°C (T 3 ) while passing nitrogen for 5min(t 3 ), the temperature was raised to 220°C (T 4 ), kept under stirring conditions for 10min(t 4 ), inject the Se-OA precursor obtained in step (1.1) into it, and continue to stir for 5min (t 5 ), generating Cu 2-x Se, x is 0~1, and wherein, the volume ratio of oleic acid a...

Embodiment 2

[0082] A kind of application of selenium / silicon dioxide / gold nanocomposite particle, the Se@SiO that embodiment 1 makes 2 @Au-PEG nanocomposite particles are used for photothermal therapy, the specific process is: the Se@SiO 2 @Au-PEG nanocomposite particles were dissolved in a PBS solution with a pH of 7.4 and a concentration of 1 mg / mL, and injected 200 μL of the solution into the mouse body through the tail vein. After 12 hours, the material was highly enriched in the tumor area, and the power density was used to 1W / cm 2 The 808nm laser was used to irradiate the tumor site for 10 minutes for photothermal therapy.

Embodiment 3

[0084] A kind of application of selenium / silicon dioxide / gold nanocomposite particle, the Se@SiO that embodiment 1 makes 2 @Au-PEG nanocomposite particles are used for drug sustained release, the specific process is: 4mg Se@SiO 2 @Au-PEG nanocomposite particles were dispersed in 4 mL of DOX solution with a concentration of 1 mg / mL, stirred in the dark for 36-48 h, collected by centrifugation, washed with deionized water three times to remove free DOX, and formed Se@SiO2@Au / DOX-PEG nanocomposite particles act on the body with Se@SiO2@Au / DOX-PEG nanocomposite particles.

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Abstract

The invention relates to selenium / silica / gold nano composite particles as well as a preparation method and application thereof. The preparation method comprises the following steps: synthesizing selenium / silica nano-spheres, which are mainly formed by silica spheres and Se quantum dots dispersed in the silica spheres, through an inverse micro emulsion method, and coating the surfaces of the selenium / silica nano-spheres with mesoporous gold shells through a gold seed growth method to prepare the selenium / silica / gold nano composite particles. The selenium / silica / gold nano composite particles prepared with the method are mainly formed by the selenium / porous silica nano-spheres and the mesoporous gold shells coating the surfaces of the selenium / porous silica nano-spheres, the selenium / porous silica nano-spheres are mainly formed by porous silica spheres and Se quantum dots dispersed in the porous silica spheres, and the average particle size of the selenium / silica / gold nano composite particles is 90-100nm; and finally the prepared selenium / silica / gold nano composite particles are used for photothermal therapy, drug sustained release and CT imaging. The method is mild in reaction condition, the photothermal conversion efficiency of the prepared nano composite particles is high, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanocomposite particles, and relates to a selenium / silicon dioxide / gold nanocomposite particle and a preparation method and application thereof. Background technique [0002] In recent years, affected by environmental pollution and changes in people's lifestyles, cancer cases are increasing year by year, and cancer is increasingly threatening people's health. Existing cancer treatment methods mainly include surgical treatment, chemotherapy and radiotherapy, etc., but these methods cannot completely eliminate cancer cells and cause serious toxic side effects to normal tissues and cells of the body. At the same time, photothermal therapy (photothermal therapy) based on nanomaterials and nanotechnology has attracted widespread attention. Photothermal materials can convert near-infrared light into thermal effects, which can improve treatment efficiency without causing side effects, which has gi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K33/04A61K41/00A61K49/04A61P35/00
CPCA61K9/5115A61K33/04A61K41/0052A61K49/04A61P35/00A61K2300/00
Inventor 刘锡建孔文艳陆杰
Owner SHANGHAI UNIV OF ENG SCI
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