Preparation method of vitamin C granules in Rosa roxburghii

A technology for granules and vitamins, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of expensive natural vitamin C, laborious grinding and stirring, and decreased extraction rate. Achieve the effect of short preparation time, not easy to stick to the wall, and good effect

Pending Publication Date: 2019-12-31
HUBEI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Rosa roxburghii is the fruit of the silk flower of the Rosaceae plant. It is a well-known variety for both medicine and food. It is known as the king of vitamin C because it is rich in vitamin C. Vitamin C has reducing properties and is unstable when exposed to heat. In the heating and reflux extraction process, the extraction rate decreases with the increase of temperature, so ultrasonic extraction is often used, and grinding and stirring can also be used, but grinding and stirring are laborious, and the loss rate is higher than ultrasonic extraction.
[0003] There are two main types of vitamin C-related products on the market today, one is OTC drug-grade vitamin C, and the other is natural vitamin C in health food products. The investigation found that drug-grade vitamin C has high purity, but because it is It is synthesized by microorganisms, and its activity is poor compared with natural vitamin C, and the price of natural vitamin C on the market is generally expensive. Obtaining natural vitamin C from cheap and easy-to-obtain raw materials is an urgent need of the masses. Rosa roxburghii is a wild plant , is widely distributed in the country, and its vitamin C content is more than 2.5%. Dosage forms will provide a reliable path for the development and industrial production of vitamin C innovative dosage forms

Method used

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  • Preparation method of vitamin C granules in Rosa roxburghii
  • Preparation method of vitamin C granules in Rosa roxburghii
  • Preparation method of vitamin C granules in Rosa roxburghii

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Configure an aqueous solution containing 0.2% oxalic acid and 5% sodium chloride as an extractant, weigh 2g of Rosa roxburghii dried fruit, add 100ml of extractant, and perform flash extraction of Rosa roxburghii dried fruit in an ultrasonic environment, wherein the extraction temperature is 30°C. The extraction time is 40min, the ultrasonic frequency is 60%, the extraction time of the flash extractor is 60s, and the voltage is 100V. After filtration, the filtrate is concentrated by rotary evaporation; take the above filtrate and add 100ml of 75% ethanol, let it stand for precipitation, and remove the insoluble ethanol. Sugar, such as chitosan, is filtered and the filtrate is rotovapped to obtain the extract concentrate.

[0023] With starch slurry as binder and maltodextrin as diluent, add an appropriate amount of the above-mentioned concentrated extract into the mortar, then add an appropriate amount of diluent, and mix uniformly by equal addition method (so that the t...

Embodiment 2

[0025] Configure an aqueous solution containing 0.2% oxalic acid as an extractant, weigh 2g of Rosa roxburghii dry fruit, add 100ml of extractant, and perform flash extraction on the Rosa roxburghii dry fruit in an ultrasonic environment, wherein the extraction temperature is 30°C, the extraction time is 40min, and the ultrasonic frequency 60%, the extraction time of the flash extractor is 60s, and the voltage is 100V. After filtration, the filtrate is concentrated by rotary evaporation; the above-mentioned filtrate is added to 100ml75% ethanol, left to settle, and sugars that are not compatible with ethanol, such as chitosan, are removed. After filtration, the filtrate was rotary evaporated to obtain the extract concentrate.

[0026] With starch slurry as binder and maltodextrin as diluent, add an appropriate amount of the above-mentioned concentrated extract into the mortar, then add an appropriate amount of diluent, and mix uniformly by equal addition method (so that the tho...

Embodiment 3

[0029] Configure an aqueous solution containing 0.2% oxalic acid and 5% sodium chloride as an extractant, weigh 2g of Rosa roxburghii dried fruit, add 100ml of extractant, and perform flash extraction of Rosa roxburghii dried fruit in an ultrasonic environment, wherein the extraction temperature is 30°C. The extraction time is 40min, the ultrasonic frequency is 60%, the extraction time of the flash extractor is 60s, and the voltage is 100V. After filtration, the filtrate is concentrated by rotary evaporation; take the above filtrate and add 100ml of 75% ethanol, let it stand for precipitation, and remove the insoluble ethanol. Sugar, such as chitosan, is filtered and the filtrate is rotovapped to obtain the extract concentrate.

[0030] Using starch slurry as a binder, using β-cyclodextrin, soluble starch, and maltodextrin as a diluent respectively, add an appropriate amount of the above-mentioned concentrated extract in a mortar, and then add an appropriate amount of diluent, ...

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Abstract

The invention discloses a preparation method of vitamin C granules in Rosa roxburghii, which comprises the following steps: (1) by using a sodium chloride solution containing oxalic acid as an extractant, extracting dried Rosa roxburghii fruits by using a flash extractor under ultrasonic conditions, filtering the material, and carrying out rotary evaporation concentration on a filtrate; (2) addingethanol into the filtrate, filtering the amterial, and carrying out rotary evaporation on the obtained filtrate to remove ethanol; (3) adding a diluent and an adhesive into the concentrated solutionobtained in the step (2), and obtaining the granules through spray drying. The vitamin C extraction rate is high, the vitamin C extraction speed is high, the extracted vitamin C is not prone to inactivation, the preparation process of the granules is simple, the dosage form of the vitamin C is optimized, and the granules are economical, practical and good in clustering performance.

Description

technical field [0001] The invention relates to the field of granule preparations, in particular to a method for preparing vitamin C granules from Rosa roxburghii. Background technique [0002] Rosa roxburghii is the fruit of the silk flower of the Rosaceae plant. It is a well-known variety for both medicine and food. It is known as the king of vitamin C because it is rich in vitamin C. Vitamin C has reducing properties and is unstable when exposed to heat. During the heating and reflux extraction process, the extraction rate decreases with the increase of temperature. Therefore, ultrasonic extraction is often used, and grinding and stirring can also be used, but grinding and stirring are laborious, and the loss rate is higher than that of ultrasonic extraction. [0003] There are two main types of vitamin C-related products on the market today, one is OTC drug-grade vitamin C, and the other is natural vitamin C in health food products. The survey found that drug-grade vitam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/375A61K36/738A61K9/16A61K47/36C07D307/62
CPCA61K31/375A61K36/738A61K9/1652C07D307/62
Inventor 范宝磊屈曾义韦国良甘小风徐胜李婷婷刘明胜
Owner HUBEI UNIV OF SCI & TECH
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