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Cannabidiol-containing composition and preparation method thereof

A cannabidiol and preparation technology, which is applied in the field of cannabidiol-containing compositions and its preparation, can solve the problems of cannabidiol instability and low bioavailability, and achieve good appearance, good stability, and preparation conditions mild effect

Active Publication Date: 2020-01-03
辰风天然本草(北京)科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of cannabidiol instability and low bioavailability, the first purpose of the present invention is to provide a high stability preparation of cannabidiol

Method used

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  • Cannabidiol-containing composition and preparation method thereof
  • Cannabidiol-containing composition and preparation method thereof
  • Cannabidiol-containing composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]

[0037] The preparation method includes the following steps:

[0038] S1. Mix soybean lecithin, polyglyceryl-10 stearate and medium-chain triglycerides, stir and heat at 65°C and 500 rpm for 1 hour to obtain a light yellow oily liquid, which is the first mixed oil phase;

[0039] S2. Add cannabidiol to the first mixed oil phase, continue to stir and heat at 65° C. and 500 rpm for 15 minutes, and fully mix under the protection of nitrogen to obtain an oily liquid, which is the second mixed oil phase;

[0040] S3. Weigh gamma cyclodextrin, glycerin and distilled water in a weight ratio, and then mix them thoroughly at 40°C and 500 rpm to obtain a clear aqueous solution, which is the water phase;

[0041] S4. Disperse the second mixed oil phase dropwise into the water phase until the dispersion is complete, and then use high shear to obtain a light yellow opaque emulsion, which is a cannabidiol crude emulsion;

[0042] S5. The crude cannabidiol emulsion was homogenized under high p...

Embodiment 2

[0045]

[0046] The preparation method includes the following steps:

[0047] S1. Mix soybean lecithin, polyglyceryl-10 stearate and medium chain triglycerides (MCT), stir and heat for 1 hour at 65°C and 1000 rpm to obtain a light yellow oily liquid, which is the first mixed oil phase;

[0048] S2. Add cannabidiol to the first mixed oil phase, continue to stir and heat at 65° C. and 1000 rpm for 15 minutes, and fully mix under the protection of nitrogen to obtain an oily liquid, which is the second mixed oil phase;

[0049] S3. Weigh gamma cyclodextrin, glycerin and distilled water in a weight ratio, and then mix them thoroughly at 40°C and 1000 rpm to obtain a clear aqueous solution, which is the water phase;

[0050] S4. Disperse the second mixed oil phase dropwise into the water phase until the dispersion is complete, and then use high shear to obtain a light yellow opaque emulsion, which is a cannabidiol crude emulsion;

[0051] S5. The cannabidiol crude emulsion was homogenized und...

Embodiment 3

[0053]

[0054] The preparation method includes the following steps:

[0055] S1. Mix soybean lecithin, polyglyceryl-10 stearate and medium chain triglycerides (MCT), stir and heat for 1 hour at 65°C and 1000 rpm to obtain a light yellow oily liquid, which is the first mixed oil phase;

[0056] S2. Add cannabidiol to the first mixed oil phase, continue to stir and heat at 65° C. and 1000 rpm for 15 minutes, and fully mix under the protection of nitrogen to obtain an oily liquid, which is the second mixed oil phase;

[0057] S3. Weigh gamma cyclodextrin, glycerin and distilled water in a weight ratio, and then mix them thoroughly at 40°C and 1000 rpm to obtain a clear aqueous solution, which is the water phase;

[0058] S4. Disperse the second mixed oil phase dropwise into the water phase until the dispersion is complete, and then use high shear to obtain a light yellow opaque emulsion, which is a cannabidiol crude emulsion;

[0059] S5. The crude cannabidiol emulsion is homogenized unde...

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Abstract

The invention relates to a highly stable preparation of cannabidiol and a preparation method thereof. The highly stable preparation is prepared from the following raw materials in parts by weight: 0.1-10 parts of cannabidiol, 5-15 parts of medium chain triglyceride (MCT), 1-15 parts of soybean lecithin, 1-20 parts of gamma-cyclodextrin, 10-20 parts of glycerol-10 stearate, 10-45 parts of glycerol,and balance of distilled water. According to the preparation method, cannabidiol is prepared into the highly stable preparation through nano-encapsulation technology. The highly stable preparation not only retains original structure and activity of cannabidiol, but also maximizes absorption and utilization of cannabidiol, greatly improves bioavailability of cannabidiol, expands application rangeof cannabidiol, and provides reliable technical support for downstream market applications and formulation development.

Description

Technical field [0001] The invention relates to a composition, particularly a composition containing cannabidiol (CBD) and a preparation method thereof, and belongs to the field of biotechnology. Background technique [0002] Cannabidiol (Cannabidiol, referred to as CBD) is a non-psychoactive ingredient extracted from cannabis (Cannabis sativa L.). It does not cause physical dependence and has good tolerance. It is resistant to mental illness, epilepsy, tumors, sclerosis, Various diseases and symptoms such as anorexia, glaucoma, diabetes, liver injury, inflammation and pain have shown certain therapeutic properties, and have shown broad application prospects in the fields of medicine, health food, food, and cosmetics. [0003] Because cannabidiol is a highly lipophilic component, its application and bioavailability in water-based products have certain limitations. At the same time, in order to make it more stable and durable in clinical application For drug activity, we use nanoem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/05A61P1/14A61P1/16A61P3/10A61P25/00A61P25/08A61P27/06A61P29/00A61P35/00A61P37/02
CPCA61K9/1075A61K31/05A61P1/14A61P1/16A61P3/10A61P25/00A61P25/08A61P27/06A61P29/00A61P35/00A61P37/02
Inventor 孟令超梁浩吴启林
Owner 辰风天然本草(北京)科技有限公司
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