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Vitamin E (VE) solid tablet and preparation method thereof

A technology of vitamins and solids, which is applied in the fields of anti-toxic agents, pill delivery, and pharmaceutical formulations. It can solve problems such as insecurity, poor comfort, and side effects, and achieve the effects of no discomfort, uniform content, and balanced intake

Active Publication Date: 2020-01-03
SHANDONG FOOD & FERMENT IND RES & DESIGN INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the current vitamin E is a capsule containing vitamin solution. Due to the limitation of processing technology, the existing vitamin solid tablet is not comfortable to take. It is not only unsafe to take for a long time, but also has side effects.

Method used

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  • Vitamin E (VE) solid tablet and preparation method thereof
  • Vitamin E (VE) solid tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The vitamin E solid tablet of this embodiment includes the following raw materials in terms of weight fractions: hydroxypropyl cellulose: 50 parts, vitamin E: 1.5 parts, maltodextrin: 45.1 parts, white sugar: 2 parts, microcrystalline cellulose 1 0.1 part of ethyl maltol, 0.2 part of magnesium stearate and 0.1 part of aspartame.

[0029] The vitamin E solid tablet described in this embodiment is prepared through the following steps:

[0030] S1. Add all the above-mentioned raw materials to the mixer for full mixing;

[0031] S2, granulation: the mixed raw and auxiliary materials in step S6 are granulated through a granulator;

[0032] S3. Tablet compression: the prepared granules in step S7 are compressed by a tablet machine to obtain solid vitamin E tablets.

Embodiment 2

[0034] The vitamin E solid tablet of this embodiment includes the following raw materials in terms of weight fractions: octadecanoyl octadecanoic acid pullulan ester: 42 parts, vitamin E: 1.6 parts, maltodextrin: 53 parts, white granulated sugar : 2 parts, microcrystalline cellulose: 1 part, ethyl maltol: 0.1 part, magnesium stearate: 0.2 part and aspartame: 0.1 part. Wherein, the chemical molecular formula of octadecanoyl octadecanoate pullulan is:

[0035]

[0036] The vitamin E solid tablet described in this embodiment is prepared through the following steps:

[0037] S1. Swelling: Add octadecanoyl octadecanoic acid pullulan ester to water, the ratio of octadecanoyl octadecanoic acid pullulan ester to water is 1:25, and the swelling time is 5 hours, and the first A solution, the first solution is;

[0038] S2. Mixing: Add the raw material vitamin E into the first solution in step S1, and stir for 30 minutes through a high-speed stirring disperser, and the working speed...

Embodiment 3

[0046]Octadecanoyl octadecanoate pullulan: 45 parts, vitamin E: 2.0 parts, maltodextrin: 49.6 parts, white sugar: 2 parts, microcrystalline cellulose: 1 part, ethyl maltol: 0.1 parts, magnesium stearate: 0.2 parts and aspartame: 0.1 parts.

[0047] The vitamin E solid tablet described in this embodiment is prepared through the following steps:

[0048] S1. Swelling: Add octadecanoyl octadecanoic acid pullulan ester to water, the ratio of octadecanoyl octadecanoic acid pullulan ester to water is 1:25, and the swelling time is 5 hours, and the first A solution, the first solution is;

[0049] S2. Mixing: Add the raw material vitamin E into the first solution in step S1, and stir for 30 minutes through a high-speed stirring disperser, and the working speed of the high-speed stirring disperser is 1200r / min, to obtain the second solution;

[0050] S3, high-pressure homogenization: the vitamin E dispersion in step S2 is carried out high-pressure homogenization by a high-pressure h...

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Abstract

The invention discloses a vitamin solid tablet and a preparation method thereof. A vitamin E solid tablet provided by the invention is prepared from the following raw materials in parts by weight: 40-45 parts of stearoyl stearic acid pullulan ester, 1.5-2 parts of a VE, 45-55 parts of maltodextrin and the balance of ingredients. The invention further provides a preparation method of the VE solid tablet. The preparation method comprises the following steps: S1, swelling; S2, mixing; S3, high-pressure homogenization; S4, remixing; S5, spray drying; S6, mixing; S7, pelleting; and S8, tableting. According to the VE solid tablet, the content of the VE in each solid tablet is more uniform, the daily vitamin intake of a taker can be more balanced, the VE solid tablet is compact in structure and not prone to being disintegrated and just melts in the mouth during taking, and uncomfortableness is avoided.

Description

technical field [0001] The invention relates to the technical field of vitamin E preparation, in particular to a vitamin E solid tablet and a preparation method thereof. Background technique [0002] Natural vitamin E (VE) is a fat-soluble vitamin, also known as tocopherol, a commonly used medicine and health care product, and one of the most important natural antioxidants. Soluble in fat and isobutane and other extractants, insoluble in water, stable to heat and acid, unstable to alkali, sensitive to oxygen, not sensitive to heat, but the activity of vitamin E is significantly reduced when fried. Tocopherol can promote the secretion of sex hormones, increase the vitality and quantity of sperm in men; increase the concentration of estrogen in women, improve fertility, prevent miscarriage, and can also be used to prevent and treat male infertility, burns, frostbite, capillary bleeding, menopausal syndrome, Beauty and other aspects have a very good curative effect. Recently,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K47/12A61K47/22A61K31/355A61P39/06
CPCA61K9/2013A61K9/2018A61K9/2054A61K9/2059A61K31/355A61P39/06
Inventor 孙曙光兰文忠冀利苏理贺晓芳
Owner SHANDONG FOOD & FERMENT IND RES & DESIGN INST
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