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Device and method for preparing calcium alginate microspheres by using micro-reactor, and applications thereof

A calcium alginate, microreactor technology, applied in chemical instruments and methods, chemical/physical/physical-chemical reactors, pharmaceutical formulations, etc., can solve the problems of mutual adsorption of droplets, uneven flow rate, etc., and achieve uniform particle size. , The effect of large reaction area and controllable swelling ratio

Active Publication Date: 2020-01-03
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors have found that the essence of this method is the reaction between the aqueous phase calcium ions and the aqueous phase sodium alginate. When reacting in the S-shaped channel, the flow rate in the S-shaped tube is different due to the fact that the liquid droplets need to flow through the tubes with different angles. Uniform, it is easy to cause adjacent droplets to adsorb each other and fuse to form larger droplets; in all the above methods, calcium ions and sodium alginate are dissolved in aqueous solution, which are essentially two-phase reactions; currently used methods Among them, there is no technical means to dissolve calcium ions and sodium alginate in oil and water to react respectively; in order to solve the above problems, a kind of calcium alginate microspheres stabilized into balls through oil-water two-phase reaction is needed. Preparation method and formula

Method used

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  • Device and method for preparing calcium alginate microspheres by using micro-reactor, and applications thereof
  • Device and method for preparing calcium alginate microspheres by using micro-reactor, and applications thereof
  • Device and method for preparing calcium alginate microspheres by using micro-reactor, and applications thereof

Examples

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Effect test

Embodiment 1

[0048] refer to figure 1 , an example of a device for preparing calcium alginate microspheres designed based on a microreactor in the present invention, including: a bottom plate 1, a first dispensing needle 2, a second dispensing needle 3, an inner phase glass tube 4, and an outer phase glass Tube 5 and collection culture dish 6; The first dispensing needle 2 and the second dispensing needle 3 are fixed side by side on the bottom plate 1, and a port of the inner phase glass tube 4 is connected with the cavity of the first dispensing needle 2 One port of the outer phase glass tube 5 communicates with the cavity of the second dispensing needle 3, and the other port of the inner phase glass tube 4 passes through the cavity of the second dispensing needle 3 and then extends into the outer phase glass In the tube 5 ; the other port of the outer phase glass tube 5 is located in the collection petri dish 6 , and the central axis of the outer phase glass tube 5 is perpendicular to th...

Embodiment 2

[0054] A device for preparing calcium alginate microspheres based on a microreactor, the same as in Example 1, the difference is that it also includes syringes for injecting the internal phase fluid and the external phase fluid respectively, the first dispensing needle 2, the second point The glue needles 3 are respectively connected with a syringe, and flow pumps are used to drive the respective syringes, so as to inject the inner phase fluid and the outer phase fluid into the first glue dispensing needle 2 and the second glue dispensing needle 3 respectively.

Embodiment 3

[0056] A device for preparing calcium alginate microspheres based on a microreactor, the same as in Example 2, the difference is that the bottom plate is a glass slide of the 7101 type, and the inner phase glass tube 4 and the outer phase glass tube 5 are both 100 mm in length A capillary glass tube, and the inner diameter of the inner glass tube 4 is 0.1 mm, and the inner diameter of the outer glass tube 5 is 0.5 mm. The inner phase glass tube 4 and the outer phase glass tube 5 are fixed together with the glass slide by gluing.

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Abstract

The invention relates to the technical field of calcium alginate microsphere preparation, and especially relates to a device and a method for preparing calcium alginate microspheres by using a micro-reactor, and applications thereof. The method comprises the following steps: (1) an outer-phase fluid is introduced into a second dispensing needle head, and then enters an outer-phase glass tube, andan inner-phase fluid is introduced through a first dispensing needle head and an inner-phase glass tube when the outer-phase fluid flows out of the outlet of the outer-phase glass tube; (2) the inner-phase fluid forms liquid drops coated with the outer-phase fluid at the outlet of the inner-phase glass tube under the action of shearing force of the outer-phase fluid, and the liquid drops flow intoa collecting culture dish along with the outer-phase fluid; and 3) the position of a chip is continuously moved during collection to separate the liquid drops collected in the culture dish from eachother, and the obtained liquid drops stands after the collection is completed in order to move the redundant outer-phase fluid and obtain the calcium alginate microspheres. The device and the method are realized by using the micro-reactor, and the calcium alginate microspheres prepared by utilizing an oil phase and a water phase have the characteristics of uniform particle size, good sphericity degree and controllable swelling ratio, and can well meet the applications in the fields of drug loading, catalysis and detection.

Description

technical field [0001] The invention relates to the technical field of preparing calcium alginate microspheres, in particular to a device, method and application for preparing calcium alginate microspheres based on a microfluidic chip. Background technique [0002] The information disclosed in the Background of the Invention is only intended to increase the understanding of the general background of the invention, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes the prior art that is already known to those skilled in the art. [0003] Alginate is a natural polysaccharide extracted from brown algae. Calcium alginate microspheres can be obtained after alginate reacts with calcium ions. Alginate microspheres have good biocompatibility and biodegradability, and are widely used in food, pharmaceutical and medical testing and other fields. The microspheres produced by traditional techniques (such as spray drying me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00B01L3/00A61K9/16A61K47/36
CPCA61K9/1652B01J19/0093B01J2219/00013B01L3/5027
Inventor 满佳张善国张松李建勇李剑峰王晓杰
Owner SHANDONG UNIV
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