High-strength polyvinyl alcohol gel and preparation method and application thereof

A polyvinyl alcohol gel, polyvinyl alcohol technology, applied in the fields of materials and biomaterials, can solve the problems of insufficient effectiveness, safety and quality controllability, the gel cannot meet cartilage implantation, excessive boron release and other problems, Achieve the effect of ensuring biological safety, strengthening mechanical properties, and strong pressure resistance

Active Publication Date: 2020-01-03
IMEIK TECH DEV CO LTD
View PDF14 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the method of double cross-linking, Chinese patent CN105327382A discloses a method for preparing medical transparent polyvinyl alcohol hydrogel using a double cross-linking method of freezing cross-linking and borax chemical cross-linking, but the borax introduced in this patent has certain There is a risk of excessive release of boron during long-term implantation, and because borax and polyvinyl alcohol are cross-linked to form a ring structure, the cross-linking site is too rigid and not tough enough, resulting in gel Cannot meet the requirements of cartilage implantation
Therefore, the polyvinyl alcohol gel prepared by the prior art still has obvious deficiencies in the effectiveness, safety and quality controllability when used as artificial cartilage or soft tissue implant materials.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-strength polyvinyl alcohol gel and preparation method and application thereof
  • High-strength polyvinyl alcohol gel and preparation method and application thereof
  • High-strength polyvinyl alcohol gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The preparation of embodiment 1 polyvinyl alcohol gel

[0060] The polyvinyl alcohol (PVA) used in this example was purchased from Aladdin Company, with a weight average molecular weight of 120 kDa, a molecular weight distribution of 1.5, and an alcoholysis degree of 99.4%.

[0061] 1 # polyvinyl alcohol gel

[0062] 1) Preparation of PVA aqueous solution: weigh 25g of PVA into a 250mL three-neck flask, add 100mL of purified water, place the flask in a water bath at 95°C, heat and stir until the PVA is completely dissolved, and obtain the PVA aqueous solution. use;

[0063] 2) Chemical crosslinking: Weigh 15g of PVA aqueous solution in a 100mL beaker, add 1.5mL of NaOH solution (15.0wt.%) to the above PVA aqueous solution, stir evenly, then add 60mg of BDDE, continue stirring evenly, Fill into the mold, seal and place the PVA sample in a water bath at 25°C for chemical crosslinking for 24 hours;

[0064] 3) Physical cross-linking: after chemical cross-linking in a...

experiment example 1

[0090] The unconfined compressive modulus of experimental example 1 polyvinyl alcohol gel

[0091] With the 1 prepared in the embodiment of the present invention 1 # polyvinyl alcohol gel, 2 # The C1 prepared in polyvinyl alcohol gel, comparative example # Polyvinyl alcohol gel and C2 # Polyvinyl alcohol gel is typical, and the unconfined compression modulus is tested by UTM6202 electronic universal tensile machine equipment. details as follows:

[0092] The above samples were made into a cylindrical polyvinyl alcohol gel with a diameter of 0.85 cm and a height of 1 cm, and the unconfined compression modulus was tested; testing conditions: compression speed 50 mm / min, maximum deformation 60%. 1 prepared in Example 1 # polyvinyl alcohol gel, 2# The C1 prepared in polyvinyl alcohol gel, comparative example # Polyvinyl alcohol gel and C2 # The relationship between stress and compression displacement of polyvinyl alcohol gel is as follows: figure 1 , figure 2 , image 3...

experiment example 2

[0098] Experimental Example 2 Unconfined Cyclic Compression of Polyvinyl Alcohol Gel

[0099] With the 1 prepared in the embodiment of the present invention 1 # The C3 prepared in polyvinyl alcohol gel, comparative example 2 # Polyvinyl alcohol gel is typical, and the UTM6202 electronic universal tensile machine equipment is used to detect unconfined cycle compression. details as follows:

[0100] The above sample was made into a cylindrical polyvinyl alcohol gel with a diameter of 0.85 cm and a height of 1 cm, and the unconfined compression modulus was tested; test conditions: compression speed 50 mm / min, maximum deformation amount 60%, cyclic compression 10 times, and observed coagulation Whether the glue will crumble. 1 prepared in Example 1 # The C3 prepared in polyvinyl alcohol gel, comparative example 1 # The unconfined cycle compression test results of both polyvinyl alcohol gels are listed in Table 2.

[0101] Table 2 Unconfined cyclic compression test results of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
shear modulusaaaaaaaaaa
Login to view more

Abstract

The invention relates to a high-strength polyvinyl alcohol gel and a preparation method and application thereof. The method for preparing the high-strength polyvinyl alcohol gel comprises the following steps: a) carrying out a crosslinking reaction of a polyvinyl alcohol aqueous solution in the presence of a crosslinking agent and a catalyst to obtain a polyvinyl alcohol primary gel; and b) performing repeated freezing and thawing treatment on the polyvinyl alcohol primary gel to obtain the polyvinyl alcohol gel, wherein the crosslinking agent is selected from multiple epoxy compounds, and a mass ratio of the crosslinking agent to polyvinyl alcohol in the polyvinyl alcohol aqueous solution is 0.001-5:1. The multiple epoxy compounds are used to carry out chemical crosslinking, biosafety ofthe polyvinyl alcohol gel is guaranteed, and strong guarantees for flexibility and stability of the polyvinyl alcohol gel are provided. Combination of chemical crosslinking and freeze-thaw cycle physical crosslinking gives the polyvinyl alcohol gel better mechanical properties, and better strength, flexibility and stability, and application needs of the polyvinyl alcohol gel in the artificial cartilage or soft tissue aspect is more conducive to meet.

Description

technical field [0001] The invention relates to the field of materials and biomaterials, in particular to a high-strength polyvinyl alcohol gel and a preparation method and application thereof. Background technique [0002] Injuries and lesions of articular cartilage are common diseases in clinical orthopedics. Due to the extremely limited self-repair ability of articular cartilage, once damage or lesions occur, it is difficult to heal itself, and cartilage replacement must be performed. Clinically, artificial total joint replacement is widely used, and its clinical achievements have greatly benefited patients with osteoarthritis, but there are also various surgical complications. At present, the commonly used metal, ultra-high molecular weight polyethylene anti-wear joint prosthesis, silicone rubber, and polyurethane joint cushion materials have disadvantages such as easy wear and loosening, poor interface lubricity, and easy aging. [0003] In recent years, polyvinyl alco...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L29/04C08K5/1515A61L27/52A61L27/50A61L27/16
CPCC08J3/075C08J3/24A61L27/52A61L27/50A61L27/16C08J2329/04C08K5/1515A61L2430/06A61L2430/34
Inventor 谢文艳李睿智李亦晨
Owner IMEIK TECH DEV CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap