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Method for preparing clenbuterol hydrochloride molecularly imprinted polymer microspheres

A technology of clenbuterol hydrochloride and molecular imprinting, which is applied in the field of preparation of clenbuterol hydrochloride molecularly imprinted polymer microspheres, can solve the problem of reducing the amount of organic surfactant used, complex preparation methods, and clenbuterol hydrochloride molecular imprinting technology. Issues such as low yield of imprinted polymers

Active Publication Date: 2020-01-14
GUANGDONG RES INSTITITUTE OF PETROCHEM & FINE CHEM ENG
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  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to overcome the problems existing in the prior art, the object of the present invention is to provide a method for preparing clenbuterol hydrochloride molecularly imprinted polymer microspheres. Molecularly imprinted microspheres with regular shapes can be formed, and the usage of organic surfactants can be greatly reduced by using Pickering emulsion polymerization, thus solving the problem of low yield of clenbuterol hydrochloride molecularly imprinted polymers and complicated preparation methods. serious environmental pollution

Method used

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  • Method for preparing clenbuterol hydrochloride molecularly imprinted polymer microspheres
  • Method for preparing clenbuterol hydrochloride molecularly imprinted polymer microspheres
  • Method for preparing clenbuterol hydrochloride molecularly imprinted polymer microspheres

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Embodiment 1

[0070] see figure 1 , the preparation method of molecularly imprinted polymer microspheres in this example is as follows:

[0071] 1) Add 0.12mL methacrylic acid (analytical grade), 6mL (0.3% by volume) polyethylene glycol octyl phenyl ether (analytical grade) to a stoppered glass vial, 20mg Aerosil 200nm silica nanoparticles (purity is 99%), 1.88mL ethylene glycol dimethacrylate (analytical pure), 10mg clenbuterol hydrochloride (analytical pure), 0.2mL toluene (analytical pure), 10mg azobisisobutyronitrile (analytical pure) Pure), the mixture was ultrasonically homogenized for 10 min, and shaken vigorously by hand for 6 min to obtain a uniform emulsion.

[0072] 2) Free radical polymerization: The emulsion was reacted in a water bath at 70°C for 12 hours to allow free radical polymerization of methacrylic acid and ethylene glycol dimethacrylate under the action of the initiator azobisisobutyronitrile to obtain For the sinking microspheres, wash the microspheres repeatedly w...

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Abstract

The invention discloses a method for preparing clenbuterol hydrochloride molecularly imprinted polymer microspheres. The preparation method comprises the following steps: 1) mixing a non-ionic surfactant solution, clenbuterol hydrochloride, a pore-forming agent, an initiator, inorganic nanoparticles, mono-ene monomers and polyene monomers, and performing homogenization to form an emulsion; 2) heating the emulsion to react so as to obtain polymer microspheres; 3) washing the polymer microspheres, further soaking the microspheres in an acid solution, taking out the microspheres, and cleaning andremoving the acid solution so as to obtain template removed microspheres; and 4) performing Soxhlet extraction on the template removed microspheres, and performing drying, so as to obtain the clenbuterol hydrochloride molecularly imprinted polymer microspheres. The preparation method disclosed by the invention is simple and convenient and is cost saving and environment-friendly. The prepared clenbuterol hydrochloride molecularly imprinted polymer microspheres have good uniformity, strong specific adsorption ability and high stability, and have broad application prospects in fields such as food safety detection and environmental remediation.

Description

technical field [0001] The invention relates to the technical field of functional polymer materials, in particular to a preparation method of clenbuterol hydrochloride molecularly imprinted polymer microspheres. Background technique [0002] Clenbuterol hydrochloride (Clenbuterol, CLB), is a β-receptor agonist (also known as β-stimulant), widely used in the treatment of bronchial diseases such as asthma, emphysema, chronic bronchitis, etc., and The most worrying thing about CLB is not its therapeutic effect, but its ability to promote growth, increase lean mass, reduce skeletal muscle fat and significantly improve carcass quality. Therefore, clenbuterol hydrochloride is used by unscrupulous manufacturers as a feed additive for the rapid growth of poultry and livestock in order to seek maximum benefits. CLB's "Clenbuterol" title also comes from this. However, once CLB is used as a feed additive, it will accumulate in animals, and humans are extremely vulnerable to threats f...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F222/14C08F2/30C08F2/24C08J9/26G01N30/56G01N30/60B01J20/26B01J20/30
CPCB01J20/261B01J20/268C08F2/24C08F2/30C08F220/06C08J9/26C08J2201/0424C08J2333/02G01N30/56G01N30/6052G01N2030/562
Inventor 麦裕良赵向云户华文黄淋佳
Owner GUANGDONG RES INSTITITUTE OF PETROCHEM & FINE CHEM ENG
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