Sunscreen cream containing cannabidiol lipidosome and preparation method
A cannabidiol resin and cannabidiol nanotechnology, which is applied in the field of sunscreen and preparation of cannabidiol liposomes, can solve the problems of insolubility of cannabidiol in water and the like, and achieves increased transdermal absorption efficiency and bioavailability degree of protection, good sunscreen effect, non-greasy skin
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Embodiment 1
[0026] (1) The preparation of cannabidiol liposomes comprises the following steps:
[0027] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 100 mg of phospholipid and 20 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain the organic phase.
[0028] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.1 MPa.
[0029] ③Hydration: Slowly add 10ml of 0.01mol / L phosphate buffer (pH6.5) into the phospholipid film container, and continue rotary steaming for 1 hour to make the phospholipid film fall off to obtain cannabidiol liposome suspension.
[0030] ④ Homogenization: inject the above suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 30MPa, after homogeniza...
Embodiment 2
[0038] (1) The preparation of cannabidiol liposomes comprises the following steps:
[0039] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 200 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.
[0040] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.2 MPa.
[0041] ③Hydration: Slowly add 15ml of 0.02mol / L phosphate buffer (pH7.0) into the phospholipid film container, and continue rotary steaming for 2 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.
[0042] ④ Homogenization: inject the above suspension into a high-pressure homogenizer to homogenize twice, the homogenization pressure is 40MPa, after homogenization, filt...
Embodiment 3
[0050] (1) The preparation of cannabidiol liposomes comprises the following steps:
[0051] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 300 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.
[0052] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.3 MPa.
[0053] ③Hydration: Slowly add 20ml of 0.02mol / L phosphate buffer (pH7.5) into the phospholipid film container, and continue rotary steaming for 3 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.
[0054] ④ Homogenization: inject the above suspension into a high-pressure homogenizer to homogenize twice, the homogenization pressure is 40MPa, after homogenization, filt...
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Abstract
Description
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Application Information
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