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Sunscreen cream containing cannabidiol lipidosome and preparation method

A cannabidiol resin and cannabidiol nanotechnology, which is applied in the field of sunscreen and preparation of cannabidiol liposomes, can solve the problems of insolubility of cannabidiol in water and the like, and achieves increased transdermal absorption efficiency and bioavailability degree of protection, good sunscreen effect, non-greasy skin

Inactive Publication Date: 2020-01-21
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One object of the present invention is to use liposome technology to prepare nano-sized cannabidiol, solve the problem of cannabidiol being insoluble in water, and increase the transdermal absorption effect of cannabidiol while improving its water solubility and stability. It allows CBD to quickly and effectively penetrate the surface of the skin, reach the deep layer of the skin and release CBD slowly, and the effect is obviously longer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) The preparation of cannabidiol liposomes comprises the following steps:

[0027] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 100 mg of phospholipid and 20 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain the organic phase.

[0028] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.1 MPa.

[0029] ③Hydration: Slowly add 10ml of 0.01mol / L phosphate buffer (pH6.5) into the phospholipid film container, and continue rotary steaming for 1 hour to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0030] ④ Homogenization: inject the above suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 30MPa, after homogeniza...

Embodiment 2

[0038] (1) The preparation of cannabidiol liposomes comprises the following steps:

[0039] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 200 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0040] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.2 MPa.

[0041] ③Hydration: Slowly add 15ml of 0.02mol / L phosphate buffer (pH7.0) into the phospholipid film container, and continue rotary steaming for 2 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0042] ④ Homogenization: inject the above suspension into a high-pressure homogenizer to homogenize twice, the homogenization pressure is 40MPa, after homogenization, filt...

Embodiment 3

[0050] (1) The preparation of cannabidiol liposomes comprises the following steps:

[0051] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 300 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0052] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.3 MPa.

[0053] ③Hydration: Slowly add 20ml of 0.02mol / L phosphate buffer (pH7.5) into the phospholipid film container, and continue rotary steaming for 3 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0054] ④ Homogenization: inject the above suspension into a high-pressure homogenizer to homogenize twice, the homogenization pressure is 40MPa, after homogenization, filt...

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Abstract

The invention discloses a sunscreen cream containing a cannabidiol lipidosome and a preparation method. The sunscreen cream is prepared from the following components in percentage by weight: 0.5 to 2percent of cannabidiol lipidosome, 0.5 to 8 percent of titanium dioxide, 1 to 8 percent of diethylamino hydroxy benzoyl hexyl benzoate, 0.5 to 10 percent of isoamyl 4-methoxycinnamate, 1 to 5 percentof ethylhexyl salicylate, 0.5 to 1.5 percent of ethylhexyl palmitate, 2 to 6 percent of glycerin monostearate, 0.5 to 2.5 percent of cetostearyl alcohol, 1 to 10 percent of glycerinum, 1 to 5 percentof butanediol, 0.1 to 1 percent of allantoin, 0.1 to 2 percent of tocopheryl acetate, 0.01 to 0.5 percent of xanthan gum, 0.01 to 0.2 percent of EDTA-2Na, 0.01 to 0.1 percent of preservative, and thebalance deionized water. According to the sunscreen cream containing the cannabidiol lipidosome and the preparation method provided by the invention, the nanoscale cannabidiol lipidosome is prepared by adopting a lipidosome embedding technique, so that the water solubility and the stability of cannabidiol (CBD) are improved, meanwhile, a transdermal absorption effect of the CBD is effectively promoted, the CBD can quickly penetrate through a skin surface layer, directly arrives at a skin deep layer and is slowly released, and the efficacy is durable. The sunscreen cream containing the nanoscale cannabidiol lipidosome provided by the invention has a better sunscreen effect and is capable of effectively scavenging free radicals and delaying skin aging, and the skin is fresh and cool withoutgreasy feeling after being applied with the sunscreen cream.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a sunscreen containing cannabidiol liposome and a preparation method thereof. Background technique [0002] Human skin, especially the facial skin, will damage the epidermal cells after excessive exposure to ultraviolet rays. After ultraviolet rays penetrate into the skin, harmful free radicals will be produced. These free radicals will damage the elastic fibers of the skin, cause skin relaxation, accelerate aging, and stimulate melanin. Increased secretion of cells, resulting in increased synthesis of melanin, resulting in pigmentation, such as dark spots, freckles, chloasma and other spots that increase, increase, and darken; under strong exposure, it can also cause skin inflammation, burns, and severe It can cause skin relaxation, roughness and wrinkle formation, telangiectasia, and erythema; it can also reduce skin immune function and form skin cancer or precanc...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/49A61K8/37A61K8/34A61K8/29A61K8/14A61Q17/04A61Q19/08
CPCA61K8/14A61K8/29A61K8/347A61K8/37A61K8/4946A61K8/678A61K2800/413A61K2800/56A61Q17/04A61Q19/08
Inventor 王钲霖刘胜贵薛红芬付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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