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Lactobacillus reuteri LR-CO21 and application thereof

A technology of LR-CO21 and Lactobacillus reuteri, applied in the field of probiotics, can solve the problems of acid-producing ability, stress resistance and bacteriostatic performance cannot be excellent at the same time, difficult TGEV infection, poor comprehensive performance, etc. The ability of piglets to resist virus infection or bacterial infection, good adhesion, and the effect of improving piglet immunity

Active Publication Date: 2020-01-31
NORTHEAST AGRICULTURAL UNIVERSITY
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AI Technical Summary

Problems solved by technology

However, vaccination wastes labor costs, and the use of antibiotics or drugs can easily lead to drug resistance of pathogens and antibiotic or drug residues. Probiotics can regulate intestinal flora, regulate mucosal and immune system functions, and promote nutrient absorption. Lactobacillus reuteri can produce a broad-spectrum antibacterial substance reuterin, which is more and more widely used
However, the currently commonly used Lactobacillus reuteri has poor comprehensive performance, for example: acid production ability, stress resistance, and antibacterial performance cannot be excellent at the same time, and its colonization effect in the intestinal tract is poor, and it is difficult to efficiently inhibit TGEV after colonization Infection, as a probiotic application, its comprehensive performance is poor

Method used

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  • Lactobacillus reuteri LR-CO21 and application thereof
  • Lactobacillus reuteri LR-CO21 and application thereof
  • Lactobacillus reuteri LR-CO21 and application thereof

Examples

Experimental program
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Effect test

Embodiment

[0155] The preserved Lactobacillus reuteri LR-CO21 was liquid inoculated and activated for 3 generations, inoculated into 500mL MRS culture medium at a volume ratio of 1:100, and cultured statically at 37°C for 24h. Aseptically dispense into 50mL centrifuge tubes, centrifuge at 4°C and 5000rpm / min, collect the bacteria, suspend the bacteria sediment with 20mL normal saline, and make the concentration of the bacteria solution 5×10 9 CFU / mL, ready for use at 4°C.

[0156] In the experiment, 24 newborn piglets aged 3 days old were selected from Du, and they were randomly divided into 3 groups according to the principle of similar body weight and litter source, with 8 pigs in each group. feeding group) and Lactobacillus reuteri + ETEC infection group (infection group). Each newborn piglet in the feeding group was given Lactobacillus reuteri (5×10 9 CFU / mL, 2 mL / head·day), and the other two groups were fed with the same amount of normal saline every day. Continuous gavage for 7 ...

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Abstract

The invention provides Lactobacillus reuteri LR-CO21 and application thereof and relates to the technical field of probiotics. The preservation number of the Lactobacillus reuteri LR-CO21 in the ChinaGeneral Microbiological Culture Collection Center is CCTCC No.M 2019601. The Lactobacillus reuteri LR-CO21 has good transplanting performance and adhesion in an intestinal tract and is capable of effectively inhibiting TGEV (transmissible gastroenteritis virus) infection and improving the ability and immunity of piglets in resisting virus infection and bacterial infection after transplanting. Inaddition, the invention further provides a method for applying the Lactobacillus reuteri LR-CO21 strain in improving the ability of piglets in resisting infectious diseases.

Description

technical field [0001] The invention relates to the technical field of probiotics, in particular to Lactobacillus reuteri LR-CO21 and its application. Background technique [0002] Porcine colibacillosis, porcine transmissible gastroenteritis and other diseases are important diseases that affect the economic benefits of the breeding industry. Among them, porcine colibacillosis is an intestinal infectious disease caused by pathogenic Escherichia coli, and porcine transmissible gastroenteritis is An infectious disease characterized by diarrhea, vomiting, and dehydration caused by porcine transmissible gastroenteritis virus (TGEV). At present, the prevention and control of the above diseases are mainly through vaccination, the use of antibiotics, drugs or probiotics and other methods. However, vaccination wastes labor costs, and the use of antibiotics or drugs can easily lead to drug resistance of pathogens and antibiotic or drug residues. Probiotics can regulate intestinal fl...

Claims

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Application Information

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IPC IPC(8): C12N1/20A23K10/18A23K50/30A61K35/747A61P1/00A61P37/04A61P31/14A61P31/04C12R1/225
CPCA23K10/18A23K50/30A61K35/747A61P1/00A61P37/04A61P31/14A61P31/04C12R2001/225C12N1/205A23V2400/173
Inventor 唐丽杰徐义刚李一经宋丽影解伟纯崔文姜艳平乔薪媛王丽周晗
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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