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Upconversion nanocomposite material, preparation method and application for dual dynamic synergistic therapy

A technology of nanocomposite materials and nanomaterials, applied in the field of nanobiological materials, can solve the problems of complex operation and high requirements, and achieve the effects of good biocompatibility, stable quality, and no toxic and side effects

Active Publication Date: 2021-10-15
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it first needs to use high temperature pyrolysis method to prepare NaGdF 4 :20%Yb / 1%Er(UCNPs), and then prepare UCNPs by continuous coating method, and then synthesize UCNPs@SiO with core-shell structure 2 Nanomaterials, resynthesized Au 25 , and finally with UCNPs@SiO 2 Nanoparticle-modified Au 25 , the whole process is complicated to operate and requires high conditions

Method used

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  • Upconversion nanocomposite material, preparation method and application for dual dynamic synergistic therapy
  • Upconversion nanocomposite material, preparation method and application for dual dynamic synergistic therapy
  • Upconversion nanocomposite material, preparation method and application for dual dynamic synergistic therapy

Examples

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Embodiment 1

[0042] See attached Figure 1-7 , a kind of up-conversion nanocomposite material for the integration of dual dynamic therapy and diagnosis and treatment provided in this embodiment, it adopts lateral growth and covalent connection method, and two kinds of therapeutic reagents (C 3 N 4 , MnO 2 ) is connected to the surface of the up-conversion nanocrystal, and the up-conversion nanocrystal is NaYF 4 :Yb,Tm@NaGdF 4 . The compound dual kinetic therapy reagent (C 3 N 4 , MnO 2 ) preparation of rare earth thulium-doped up-conversion luminescent nanomaterials, which comprises the following steps:

[0043] (1) Disperse 20 mg of NaYF in cyclohexane 4 :Yb,Tm@NaGdF 4 Up-conversion luminescence nanomaterials, 20mL cyclohexane, 14mL tert-butanol, 2mL water and 1M K 2 CO 3 The aqueous solution was added into a two-necked flask, stirred at room temperature for 20min, and then 4mL of Lemieux-von Rudloff reagent (5.7mM KMnO 4 and 0.105M NaIO 4 aqueous solution) was added dropwise...

Embodiment 2

[0053] This example provides an upconversion nanocomposite material for dual dynamic therapy, its preparation method and application. Specifically, the method of side growth and covalent connection is used to compound the dual dynamic therapy reagent (C 3 N 4 , MnO 2 ) rare earth erbium, thulium co-doped up-conversion luminescent nanomaterial, which is basically the same as in Example 1, except that it comprises the following steps:

[0054] (1) Disperse 25 mg of NaYF in cyclohexane 4 :Yb,Tm,Er@NaGdF 4 Up-converting luminescence nanomaterials, 20mL cyclohexane, 14mL tert-butanol, 2mL water and 1M K 2 CO 3 The aqueous solution was added into the two-necked flask, stirred at room temperature for 30min, and then 5mL of Lemieux-von Rudloff reagent (5.7mM KMnO 4 and 0.105M NaIO 4 aqueous solution) was added dropwise to the solution, and the resulting mixture was stirred at 45 °C for 40 hours, centrifuged, and the product was collected and washed several times with deionized w...

Embodiment 3

[0060] This example provides an upconversion nanocomposite material for dual dynamic therapy, its preparation method and application. Specifically, the method of side growth and covalent connection is used to compound the dual dynamic therapy reagent (C 3 N 4 , MnO 2 ) rare earth holmium and thulium co-doped up-conversion luminescent nanomaterials, which are basically the same as those in Examples 1 and 2, except that they include the following steps:

[0061] (1) Disperse 22 mg of NaYF in cyclohexane 4 :Yb,Tm,Ho@NaGdF 4 Up-converting luminescence nanomaterials, 20mL cyclohexane, 14mL tert-butanol, 2mL water and 1M K 2 CO 3 The aqueous solution was added into the two-necked flask, stirred at room temperature for 35min, and then 5mL of Lemieux-von Rudloff reagent (5.7mM KMnO 4 and 0.105M NaIO 4 aqueous solution) was added dropwise to the solution, and the resulting mixture was stirred at 45 °C for 40 hours, centrifuged, and the product was collected and washed several tim...

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Abstract

The invention discloses a preparation method for upconversion nanocomposite materials for dual-dynamic synergistic therapy, which comprises the following steps: (1) the synthesis surface is coated with inert NaGdF 4 layer of oil-soluble rare earth up-conversion luminescent nanocrystals to obtain azelaic acid-capped hydrophilic up-conversion nanoparticles to form the first dispersion; (2) KMnO 4 Add the first dispersion until a brown colloid is formed to form the second dispersion; (3) prepare the hydrophilic polymer ligand and stir with the second dispersion to obtain the third dispersion; (4) prepare the C 3 N 4 , under the action of an activating agent, carry out carboxylamine activated coupling with the third dispersion liquid, that is, to obtain side-grown MnO 2 and covalently attach C 3 N 4 upconversion nanocomposites. The invention also discloses its prepared material and application. The material also has multiple application values ​​such as synergistic dual-dynamic therapy, up / down conversion fluorescence imaging, and magnetic resonance imaging, and has potential application prospects in biomedical fields such as tumor diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to an up-conversion nano-composite material used for dual-power synergistic therapy and its preparation method and application. Background technique [0002] In recent years, cancer has become one of the major diseases that endanger human health. As one of the main methods of cancer diagnosis, bioimaging has gradually become a research hotspot. Compared with other imaging techniques, bio-optical imaging has the advantages of simple operation, intuitive and easy to accept, relatively low signal strength and low cost, and has broad prospects in the diagnosis and treatment of various diseases. Among them, rare earth up-conversion luminescent nanomaterials have attracted widespread attention due to their unique luminescent properties. This is because it can be excited by near-infrared light and emit ultraviolet, visible and near-infrared light, which is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/00A61K47/52A61K49/00A61K49/08A61P35/00
CPCA61K33/00A61K41/0057A61K49/0002A61K49/0019A61K49/0069A61K49/08A61K47/52A61P35/00A61K2300/00
Inventor 方建慧汪姝含孙丽宁陶勤峰
Owner SHANGHAI UNIV