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Care solution for rigid gas permeable contact lenses and preparation method of care solution.

A technology of corneal contact lens and care solution, applied in the field of care solution, which can solve the problems of lens silicide damage, impact on lens life, lens deformation, etc., and achieve the effects of preventing inflammation, reducing friction and increasing lubrication

Active Publication Date: 2020-02-21
SHAANXI RENKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 3. The main component of RGP is silicon-based fluoride. Long-term immersion in traditional care solutions will cause lens deformation. The main reason is that some bactericidal compounds react chemically with lens silicide, resulting in damage to lens silicide and affecting the life of the lens.

Method used

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  • Care solution for rigid gas permeable contact lenses and preparation method of care solution.
  • Care solution for rigid gas permeable contact lenses and preparation method of care solution.
  • Care solution for rigid gas permeable contact lenses and preparation method of care solution.

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Experimental program
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Effect test

Embodiment 1

[0027] The preparation material ratio of the silica nano-sol of the present embodiment is as follows: 1.5 parts of ammoniacal liquor; 20 parts of ethyl orthosilicate; 0.5 part of fluorosurfactant; 78 parts of ethanol; 3 parts of propylene glycol, 6 parts of glycerol; Divide the ethanol into two even parts, mix them with tetraethyl orthosilicate and ammonia water respectively, and after magnetic stirring for 10 min, gradually drop the alcohol solution of ammonia water into the alcohol solution of tetraethyl orthosilicate, and stir while dripping (5 min). Raise the temperature to 60°C and use an ultrasonic oscillator with a power of 1200W and a frequency of 60KHz. During the oscillation process, propylene glycol and glycerol are slowly added dropwise. After ultrasonic oscillation for 20 minutes, stir for 2 hours. After adding the fluorosurfactant into the reaction system, it is fully stirred and mixed evenly to obtain the silicon dioxide nano sol. Pour low-pressure pure inert ga...

Embodiment 2

[0032] The preparation material ratio of silica nano sol is as follows: 1 part of ammonia water, 20.9 parts of tetraethyl orthosilicate, 0.1 part of fluorosurfactant, 78 parts of ethanol, 4 parts of propylene glycol, and 5 parts of glycerol;

[0033] Divide the ethanol into two even parts, mix them with tetraethyl orthosilicate and ammonia water respectively, and after magnetic stirring for 10 minutes, gradually drop the alcohol solution of ammonia water into the alcohol solution of tetraethyl orthosilicate, and stir while dripping (5min) . Raise the temperature to 60°C and use an ultrasonic oscillator with a power of 1200W and a frequency of 60KHz. During the oscillation process, propylene glycol and glycerol are slowly added dropwise. After ultrasonic oscillation for 20 minutes, stir for 2 hours. After adding fluorosurfactant to the reaction system, stir and mix well to obtain silica nano-sol; pour low-pressure pure inert gas into the high-vacuum chamber, place sodium chlori...

Embodiment 3

[0039] The preparation material ratio of silica nano sol is as follows: 1.8% ammonia water; 22% tetraethyl orthosilicate; 0.09% fluorosurfactant; 77.73% ethanol; 7 parts of propylene glycol, 4 parts of glycerol;

[0040] Divide the ethanol into two even parts, mix them with tetraethyl orthosilicate and ammonia water respectively, and after magnetic stirring for 10 minutes, gradually drop the alcohol solution of ammonia water into the alcohol solution of tetraethyl orthosilicate, and stir while dripping (5min) . Raise the temperature to 60°C and use an ultrasonic oscillator with a power of 1200W and a frequency of 60KHz. During the oscillation process, propylene glycol and glycerol are slowly added dropwise. After ultrasonic oscillation for 20 minutes, stir for 2 hours. After adding fluorosurfactant to the reaction system, stir and mix well to obtain silica nano-sol; pour low-pressure pure inert gas into the high-vacuum chamber, place sodium chloride particles in a high-tempera...

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Abstract

The invention discloses a care solution for rigid gas permeable contact lenses and a preparation method of the care solution. The care solution includes lifitegrast, polyaminopropyl biguanide, disodium edetate, poloxamer, polyoxyethylene hydrogenated castor oil, 1-hydroxyethylidene-1,1-diphosphonicacid, hydroxypropyl-beta-cyclodextrin, hydroxypropyl methylcellulose, propylene glycol, glycerol, mannitol, boric acid, sodium chloride and tris(hydroxymethyl)aminomethane, and can successfully treat proteins and bacteria adhered to the lenses, and achieve the effect of cleaning the lenses and residual proteins; the care solution blocks connection of ICAM-1, prevent corneal cells from proliferating to cause inflammation, has good lubricity to reduce the discomfort of wearers in the early stage, and has a good oxygen transmission rate.

Description

technical field [0001] The invention belongs to the technical field of nursing solutions, and in particular relates to a rigid contact lens nursing solution and a preparation method thereof. Background technique [0002] Rigid Gas Permeable Contact Lens, or RGP, is called "breathing contact lens", and its composition is mainly silicon-based fluoride, among which silicon, fluorine and other polymers can greatly increase the Oxygen passage, reducing the wearer's eye inflammation and discomfort, making it popular all over the world. And as its supporting nursing solution, its main problem is as follows: [0003] 1. Since the wearing of RGP is different from that of soft lenses, it does not need to be taken off and cleaned every day, so it is very easy to produce corneal cell aggregation and hyperplasia during the wearing process. The proliferation of cells will not only reduce the oxygen flow rate of RGP, but also cause corneal inflammation, causing discomfort to the wearer. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/00C11D3/04C11D3/16C11D3/20C11D3/22C11D3/30C11D3/33C11D3/34C11D3/36C11D3/48C11D3/60
CPCC11D1/00C11D1/004C11D1/50C11D1/722C11D1/74C11D3/0078C11D3/042C11D3/046C11D3/162C11D3/2044C11D3/2065C11D3/225C11D3/30C11D3/33C11D3/349C11D3/361C11D3/48
Inventor 龙雨
Owner SHAANXI RENKANG PHARMA
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