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Preparation method of multifunctional intravascular stent

A vascular stent and a multifunctional technology, which is applied in the field of preparation of multifunctional vascular stents, can solve the problems of inflammatory reaction and poor biocompatibility, and achieve the effects of good antibacterial performance, fast deposition speed and excellent anticoagulant performance.

Active Publication Date: 2020-02-25
成都迈德克科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the rapamycin drug-eluting stents in clinical use mainly use polymers as carriers, which have poor biocompatibility and will cause a certain degree of inflammatory response, leading to clinical complications

Method used

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  • Preparation method of multifunctional intravascular stent
  • Preparation method of multifunctional intravascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Multifunctional Vascular Stents

[0024] (1) Preparation of dopamine-coated stent

[0025] The vascular stent was ultrasonically cleaned with acetone, ethanol and distilled water for 10 minutes in sequence, and after drying, it was immersed in a 0.2 mg / ml dopamine solution with a pH of 8.0-8.5. After reacting at room temperature for 24 hours, it was fully cleaned and dried to obtain polydopamine-coated Stent.

[0026] (2) Preparation of chitosan-functionalized graphene oxide

[0027] Ultrasonic disperse graphene oxide and chitosan in MES buffer solution with pH=5~6 respectively to obtain 1mg / ml dispersion liquid respectively, take 5ml of graphene oxide and chitosan solution and mix thoroughly, add 1ml respectively 5mM of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide solution, shaking reaction for 4 hours, repeated centrifugation and water washing to remove unreacted substances, to obtain shell Functionalization of Glycans in Gr...

Embodiment 2

[0033] Preparation of Multifunctional Vascular Stents

[0034] (1) Preparation of dopamine-coated stent

[0035] The vascular stent was ultrasonically cleaned with acetone, ethanol and distilled water for 10 minutes in sequence, and after drying, it was immersed in a 0.5 mg / ml dopamine solution with a pH of 8.0-8.5. After reacting at room temperature for 24 hours, it was fully cleaned and dried to obtain polydopamine-coated Stent.

[0036] (2) Preparation of chitosan-functionalized graphene oxide

[0037] Ultrasonic disperse graphene oxide and chitosan in MES buffer solution with pH=5~6 respectively to obtain 3mg / ml dispersion liquid respectively, take 5ml of graphene oxide and chitosan solution and mix thoroughly, add 1ml respectively 5mM of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide solution, shaking reaction for 4 hours, repeated centrifugation and water washing to remove unreacted substances, to obtain shell Functionalization of Glycans in Gr...

Embodiment 3

[0043] Preparation of Multifunctional Vascular Stents

[0044] (1) Preparation of dopamine-coated stent

[0045] The stent was ultrasonically cleaned with acetone, ethanol and distilled water for 10 minutes, dried and then immersed in a 1 mg / ml dopamine solution with a pH of 8.0-8.5, reacted at room temperature for 24 hours and then fully cleaned and dried to obtain a polydopamine-coated blood vessel stand.

[0046] (2) Preparation of chitosan-functionalized graphene oxide

[0047] Ultrasonic disperse graphene oxide and chitosan respectively in MES buffer solution with pH=5~6 to obtain 5mg / ml dispersion respectively, take 5ml of graphene oxide and chitosan solution and mix thoroughly, add 1ml respectively 10mM 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide solution, shaking reaction for 4 hours, repeated centrifugation and water washing to remove unreacted substances, to obtain shell Functionalization of Glycans in Graphene Oxide.

[0048] (3) Prepa...

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Abstract

The invention discloses a preparation method of a multifunctional intravascular stent. The preparation method comprises the following steps: firstly, preparing a dopamine coating on the surface of theintravascular stent through dopamine autopolymerization; then loading heparin into the chitosan functionalized graphene oxide, and further fixing the heparin-loaded graphene oxide on the surface of the intravascular stent with the dopamine coating to obtain the heparin-loaded intravascular stent; finally, immersing the intravascular stent in a rapamycin solution to fully adsorb and load rapamycin, and obtaining the multifunctional intravascular stent. Due to the antibacterial effect and the endothelial cell growth promoting effect of chitosan, the anticoagulation effect and the selective endothelial cell growth promoting effect of heparin and the anti-hyperplasia effect of rapamycin, the intravascular stent prepared through the method can inhibit clinical complications of stent implantation from multiple ways, and therefore the application effect of the intravascular stent is improved.

Description

technical field [0001] The present invention designs the field of medical devices and biological materials, and specifically relates to a method for preparing a multifunctional vascular stent. The method is used to prepare a vascular stent, and at the same time endows the stent with good antibacterial performance, anticoagulation performance, anti-proliferation performance and endothelial growth-promoting performance. , improve the clinical application effect of the stent. Background technique [0002] Cardiovascular diseases such as coronary heart disease are a serious threat to human life and health. As the main method for the treatment of coronary heart disease, vascular stent interventional therapy has the advantages of low operation cost, small trauma, and rapid postoperative recovery. However, due to the poor self-biocompatibility of the polymer coating in the traditional stent system and the delay in vascular endothelial healing caused by anti-proliferative drugs, the...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/16
CPCA61L31/084A61L31/10A61L31/16A61L2300/216A61L2300/232A61L2300/416A61L2300/45C08L79/02C08L5/10
Inventor 潘长江刘恒全刘涛龚韬
Owner 成都迈德克科技有限公司
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