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Efficient low-toxicity pollution-free broad-spectrum bactericidal new copper compound and composition thereof

A high-efficiency, low-toxicity, compound technology, applied in the field of pesticides, can solve the problems of uncontrolled or lax control of impurity content, impact on environmental and ecological safety, and reduce the stability of active ingredients, so as to achieve good availability and improve operability Sexuality and the effect of reducing operating costs

Pending Publication Date: 2020-03-03
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] 2. Most of the original drug products do not control or control the impurity content strictly
The high content of impurities in technical products may lead to adverse effects in many aspects. For example, some impurities have high toxicity, some will bring difficulties to the preparation processing, and some will reduce the stability of active ingredients.
With the use of preparation products, these impurities may also affect the environment and ecological safety, and even cause large-scale crop phytotoxicity.
[0015] So far, there is no published literature at home and abroad to report the novel thiabactin copper compound of the present invention with better stability, such as thiabactin copper v-type crystalline compound, i.e. new thiabactin copper crystalline hydrate with different molecular formulas and its preparation method and use

Method used

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  • Efficient low-toxicity pollution-free broad-spectrum bactericidal new copper compound and composition thereof
  • Efficient low-toxicity pollution-free broad-spectrum bactericidal new copper compound and composition thereof
  • Efficient low-toxicity pollution-free broad-spectrum bactericidal new copper compound and composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] The preparation of embodiment 1 thiazole copper 0.5 hydrate (v type compound)

[0170] At room temperature, add 7.991g of 2-amino-5-mercapto-1,3,4-thiadiazole to a 500ml flask, add 30ml of water, stir, add 30ml of an aqueous solution of 2.45g of sodium hydroxide, stir to dissolve, and then Add 60ml of an aqueous solution of 7.491g of copper sulfate pentahydrate, add a small amount of water into the flask, stir at 40°C for 20 minutes, then place it at room temperature for half an hour, filter with suction, wash the solid with a small amount of water to make the filtrate free of sulfate ions, and filter with suction to obtain The solid was diluted and air-dried at about 50°C for about 5 hours to obtain 9.66g of a yellow-green solid; HPLC: the retention time of the main peak of HPLC was consistent with the retention time of the main peak of HPLC of thiazole copper anhydrate; Analysis: The weight loss of the platform is about 2.83% (see attached figure 1 ), has a correspo...

Embodiment 2

[0171] Preparation of embodiment 2 thiazole copper 0.5 hydrate (v type compound)

[0172] At room temperature, add 7.991g of 2-amino-5-mercapto-1,3,4-thiadiazole to a 250ml flask, add 30ml of water, stir, add 30ml of an aqueous solution of 2.5g of sodium hydroxide, stir to dissolve, and then Add 70ml of an aqueous solution of 7.491g of copper sulfate pentahydrate, add a small amount of water into the flask, stir at 35°C for 20 minutes, then place it at room temperature for 20 minutes, filter with suction, wash the solid with a small amount of water to make the filtrate free of sulfate ions, wash once with a small amount of ethanol , filtered with suction, and the obtained solid was diluted and air-dried at about 45°C for 1 hour, and then dried at about 50°C for about 5 hours to obtain 9.6 g of a yellow-green solid; HPLC: the retention time of the main peak of the HPLC is consistent with the retention time of the main peak of the HPLC of thiazole copper Moisture measured by Kar...

Embodiment 3

[0173] The preparation of embodiment 3 Thiobacterium copper 0.5 hydrate

[0174] At room temperature, add 7.991 g of 2-amino-5-mercapto-1,3,4-thiadiazole and 30 ml of water into a 250 ml flask, stir, and add dropwise an aqueous solution of 3.46 g of potassium hydroxide (dissolved in 40 ml of water), Stir for 30 minutes, then add 50ml of an aqueous solution of 5.12g of copper chloride dihydrate, add a small amount of water to wash the container into the flask, stir at about 30°C for half an hour, leave it at room temperature for half an hour, filter with suction, wash the solid with a small amount of water to make the filtrate free of sulfuric acid root ion, washed once with a small amount of methanol, and filtered with suction. The obtained solid was diluted and air-dried at about 45°C for 1 hour, and then dried at about 50°C for about 5 hours to obtain 9.6g of yellow-green solid; HPLC: the retention time of the main peak of HPLC is the same as that of thiazole The main peak r...

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Abstract

The invention relates to an efficient low-toxicity pollution-free broad-spectrum bactericidal new copper compound, which is a thiodiazole-copper v-type compound. According to the invention, the preparation method has advantages of low energy consumption, easy preparation, environmental protection, low hygroscopicity of product, good storage stability of product and like; the compound and the composition thereof are suitable for preparing pesticides for preventing and treating various bacterial and fungal diseases on crops and / or promoting crop health or growth and development or agents for protecting industrial materials from being invaded by pathogenic bacteria.

Description

technical field [0001] The invention relates to the technical field of pesticides, in particular to provide a new compound with high efficiency, low toxicity, safety, pollution-free and better stability of the broad-spectrum bactericidal drug thibacterium copper, its composition and its preparation method and application. Background technique [0002] Thiobacterium copper, the chemical name is bis(2-amino-5-mercapto-1,3,4-thiadiazole) copper, the molecular weight is 327.93, and the trade name is "Longke bacteria"; it can be used in the field of fine chemicals, including materials science, etc. On the one hand, it is also an organocopper broad-spectrum fungicide developed and synthesized by Zhejiang Longwan Chemical Co., Ltd. The drug has multiple functions such as systemic absorption, conduction, prevention, protection, and treatment, and its therapeutic effect is greater than its protective effect. A new generation of high-efficiency, low-toxicity, safe, and broad-spectrum ...

Claims

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Application Information

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IPC IPC(8): C07D285/135A01N43/824A01N59/20A01N43/653A01N43/78A01N47/24A01N55/10A01N43/16A01N37/46A01N37/24A01N43/56A01N43/90A01N47/12A01N47/18A01N43/80A01N43/84A01N37/34A01N37/50A01N43/88A01N43/36A01P1/00A01P3/00
CPCC07D285/135A01N43/82A01N59/20A01N43/653A01N43/78A01N47/24A01N55/00A01N43/16A01N37/46A01N37/24A01N43/56A01N43/90A01N47/12A01N47/18A01N43/80A01N43/84A01N37/34A01N37/50A01N43/88A01N43/36
Inventor 刘力
Owner 刘力
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