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Supramolecular polymer hydrogel with injectability and rapid recovery performance, preparation method and applications thereof

A supramolecular polymer, rapid recovery technology, used in pharmaceutical formulations, drug delivery, medical science and other directions, can solve the problems that limit the wide application of vitreous surgery, not ideal, and prone to emulsification.

Active Publication Date: 2020-03-03
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, silicone oil is widely used clinically as a filling material after vitrectomy, but it is not ideal as a vitreous replacement material
Silicone oil is prone to emulsification, cataract and other eye problems after long-term storage in the eye, which limits the wide application of vitreous surgery to a certain extent

Method used

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  • Supramolecular polymer hydrogel with injectability and rapid recovery performance, preparation method and applications thereof
  • Supramolecular polymer hydrogel with injectability and rapid recovery performance, preparation method and applications thereof
  • Supramolecular polymer hydrogel with injectability and rapid recovery performance, preparation method and applications thereof

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Embodiment Construction

[0021] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0022] In the embodiment, poly(acryloyl glycinamide-co-acrylamide carboxylate betaine) (PNAGA-PCBAA) hydrogels with different monomer concentrations were synthesized, and PNAGA-PCBAA-10-4 (acryloyl glycinamide Aminoamide monomer and acrylamidocarboxybetaine monomer and initiator account for 10% of the total mass ratio of the two monomers, initiator and water, and acryloyl glycinamide monomer and acrylamidocarboxybetaine The mass ratio of alkali monomer is 4:1) as an example. After completely dissolving acryloyl glycinamide (NAGA) (104 mg) in 1224 μL of deionized water, add acrylamidocarboxybetaine (26 mg) and photoinitiator Irgacure 1173 (2-hydroxy-2-methyl-1- phenyl-1-propanone) 6 μL. After the mixed solution is filled with nitrogen to remove oxygen, the mixed solution is injected into a closed mold, and the mold is irradiated in a UV curing bo...

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Abstract

The invention discloses a supramolecular polymer hydrogel with injectability and rapid recovery performance, a preparation method and applications thereof, wherein the poly(acryloyl glycine amide-co-acryloyl amino carboxylic acid betaine) supramolecular polymer hydrogel is prepared by taking acryloyl glycine amide and acryloyl amino carboxylic acid betaine as raw materials through free radical polymerization in the presence of an initiator. According to the invention, the mechanical property of the hydrogel is adjusted by changing the concentration of the initial monomer, so that the hydrogelcan achieve the purposes of room-temperature injection and rapid recovery while the self-repairing function can be achieved at a low temperature, the hydrogel has good biocompatibility, and the preparation methods of the monomer and the hydrogel are simple and easy to implement; and the hydrogel is expected to be used as a vitreous body substitute.

Description

technical field [0001] The present invention relates to a kind of hydrogel and preparation method, relate to a kind of PNAGA-PCBAA hydrogel prepared by using acryloyl glycinamide (NAGA) and acrylamidocarboxybetaine (CBAA) as monomers The preparation method and performance research of the gel, the hydrogel has multiple functions such as rapid recovery, self-healing, anti-inflammation and anti-fibrosis, and is expected to be used as a vitreous replacement material. Background technique [0002] The vitreous body is a colorless and transparent jelly that fills the space between the lens and the retina. It is mainly composed of hyaluronic acid and collagen fibers. Most of the components are water. It has the functions of refraction and fixation of the retina, and has no regeneration ability. , With the increase of age, when the tissues around the vitreous body become lesions, the vitreous body will also be affected and undergo liquefaction, degeneration and turbidity. At presen...

Claims

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Application Information

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IPC IPC(8): C08F220/60C08F2/48A61L27/16A61L27/50A61L27/52
CPCA61L27/16A61L27/50A61L27/52A61L2400/06A61L2430/16C08F2/48C08F220/60C08L33/26
Inventor 刘文广王宏博
Owner TIANJIN UNIV
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