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A kind of glucosamine heparin salt and application thereof

A technology of glucosamine and heparin salt, applied in the field of glucosamine heparin salt, can solve problems such as thrombocytopenia, and achieve the effect of broad application prospect and enhanced anticoagulant effect

Active Publication Date: 2022-02-01
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Heparin is a clinical drug with a wide range of uses. It has been used clinically as an anticoagulant and antithrombotic drug for more than 60 years, but long-term use can lead to adverse phenomena such as bleeding and thrombocytopenia.

Method used

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  • A kind of glucosamine heparin salt and application thereof
  • A kind of glucosamine heparin salt and application thereof
  • A kind of glucosamine heparin salt and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 5 g of heparin with a molecular weight of 80,000 (see figure 2 ) with 1g glucosamine hydrochloride (see figure 1 ), dissolved in water, dialyzed for 2 days in a dialysis bag with a molecular weight cut-off of 500Da, concentrated by rotary evaporation, and freeze-dried to obtain glucosamine heparin salt (see image 3 ).

Embodiment 2

[0031] The difference from Example 1 is:

[0032] Weigh 2 g of heparin with a molecular weight of 10,000 and 3 g of glucosamine hydrochloride, dissolve them in water, dialyze in a dialysis bag with a molecular weight cut-off of 200 Da for 3 days, concentrate by rotary evaporation, precipitate with ethanol, filter with suction, and dry at 60 degrees Celsius for 8 hours , to obtain glucosamine heparin salt (see image 3 ).

Embodiment 3

[0034] The difference from Example 1 is:

[0035] Weigh 3g of heparin with a molecular weight of 2000 and 2g of glucosamine hydrochloride, dissolve them in water, use ion exchange, remove metal ions through a cation exchanger, and then enter an anion exchanger to remove anions to obtain a glucosamine heparin salt solution, spray Dried to obtain glucosamine heparin salt (see image 3 ).

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Abstract

The invention relates to functional food and pharmaceutical industries, in particular to a glucosamine heparin salt and its application. The structural formula of glucosamine heparin salt is shown in formula (1), wherein the average degree of polymerization n ranges from 5-500. The glucosamine heparin salt is obtained from glucosamine hydrochloride or sulfate or phosphate and heparin sodium through ion exchange, or dialysis of a mixed solution, or direct precipitation of a mixed solution, wherein the molecular weight of the heparin used is naturally extracted or prepared by fermentation , or degradation obtained, or all polysaccharides that conform to the heparin structure obtained through synthetic methods. The invention combines heparin and glucosamine organically, which is different from the existing compound products of the two, and has higher purity, and the prepared glucosamine heparin salt has stronger anticoagulant effect, and can be used for but not limited to anticoagulant The use of blood medicine therapy or auxiliary health care effect. Glucosamine heparin salt can be widely used in the fields of functional food and medicine.

Description

technical field [0001] The invention relates to functional food and pharmaceutical industries, in particular to a glucosamine heparin salt and an application thereof. Background technique [0002] Glucosamine compounds are a class of specific drugs for the treatment of osteoarthritis, and are also important components necessary for the synthesis of amino polysaccharides in the human articular cartilage matrix. At present, the reported glucosamine compounds are almost all in the form of glucosamine inorganic acid salts, mainly including its hydrochloride, sulfate, and compound salts containing metal elements such as magnesium and calcium. Among them, glucosamine hydrochloride is mainly obtained by degrading chitin under hydrochloric acid and high temperature conditions; the preparation of glucosamine sulfate is obtained by degrading chitin through sulfuric acid, and one method is through glucosamine hydrochloride obtained by salt substitution. The preparation of various glu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10A61K31/7028A61P7/02A23L33/00
CPCC08B37/0075A61K31/7028A61P7/02A23L33/00A23V2002/00A23V2200/30
Inventor 郭占勇谭文强王刚董方李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI