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Acetylsalicylic acid slow release capsules and preparation method thereof

A technology of aspirin and sustained-release capsules, which is applied in the field of medicine, can solve the problems of slow dissolution and achieve the effect of increasing early drug release, rapid treatment and prevention of diseases

Inactive Publication Date: 2020-03-20
沈阳东星医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results prove that the tablets prepared by the sustained-release formulation in this test all have sustained-release effect, and the sustained-release effect of EC is stronger than that of HPMC, and the sustained-release effect of HPMC and EC mixed matrix materials is the strongest, but there is a problem of too slow dissolution
But there is no report on the preparation of aspirin sustained-release capsules by the sustained-release layer coating technology

Method used

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  • Acetylsalicylic acid slow release capsules and preparation method thereof
  • Acetylsalicylic acid slow release capsules and preparation method thereof
  • Acetylsalicylic acid slow release capsules and preparation method thereof

Examples

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Comparison scheme
Effect test

preparation example Construction

[0063] The invention provides the preparation method of described aspirin sustained-release capsules, comprising the following steps:

[0064] 1) dispersing the components of the isolation layer in an organic solvent to obtain a coating solution for the isolation layer;

[0065] 2) Coating the aspirin crystals in the isolation layer coating liquid with an isolation layer and solidifying them to obtain aspirin crystals coated with an isolation coat;

[0066] 3) dispersing the components of the sustained-release layer in the organic solvent to obtain a coating solution for the sustained-release layer;

[0067] 4) The aspirin crystals of step 2) with isolation coat or the aspirin crystals without isolation coat are coated with slow-release layer in the slow-release layer coating liquid, and solidified to obtain the aspirin with isolation coat and slow-release coat Sustained-release granules or aspirin sustained-release granules with sustained-release coating only;

[0068] The ...

Embodiment 1

[0080] Embodiment 1: preparation of aspirin sustained-release capsules

[0081] 1. Preparation of aspirin crystals with isolation coat:

[0082] (1) Prescription of the coating solution for the isolation layer (according to 1000 capsules)

[0083]

[0084]

[0085] (2) Preparation process of coating solution for isolation layer

[0086] Add the prescription amount of PVPK30, castor oil, tartaric acid, and talc to absolute ethanol, stir and disperse evenly, and pass the coating solution through an 80-mesh sieve before coating.

[0087] (3) Preparation process of aspirin crystals with isolation coat

[0088] The DPL-II multifunctional granulating and pellet coating machine (Chongqing Seiko) was used for coating until the coating solution was finished, and samples within the range of 20-60 mesh were collected for slow-release layer coating. The operating parameters are: fan frequency: 19HZ; air inlet temperature: 35°C; liquid supply speed: 7-8rpm; material temperature: 3...

Embodiment 2

[0105] Embodiment 2: preparation of aspirin sustained-release capsules

[0106] 1. Preparation of aspirin crystals with isolation coat:

[0107] (2) Prescription of the coating solution for the isolation layer (according to 1000 capsules)

[0108]

[0109] (2) Preparation process of coating solution for isolation layer

[0110] Add the prescription amount of PVPK30, castor oil, tartaric acid, and talc to absolute ethanol, stir and disperse evenly, and pass the coating solution through an 80-mesh sieve before coating.

[0111] (3) Preparation process of aspirin crystals with isolation coat

[0112] The DPL-II multifunctional granulating and pellet coating machine (Chongqing Seiko) was used for coating until the coating solution was finished, and the samples within the range of 20 to 60 mesh were collected for slow-release layer coating. The operating parameters are: fan frequency: 19HZ; air inlet temperature: 35°C; liquid supply speed: 7-8rpm; material temperature: 30°C; ...

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Abstract

The invention provides acetylsalicylic acid slow release capsules and a preparation method thereof, and belongs to the technical field of medicines. The contents of the acetylsalicylic acid slow release capsules comprise acetylsalicylic acid slow release granules which are sequentially acetylsalicylic acid crystals, an isolating layer and a slow release layer from the inner part to the outer part,acetylsalicylic acid slow release granules which are sequentially acetylsalicylic acid crystals and the slow release layer from the inner part to the outer part, and a mixture thereof. A preparationmethod of the granules is realized through a fluidization bed coating technique and comprises the steps of coating the acetylsalicylic acid crystals with an isolating layer; preparing the granules forthe coating of the slow release layer for the acetylsalicylic acid crystals coated with the isolation coating; or directly preparing the slow release granules for the coating the slow release layer for the acetylsalicylic acid crystals. The release behavior lies in that the medicine release dosage within 30min is small than 10%, the drug release dosage is 45%-55% and the drug release dosage within 24h is 70% or above. The obtained acetylsalicylic acid slow release capsules have high repeatability, good stability and obvious slow release effects. The acetylsalicylic acid slow release capsuleshave the characteristics of being stable and durable in blood drug level, low in side effects, high in compliance and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an aspirin sustained-release capsule and a preparation method thereof. Background technique [0002] In 1897, German chemist Dr. Felix Hoffmann synthesized acetylsalicylic acid for the first time, leading to the classic legend of aspirin. As a drug, aspirin can reduce inflammation when taken in large doses, relieve pain when taken in medium doses, and prevent blood vessel blockage caused by platelet aggregation when taken in small doses. , At the same time, it can effectively prevent cardiovascular diseases caused by thrombus. The structural formula of aspirin is as follows: [0003] [0004] Aspirin (acetylsalicylic acid, ASA) is not only an antipyretic and analgesic drug (for the treatment of colds, fever, infection, rheumatism, etc.), but also a basic drug for stroke prevention. Guidelines for stroke prevention. However, aspirin will be decomposed into salic...

Claims

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Application Information

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IPC IPC(8): A61K9/58A61K31/616A61P29/00A61P9/10A61P7/02
CPCA61K9/5026A61K9/5073A61K9/5084A61K31/616A61P7/02A61P9/10A61P29/00
Inventor 黄浩于叶玲宋籽林尹湉苟靖欣张宇何海冰唐星
Owner 沈阳东星医药科技有限公司
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