Light curing composite for bone tissue engineering and bone tissue engineering bracket based on light curing composite

A technology of bone tissue engineering and composite materials, applied in the field of bone tissue engineering scaffolds and light-cured composite materials, can solve the problems of poor mechanical properties, biocompatibility and degradability of composite materials, serious cross-linking and exothermicity, etc., and achieve excellent mechanical properties. Properties and biological activity, reducing powder agglomeration, avoiding potential toxic effects

Active Publication Date: 2020-03-24
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] For this reason, the first purpose of the embodiment of the present invention is to provide a light-cured composite material for bone tissue engineering to solve the problems of existing composite materials with poor mechanical properties, biocompatibility and degradability, and severe cross-linking heat release. question

Method used

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  • Light curing composite for bone tissue engineering and bone tissue engineering bracket based on light curing composite
  • Light curing composite for bone tissue engineering and bone tissue engineering bracket based on light curing composite
  • Light curing composite for bone tissue engineering and bone tissue engineering bracket based on light curing composite

Examples

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Embodiment 1

[0072] 1. Light-cured composite materials for bone tissue engineering

[0073] The above photocurable composite material for bone tissue engineering is obtained by photopolymerization of polylactide-propylene glycol dimethacrylate and hydroxyapatite, wherein:

[0074] Polylactide-Propylene Glycol Dimethacrylate is P 7 L 2 DMA;

[0075] The content of hydroxyapatite in the composite material is 30%;

[0076] The ultraviolet light intensity used in photopolymerization is 5.5mW / cm 2 .

[0077] 2. Scaffolds for bone tissue engineering based on the above-mentioned composite materials

[0078] The above-mentioned bone tissue engineering scaffold is prepared by the following method:

[0079] (a) Establish the STL file of the three-dimensional model of the composite material, and process the STL file according to the microstructure of the three-dimensional model, and then export the STL file;

[0080] (b) Import the STL file into the 3D printer;

[0081] (c) Mix polylactide-pr...

Embodiment 2

[0083] 1. Light-cured composite materials for bone tissue engineering

[0084] The above photocurable composite material for bone tissue engineering is obtained by photopolymerization of polylactide-propylene glycol dimethacrylate and hydroxyapatite, wherein:

[0085] Polylactide-Propylene Glycol Dimethacrylate is P 7 L 2 DMA;

[0086] The content of hydroxyapatite in the composite material is 50%.

[0087] The ultraviolet light intensity used in photopolymerization is 5.5mW / cm 2 .

[0088] 2. Scaffolds for bone tissue engineering based on the above-mentioned composite materials

[0089] The above-mentioned bone tissue engineering scaffold is prepared by the following method:

[0090] (a) Establish the STL file of the three-dimensional model of the composite material, and process the STL file according to the microstructure of the three-dimensional model, and then export the STL file;

[0091] (b) Import the STL file into the 3D printer;

[0092] (c) Mix polylactide-pr...

Embodiment 3

[0094] 1. Light-cured composite materials for bone tissue engineering

[0095] The above photocurable composite material for bone tissue engineering is obtained by photopolymerization of polylactide-propylene glycol dimethacrylate and hydroxyethyl methacrylate functionalized hydroxyapatite, wherein:

[0096] Polylactide-Propylene Glycol Dimethacrylate is P 7 L 2 DMA;

[0097] The content of hydroxyapatite functionalized with methacrylic acid hydroxyethyl in the composite material is 30%.

[0098] The ultraviolet light intensity used in photopolymerization is 5.5mW / cm 2 .

[0099] 2. Scaffolds for bone tissue engineering based on the above-mentioned composite materials

[0100] The above-mentioned bone tissue engineering scaffold is prepared by the following method:

[0101] (a) Establish the STL file of the three-dimensional model of the composite material, and process the STL file according to the microstructure of the three-dimensional model, and then export the STL fi...

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Abstract

The embodiment of the invention discloses a light curing composite for bone tissue engineering and a bone tissue engineering bracket based on the light curing composite. The composite is prepared by photopolymerization of poly ( lactide-co-propylene glycol-co-lactide ) dimethacrylate and hydroxyapatite. The poly ( lactide-co-propylene glycol-co-lactide ) dimethacrylate has favorable biocompatibility and degradability, can realize rapid photo-crosslinking under the irradiation of ultraviolet rays, and can be obtained by photopolymerization of (lactide-co-propylene glycol-co-lactide ) dimethacrylate and hydroxyapatite. The poly(lactide-co-propylene glycol-co-lactide) dimethacrylate and the hydroxyapatite are subjected to joint photopolymerization, so that the prepared composite has excellentmechanical properties and bioactivity.

Description

technical field [0001] The embodiments of the present invention relate to the technical field of bone tissue engineering, in particular to a light-cured composite material for bone tissue engineering and a bone tissue engineering scaffold based thereon. Background technique [0002] In large bone defects, the human body lacks self-healing ability, and a certain amount of bone graft is needed to repair them. Although autologous bone grafts are clinically recognized and one of the most effective treatments, they are limited by donor site morbidity, immune and inflammatory responses, and risk of disease transmission. To overcome these problems, bone tissue engineering has received extensive attention as an innovative and promising alternative. At present, there are two main types of three-dimensional (3D) bone tissue engineering materials, namely polymers [polycaprolactone (PCL), polylactic acid (PLA), polylactic-glycosylacetic acid (PLGA), collagen, etc.] and ceramics [bioac...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L27/58B33Y70/10B33Y80/00
CPCA61L27/46A61L27/50A61L27/58B33Y70/00B33Y80/00A61L2430/02A61L2400/12C08L67/04
Inventor 赵昕杨雨禾
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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