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Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method of wrinkle-removing microneedle patch

A technology of hyaluronic acid and macromolecules, applied in the field of microneedles, can solve the problem of unsatisfactory anti-wrinkle effect, achieve good anti-wrinkle effect and increase the effect of loading capacity

Active Publication Date: 2020-03-27
广州新济薇娜生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although most of the current microneedles are added with a large proportion of hyaluronic acid and its sodium salt raw materials, most of them are mainly small molecule hyaluronic acid and its sodium salt, and its anti-wrinkle effect is not ideal.

Method used

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  • Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method of wrinkle-removing microneedle patch
  • Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method of wrinkle-removing microneedle patch
  • Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method of wrinkle-removing microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The particle size of macromolecular hyaluronic acid and its sodium salt purchased directly is relatively large. If the particle size is too large, the sodium hyaluronate particles cannot be filled into the micropores of the microneedle mold or the filling amount is small, so it needs to be processed first. After pulverization, it is used to prepare microneedles. The pulverization method and the particle size measurement steps are as follows: Use an ultra-low temperature liquid nitrogen pulverizer to pulverize macromolecular hyaluronic acid and its sodium salt particles. Measurement, the particle size measurement results before and after crushing are as follows figure 1 shown.

Embodiment 2

[0061] Investigate the dissolution of macromolecular hyaluronic acid and its sodium salt particles in water. The specific operation method is: take four watch glasses, marked as 1, 2, 3, and 4 respectively, and weigh a certain amount of macromolecular hyaluronic acid. After the sodium salt particles (its molecular weight is 2000KDa, particle diameter is 0.2um-20um) are placed in the watch glass, add a certain amount of water respectively, so that the percentage of hyaluronic acid sodium salt particles in 1, 2, 3, and 4 The contents are respectively 10%, 5%, 3%, and 2.5%. After standing for 24 hours, observe the dissolution and swelling. The result is as figure 2 As shown, when the percentage content of sodium hyaluronate is 3%, it just swells completely, but has almost no fluidity; when the percentage content of sodium hyaluronate is 2.5%, it can form a solution state with certain fluidity . Therefore, if water is used as the solvent to prepare the needle body solution, the...

Embodiment 3

[0063] This embodiment provides a wrinkle-removing microneedle patch prepared with high-loaded macromolecular hyaluronic acid and / or its sodium salt particles with a mass fraction of 65% ethanol aqueous solution as a solvent for the needle body solution, such as image 3 shown.

[0064] The preparation method of the anti-wrinkle microneedle patch highly loaded with macromolecular hyaluronic acid and / or its sodium salt particles provided in this example comprises the following steps:

[0065] (1) Preparation of needle suspension: take 37 parts of hydrolyzed collagen, 15 parts of tetrahydromethylpyrimidine carboxylic acid, 23 parts of tocopheryl acetate, 23 parts of magnesium ascorbyl phosphate, 1 part of polyethylene glycol 400 and 1 part of 30% triethyl citrate, they are mixed, adding mass fraction is 65% ethanol aqueous solution, after stirring and making it dissolve, obtain the solution that solid content is 5%, continue to add povidone K30 and povidone K90 (mass ratio is 9...

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Abstract

The invention relates to a wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and / or sodium salt particles thereof and a preparation method of the wrinkle-removing microneedle patch. The wrinkle-removing microneedle patch comprises a needle body and a substrate, wherein the needle body is prepared from macromolecular hyaluronic acid and / or sodium salt particles thereof, an ethanol aqueous solution, a small molecular substance and a carrier material, and the substrate is prepared from a degradable material; the molecular weight of the macromolecular hyaluronic acidand / or sodium salt particles thereof is 1500KDa-3000KDa; the small molecular substance consists of hydrolyzed collagen, ectoine, tocopheryl acetate, magnesium ascorbyl phosphate, polyethylene glycoland triethyl citrate; and the carrier material is selected from at least one of glycerin, hydroxy propyl cellulose, povidone and glucan. The wrinkle-removing microneedle patch has high macromolecularhyaluronic acid and / or sodium salt loading capacity and good wrinkle-removing effect.

Description

[0001] field of invention [0002] The invention belongs to the field of microneedles, and in particular relates to a wrinkle-removing microneedle patch highly loaded with macromolecular hyaluronic acid and / or its sodium salt particles and a preparation method thereof. Background technique [0003] The skin is stimulated by the external environment or affected by itself, forming free radicals, which will destroy the collagen and active substances in the normal cell membrane tissue, so that the collagen content in the dermis of the skin gradually decreases, and the water retention decreases. At the same time, the mesh support will also become thicker, harder, and lose its elasticity. When the elasticity and water retention of the dermis decrease, the skin will lose its elasticity and become thinner and aged, and loose wrinkles will form on the epidermis. The common improvement methods for wrinkles include direct injection filling method, polypeptide cytokines to stimulate the s...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/34A61K8/65A61K8/67A61K8/86A61K8/49A61K8/37A61K8/81A61K8/55A61K8/02A61Q19/08A61Q19/00A61M37/00
CPCA61K8/735A61K8/345A61K8/34A61K8/65A61K8/678A61K8/86A61K8/4953A61K8/37A61K8/731A61K8/73A61K8/8176A61K8/55A61K8/0208A61Q19/08A61Q19/00A61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061
Inventor 温新国张敏敏冯家颖陈航平杨思超任春艳
Owner 广州新济薇娜生物科技有限公司
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