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Application method of water-soluble inorganic salt in drug lubrication

A water-soluble inorganic salt, application method technology, applied in the direction of pharmaceutical formulations, inorganic non-active ingredients, medical preparations containing active ingredients, etc., can solve the skin irritation of external drugs, affect the effect and taste of oral drugs, equipment corrosion To solve the problems of mechanical corrosion and taste/skin irritation, high potential economic benefits, and high drug content

Pending Publication Date: 2020-03-31
南京亿华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used drug lubricants mainly include magnesium stearate, talcum powder, etc., and these commonly used drug lubricants are mainly added to drugs through internal addition. However, although these traditional lubricants can improve the sticking phenomenon, they will affect The disintegration speed of the drug, and the oil flower and insoluble matter are produced, which affect the taste, and it is easy to react with acidic components to affect the stability
[0003] Although the document "Chemical Industry Press "Handbook of Pharmaceutical Excipients"" (English: R.C. Luo, P.J. Weller, US: P.J. Sheski) discloses sodium chloride as a lubricant, it is rarely used now because Conventional internal addition of sodium chloride must be added to close to 20-30% to have a good lubricating effect, and at this time has greatly affected the effect and taste of oral drugs, not only corrosive to equipment, but also makes some external use The drug has significant skin irritation

Method used

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  • Application method of water-soluble inorganic salt in drug lubrication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Ingredients: Weigh each raw material according to the prescription amount, as shown in Table 1, and set aside.

[0025] Table 1

[0026] prescription 2.5 million pieces of feed Vitamin C 1270.00kg Lactose (120 mesh) 355.00kg sodium bicarbonate 13000.00kg L-Tartrate 925.00kg aspartame 125.00kg Povidone K30 75.00kg polyethylene glycol 6000 203.50kg β-carotene 12.50kg Orange Juice Powder Flavor 7.50kg Sodium chloride 4.5kg D 4.5kg

[0027] Sodium chloride pretreatment: the sodium chloride is micronized by a jet mill, and its particle size is controlled to 8 μm, for later use.

[0028] Pretreatment of raw and auxiliary materials: crush the prescription amount of L-tartaric acid through an 80-mesh sieve, and pass through an 80-mesh sieve with sodium bicarbonate.

[0029] Preparation of wet granules: Add vitamin C, lactose, sodium bicarbonate, L-tartaric acid, aspartame, polyethylene ...

Embodiment 2

[0038] Ingredients: Weigh each raw material according to the prescription amount, as shown in Table 3, and set aside.

[0039] table 3

[0040] prescription 2.5 million pieces of feed Vitamin C 1270.00kg Lactose (120 mesh) 355.00kg sodium bicarbonate 13000.00kg L-Tartrate 925.00kg aspartame 125.00kg Povidone K30 75.00kg polyethylene glycol 6000 203.50kg β-carotene 12.50kg Orange Juice Powder Flavor 7.50kg potassium chloride 4.5kg D 4.5kg

[0041] Potassium chloride pretreatment: Micronize potassium chloride with a jet mill to control its particle size to 5 μm, and reserve it for later use.

[0042] Pretreatment of raw and auxiliary materials: crush the prescription amount of L-tartaric acid through an 80-mesh sieve, and pass through an 80-mesh sieve with sodium bicarbonate.

[0043] Preparation of wet granules: Add vitamin C, lactose, sodium bicarbonate, L-tartaric acid, aspartame, pol...

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Abstract

The invention discloses an application method of water-soluble inorganic salt in drug lubrication. The application method comprises the following steps: preparing drug semi-finished product particlesaccording to a prescription; tabletting the semi-finished product particles, and in the tabletting process, crushing water-soluble inorganic salt and spraying the crushed water-soluble inorganic saltinto a stamping die device. The invention discloses the application method of the water-soluble inorganic salt in drug lubrication, the understanding that soluble inorganic salt is almost unable to beused as a lubricant in the traditional concept is broken through, through micronization and trace powder spraying technologies, the advantages that soluble inorganic salt crystals are resistant to high temperature, not prone to sticking and high in water solubility, and disintegration is not affected are reserved, and through water-soluble inorganic salt powder spraying lubrication, the disintegration speed of the drug is high, and the drug content is high.

Description

technical field [0001] The invention relates to an application method of a water-soluble inorganic salt in drug lubrication, and belongs to the technical field of drug preparation. Background technique [0002] Drug lubricant is a substance that reduces the friction between the tablet and the wall of the die hole, and is an important indicator that affects the smoothness of the drug surface and the quality of the drug. Commonly used drug lubricants mainly include magnesium stearate, talcum powder, etc., and these commonly used drug lubricants are mainly added to drugs through internal addition. However, although these traditional lubricants can improve the sticking phenomenon, they will affect The disintegration speed of the drug, and the formation of oily flowers and insoluble matter, affect the taste, and it is easy to react with acidic components to affect the stability. [0003] Although the document "Chemical Industry Press "Handbook of Pharmaceutical Excipients"" (Eng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K9/20A61K31/375
CPCA61K47/02A61K9/2009A61K31/375
Inventor 杨鹏辉袁和亮张霞
Owner 南京亿华药业有限公司
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