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A kind of nerve repair catheter and preparation method thereof

A nerve repair and catheter technology, applied in the directions of prosthesis, filament/wire forming, fiber processing, etc., can solve the problems of easy inactivation, no directional spontaneous electrical stimulation, no directional electrical induction, etc., to achieve good biological compatible effects

Active Publication Date: 2021-07-20
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN 103127548 A uses highly oriented fiber membranes composed of different materials to prepare nerve conduits by winding method, but the mechanical properties of the conduits are insufficient, and this method does not have the characteristics of directional electrical induction
Patent CN 102525689 A prepares oriented nanofiber nerve conduits loaded with nerve growth factor, which promotes nerve regeneration by releasing nerve growth factor, but the short half-life of nerve growth factor, easy inactivation, and biological safety limit its practical application. And the invention does not have the stimulating effect of orientation spontaneous electricity
Patent CN 104056306 A uses electrospun polymer fiber as a template, adopts electrochemical pulse polymerization to deposit conductive polymer, coaxially coats conductive polymer on the surface of carbon nanotube bundles, and prepares carbon nanotubes with directional groove structure. Tube / conductive polymer composite coating modified nerve conduit materials, but the conductive polymers used in the preparation of nerve conduits are difficult to degrade and require secondary surgery to remove, causing unnecessary pain to patients

Method used

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  • A kind of nerve repair catheter and preparation method thereof
  • A kind of nerve repair catheter and preparation method thereof
  • A kind of nerve repair catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 of the present invention provides a nerve repair catheter, the nerve repair catheter is a double-layer fiber catheter, and the inner layer is degradable L-alanine-glycolic acid-lactic acid copolymer P (MMD-LA) orientation containing HA nanoparticles The fiber layer, the outer layer is a randomly oriented fiber layer of degradable L-alanine-glycolic acid-lactic acid copolymer. Wherein the molecular weight of the degradable polymer is 150000, and the surface potential of the HA nanoparticles is -6mV~+125mV. The diameter of the catheter lumen is about 1 mm, the thickness of the tube wall is 1 mm, and the thickness ratio of the oriented polymer composite nano-inorganic particle fiber layer and the randomly oriented polymer fiber layer is 1:3.

[0036] figure 1 For the nerve repair conduit that embodiment 1 provides, from figure 1 It can be seen that the nerve repair catheter has a double-layer structure, the inner layer is an oriented nanofiber layer, and the...

Embodiment 2

[0039]Embodiment 2 of the present invention provides a preparation method of a nerve repair catheter, comprising the following steps: providing nano-inorganic particles; adding the degradable polymer and the nano-inorganic particles into an organic solvent according to a certain mass ratio, stirring evenly, and preparing A certain concentration of the first spinning stock solution; under the first electrospinning parameters, the first spinning stock solution is spun into an oriented fiber film by electrospinning to obtain a first fiber layer; a certain amount of degradable The polymer is dissolved in the organic solvent and configured into a second spinning stock solution of a certain concentration; the second spinning stock solution is spun into a randomly oriented fiber film by electrospinning under the second electrospinning parameters, The second fiber layer is obtained; the first film layer and the second film layer are crimped into a double-layer conduit, wherein the crim...

Embodiment 3

[0047] Embodiment 3 of the present invention provides a preparation method of a catheter for nerve repair, which is different from the previous embodiment in that: the polarization conditions of HA are different, and the polymer materials and electrospinning parameters are different.

[0048] Specifically:

[0049] (1) Put HA into an alumina ring with an inner diameter of 1.0 cm and a height of 0.5 cm, and sandwich it between a pair of platinum electrodes. -1 It was polarized in a direct current (DC) electric field for 1 hour, and cooled naturally in air after the polarization was completed to obtain electrically polarized HA.

[0050] (2) Weigh 1 g of L-alanine-glycolic acid copolymer with a molecular weight of 50,000 and 0.01 g of electrically polarized HA, add it to 4 ml of hexafluoroisopropanol, and mix evenly with a magnetic stirrer to obtain a concentration of 25%. (g / ml) of the first spinning dope. Carry out electrospinning to this solution, the process parameters of ...

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Abstract

The invention discloses a nerve repair catheter and a preparation method thereof. The nerve repair catheter is a double-layer fiber catheter, the inner layer of the catheter is a degradable polymer compound electrode polarized nano-inorganic particle oriented fiber layer, and the outer layer is a fiber layer that can A randomly oriented fiber layer of degradable polymer, wherein the orientation direction of the oriented fiber layer is parallel to the axial direction of the catheter. The nerve repair catheter prepared by the present invention has good biocompatibility and is biodegradable, and the inside of the catheter has a directional electrical induction function, which provides physical and electrochemical signals for the directional migration of nerve cells and the growth of axons, and can be used for damaged nerves. Regeneration and docking provide a favorable regenerative microenvironment.

Description

technical field [0001] The invention relates to a nerve repair catheter and a preparation method thereof, belonging to the field of biological materials. Background technique [0002] In my country, about 2 million cases of peripheral nerve injury occur every year. Due to its complex structure and function, peripheral nerve tissue has a high disability rate, poor prognosis and complicated treatment once it is damaged, which has become an important clinical problem. [0003] In the early stage of nerve defect, due to the limited recovery of nerve function, it often leads to skeletal muscle atrophy. Clinically, electrical stimulation is often used to treat the nerves at the injured site. This treatment method can promote the regeneration of peripheral nerves on the one hand, and prevent denervated atrophy of skeletal muscles on the other hand. Patent CN 103127548 A uses highly oriented fiber membranes composed of different materials to prepare nerve conduits by winding metho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/18A61L27/12D01D5/00
CPCA61L27/12A61L27/18A61L27/58A61L2430/32D01D5/0015D01D5/003C08L67/04
Inventor 戴红莲董献振龙燕飘方红琳刘坤
Owner WUHAN UNIV OF TECH