Array chip mass spectrometry analysis method of photoelectrochemical reaction intermediate

An array chip, chemical reaction technology, applied in the field of mass spectrometry analysis, can solve problems such as difficult detection, restricting the development of photoelectric catalysis theory, catalyst development, short life of intermediates, etc., to achieve the effect of in-situ analysis, avoiding delay and avoiding influence

Inactive Publication Date: 2020-04-10
FUDAN UNIV
5 Cites 0 Cited by

AI-Extracted Technical Summary

Problems solved by technology

The development of photoelectrochemistry relies on the development of new catalytic materials. However, because the intermediates of photoelectrochemical reactions usually have short lifespans and are diff...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Abstract

The invention discloses an array chip mass spectrometry analysis method of a photoelectrochemical reaction intermediate. According to the array chip mass spectrometry analysis method, inorganic materials such as titanium dioxide and graphene with semiconductor properties or photocatalytic performance are used for modifying insulating plastics such as glass and polyimide to form a photocatalyst-modified microarray chip; then a substrate for photoelectrochemical reaction is dropwise added on the chip, and a photoelectrochemical reaction is induced by utilizing illumination. After the reaction iscarried out for a period of time, a sample point is detected by utilizing an electrostatic spray ionization mass spectrometry technology, so as to realize photoelectrochemical reaction intermediate analysis.

Application Domain

Technology Topic

Image

  • Array chip mass spectrometry analysis method of photoelectrochemical reaction intermediate
  • Array chip mass spectrometry analysis method of photoelectrochemical reaction intermediate
  • Array chip mass spectrometry analysis method of photoelectrochemical reaction intermediate

Examples

  • Experimental program(2)

Example

[0027] Example 1
[0028] A titanium dioxide-modified array chip is used in conjunction with electrostatic spray ionization mass spectrometry to detect the intermediates in the photooxidation reaction of mitoxantrone. It includes the following steps:
[0029] Take 0.1g of Degussa P25 titanium dioxide, grind it in a mortar for 1 hour, add 1 ml of 1% acetic acid dropwise during the grinding process, disperse the ground titanium dioxide powder in 1 ml of ethanol, and dilute it 25 times in water to obtain 4 Milligrams per milliliter of titanium dioxide suspension. The suspension is modified on the glass surface using inkjet printing technology to form an array chip. The chip was burned at 400 degrees Celsius for one hour and then naturally cooled.
[0030] 0.4 millimoles per liter, 1 microliter of mitoxantrone aqueous solution was dropped on the surface of the glass plate modified with titanium dioxide, and it was directly detected by electrostatic spray ionization mass spectrometry. The square wave pulse high voltage used in the detection was 0- 6 kV, 100 Hz. Get as figure 2 In the spectrum shown, the peak with a mass-to-charge ratio of 445 is the peak of protonation of mitoxantrone.
[0031] The glass slide with mitoxantrone and modified with titanium dioxide was irradiated under an ultraviolet lamp, and different time points were used for electrostatic spray ionization mass spectrometry detection. The square wave pulse high voltage used in the detection was 0-6 kV. 100 Hz. Get as image 3 In the spectrum shown, the peaks with mass-to-charge ratios of 442, 443, 459, 475, 489 are the protonation peaks of the intermediates of the photocatalytic oxidation product of mitoxantrone. Among them, A is the mass spectrum of mitoxantrone in the electrostatic spray ionization mass spectrum after being irradiated with a UV lamp for 1 minute, B is the mass spectrum of mitoxantrone in the electrostatic spray ionization mass spectrum after being irradiated by a UV lamp for 3 minutes, and C is The mass spectrum of mitoxantrone in electrostatic spray ionization mass spectrometry after 5 minutes of ultraviolet lamp irradiation, and the mass spectrum of mitoxantrone in electrostatic spray ionization mass spectrometry after ultraviolet lamp irradiation for 10 minutes.

Example Embodiment

[0032] Example 2
[0033] A graphene-modified polyimide array chip was used in conjunction with electrostatic spray ionization mass spectrometry to detect the intermediates of the photooxidation reaction of mitoxantrone.
[0034] Graphene oxide ink formula: Add 3 mg of graphene oxide flakes (Nanjing Xianfeng Nano Material Technology Co., Ltd.) and 50 mg of polyvinylpyrrolidone (PVP) powder to 1 ml of water: isopropanol (3:1) mixture, and Ultrasound in an on/off cycle with an amplitude of 35% in a 2 ml centrifuge tube for 180 minutes. The final dispersion concentration is 3 mg/ml graphene oxide. Then, put the dispersion in a centrifuge at 13000 g Centrifuge for 20 minutes and remove the supernatant. Thereafter, the precipitate was redispersed in 1 ml of 1,2-propanediol-based mixture, which contained 10% terpineol.
[0035] An inkjet printer was used to print the above ink on the surface of a polyimide substrate (0.2 mm thickness) to form an array of dots with a diameter of 0.2 mm, and the printing layer was stabilized by light curing.
[0036] Drop 0.4 millimoles per liter, 1 microliter of mitoxantrone aqueous solution on the polyimide array chip modified with graphene oxide, and directly detect it by electrostatic spray ionization mass spectrometry. The square wave used in the detection The pulse high voltage is 0-6 kV, 100 Hz. A peak with a mass-to-charge ratio of 445 was detected, which is a peak of protonation of mitoxantrone.
[0037] The polyimide array chip with mitoxantrone and modified with graphene oxide was irradiated under an ultraviolet lamp, and the electrostatic spray ionization mass spectrometry was performed at different time points within 0-30 minutes. The square wave pulse high voltage is 0-6 kV, 100 Hz. The peaks at 442 and 443 are the protonation peaks of the intermediates of the photocatalytic oxidation product of mitoxantrone.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Thickness10.0µm
Thickness100.0µm
Diameter0.2mm
tensileMPa
Particle sizePa
strength10

Description & Claims & Application Information

We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Similar technology patents

Train-ground data communication method

Owner:INST OF COMPUTING TECH CHINA ACAD OF RAILWAY SCI +2

Method for sending information in a telecommunication system

InactiveUS6870876B1Fast estimationAvoid delayHybrid switching systemsTime-division multiplexTransceiverDigital signal
Owner:TELEFON AB LM ERICSSON (PUBL)

Classification and recommendation of technical efficacy words

Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products