Preparation method and applications of chitosan polypeptide derivative self-cross-linking hydrogel taking oxidized hyaluronic acid as cross-linking agent

A technology for oxidizing hyaluronic acid and chitosan polypeptides, applied in the field of polymer chemistry, can solve problems such as hindering development and poor solubility, and achieve the effects of no biological toxicity, excellent swelling performance, and good blood compatibility.
CN111019162AInactive Publication Date: 2020-04-17WUHAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV OF TECH
Publication Date
2020-04-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of polymer chemistry, and particularly relates to a preparation method and applications of a chitosan polypeptide derivative self-cross-linking hydrogel taking oxidized hyaluronic acid as a cross-linking agent. The preparation method comprises the following steps: (1) preparing oxidized hyaluronic acid; (2) preparing carboxymethyl chitosan; (3) preparing carboxymethyl chitosan / collagen peptide; and (4) respectively preparing a carboxymethyl chitosan / collagen peptide solution and an oxidized hyaluronic acid solution, uniformly mixing at a certain temperature,and carrying out self-cross-linking to obtain the hydrogel. According to the preparation method, the grafting reaction of carboxymethyl chitosan and collagen peptide is catalyzed by using transglutaminase as a catalyst, so that the process is simple, the reaction conditions are mild, the covalent bonds formed by the catalytic reaction are firm, the biotoxicity is avoided, the repeatability is good, and good economic value is achieved.
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Description

technical field

[0001] The invention belongs to the field of polymer chemistry, and in particular relates to a preparation method and application of chitosan polypeptide derivative self-crosslinking hydrogel with oxidized hyaluronic acid as a crosslinking agent. Background technique

[0002] Hydrogel is a polymer material that can swell in water but is insoluble in water. Through intermolecular cross-linking, a three-dimensional network structure is formed, and its molecular chain has hydrophilic groups. With the development of modern science and technology, hydrogels have many applications in the fields of controlled release of drugs, tissue engineering, and regeneration of organs. Hydrogel dressing is a new type of medical dressing that is similar to the extracellular matrix of human tissue and has good biocompatibility. The surface of the hydrogel dressing is soft, easy to fit the wound well, can provide a good moist healing environment for the wound, can absorb the exud...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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