A kind of fullerene derivative and its preparation method and application
A fullerene derivative, fullerene technology, applied in the field of fullerenes, can solve the problems of low fullerene efficiency, hinder application, cytotoxicity, etc., and achieve wide and convenient biological applications, mild conditions, and simple steps. Effect
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[0034] The preparation method of the fullerene derivative provided by the present invention comprises mixing fullerene F with unsaturated fatty acid and / or oil containing unsaturated fatty acid, the way and condition of the mixing make any carbon-carbon double in unsaturated fatty acid The σ and π bonds on the bond are broken and bonded to the carbon atoms of the fullerene F skeleton, and then a gel substance is separated from the obtained product, and the product obtained after the gel substance is optionally dried is the fullerene ene derivatives; the unsaturated fatty acid is represented by A=B, = represents any carbon-carbon double bond on the unsaturated fatty acid, A and B represent the groups at both ends of the above-mentioned carbon-carbon double bond, and A is C 3 -C 10 The hydrocarbyl group optionally substituted by fullerene F, B is C 5 -C 20 carboxyl group. After the double bond is broken, A and B are bonded to the carbon atom of the fullerene F to obtain the a...
Embodiment 1
[0047] Example 1 Fullerene Derivative F(M) n preparation of
[0048] The fullerene (C 60 ) into olive oil according to the ratio in Table 1, stirred evenly at -5°C to react the two, and then separated the gel substance from the reacted oil (the separation method was distillation, and the separation solvent used was DMSO ), and the fullerene derivative F1 was obtained after drying. The fullerene derivatives were detected by infrared, mass spectrometry and elemental analysis, the results are as follows:
[0049] Infrared detection: the following four characteristic peaks appeared in the infrared spectrum, CH 3 (1378cm -1 ), CH 2 (723cm -1 ), CH (1467cm -1 ), fullerene C=C (1950cm -1 ).
[0050] Mass spectrometry detection: a characteristic peak appeared at 973.5197m / z.
[0051] Elemental analysis: C: 96.32%, H: 3.81%.
[0052] It can be seen that the fullerene derivative does have F(M) n structure, where F is C 60 , M is CH(CH 2 ) 7 CH 3 , n is 2.
Embodiment 2
[0053] Example 2 Fullerene Derivative F(M) n preparation of
[0054] The fullerene (C 60 ) was added to the unsaturated fatty acid (linoleic acid) according to the ratio in Table 1, and the two were reacted by ball milling at 0°C, and then the gel substance was separated from the reacted oil (the separation method was extraction, the adopted The separation solvent is toluene, and the specific process is as follows: add the reacted oil and toluene into a separatory funnel for extraction at a volume ratio of 1:3, take the middle layer after static layering, and place the middle layer in a round bottom flask to rotate The solvent is distilled off, and the precipitate remaining at the bottom of the flask is the target product), and the powder obtained after drying is the fullerene derivative F2. The fullerene derivatives were detected by infrared, mass spectrometry and elemental analysis, the results are as follows:
[0055] Infrared detection: The following four characteristic...
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