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Controllably removed strong adhesion type hydrogel and preparation method thereof

A hydrogel and adhesive technology, which is applied in the field of preparation of strong adhesive multifunctional hydrogel, can solve the problems of shortening the recovery time, hindering the integration of gel materials and the surface of biological tissues, etc., to achieve enhanced adhesion Force and cohesion, good biocompatibility and biodegradability, good wet adhesion

Active Publication Date: 2020-04-24
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the existing hydrogel materials are only suitable for bonding under dry conditions, and the "hydrogen bond failure effect" caused by the humid physiological environment and the inherent high water content of hydrogels seriously hinders the bonding of gel materials. The integration of biological tissue surface and other issues, provide a preparation method of hydrogel adhesive with strong adhesion performance in wet environment, sutureless wound closure can simplify surgical procedures and shorten recovery time

Method used

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  • Controllably removed strong adhesion type hydrogel and preparation method thereof
  • Controllably removed strong adhesion type hydrogel and preparation method thereof

Examples

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example example 1

[0016] Gelatin was dissolved in PBS solution at 50°C to make a 10% w / v homogeneous solution. Then add 100 mg dopamine per gram of gelatin to the gelatin solution and stir evenly, then add 6 mg of genipin per gram of gelatin to the mixed solution at a rate of 0.5 mL / min, and keep stirring. The mixture was reacted at 37 °C for 6 h. Dialyze the gelatin solution against deionized water for 3 days using an 8-14 kDa cut-off dialysis bag to remove unreacted dopamine, genipin and any by-products. Freeze-dried for later use. The second network-hyaluronic acid was prepared by a two-step method. First, hyaluronic acid (1 g) and succinic anhydride (180 mg) were reacted in distilled water (100 mL) for 24 h to prepare hyaluronic acid succinate, which was dialyzed against deionized water for 3 hours using a 2 kDa cut-off dialysis bag. sky. N-Hydroxysuccinimide (200 mg) was then dissolved in distilled water (100 mL). The system was stirred at 37 °C for 24 h, and dialyzed against deionize...

example example 2

[0018] Gelatin was dissolved in PBS solution at 50°C to make a 10% w / v homogeneous solution. Then, 200 mg of dopamine per gram of gelatin was added to the gelatin solution and stirred evenly, and then 12 mg of genipin per gram of gelatin was added to the mixed solution at a rate of 0.5 mL / min, and the stirring was continued. The mixture was reacted at 50 °C for 12 h. Dialyze the gelatin solution against deionized water for 3 days using an 8-14 kDa cut-off dialysis bag to remove unreacted dopamine, genipin and any by-products. Freeze-dried for later use. The second network-hyaluronic acid was prepared by a two-step method. First, hyaluronic acid succinic acid was prepared by reacting hyaluronic acid (1 g) and succinic anhydride (180 mg) in distilled water (100 mL) for 24 h, and dialyzed against deionized water for 3 days using a 2 kDa cut-off dialysis bag . N-Hydroxysuccinimide (436 mg) was then dissolved in distilled water (100 mL). The system was stirred at 37 °C for 24 ...

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Abstract

A multifunctional hydrogel adhesive having excellent wet adhesion and being able to be rapidly degraded and controllably removed consists of two parts, namely double networks, wherein the first network is gelatin containing a catechol group, and the second network is hyaluronic acid containing a succinimide succinate group. The two components are mixed in a PBS solution to obtain the hydrogel. Once the hydrogel is in contact with tissue, succinimide succinate groups and catechol groups remained in the networks react with amino groups on tissue proteins, and the chemical bonds enable the firm connection strength between the tissues and the hydrogel to be higher than that of commercial fibrin glue. A cyclized succinate group is introduced into a hydrogel matrix, so that the hydrogel has thecharacteristics of rapid degradation and controllable removal.

Description

technical field [0001] The invention relates to medical gelatin hydrogel, and also relates to a preparation method of the strongly adhesive multifunctional hydrogel. Background technique [0002] Uncontrolled bleeding and wound infection has been one of the leading causes of death in the medical field. Improper wound management not only prolongs healing time, but also increases the risk of infection, the possibility of death, and the financial burden. The traditional way to stop bleeding is to apply cotton gauze to the wound, but the gauze absorbs blood and causes inevitable blood loss. At the same time, the absorbed blood will form a tight whole with the gauze, which will cause wound tearing, secondary bleeding and even infection during the process of removing the gauze. Bioadhesive is a biomedical material that can fill, seal, stop bleeding and bond wounds. It not only has the bonding performance of general adhesives, but also has many functions to meet biomedical applic...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08L5/08C08H1/00C08B37/08A61L24/08A61L24/10A61L24/00
CPCC08J3/075C08H1/00C08B37/0072A61L24/08A61L24/104A61L24/0031A61L24/0042A61L24/001C08J2389/00C08J2405/08A61L2400/04C08L5/08
Inventor 罗晓民霍倩倩刘新华冯见艳张鹏郑驰刘颖王怡然
Owner SHAANXI UNIV OF SCI & TECH
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