Nano capsule coated with dimethyl octyl p-aminobenzoate
A technology of octyl dimethyl p-aminobenzoate and nanocapsules, which is applied in skin care preparations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of low SPF, safety and cost, and additive dosage Large and other problems, achieve the effect of high SPF value, good safety, and increase compactness
Active Publication Date: 2020-04-28
苏州绿叶日用品有限公司
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- Application Information
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Problems solved by technology
Sunscreen products In order to obtain high UV protection sunscreen with an SPF value of 20 or more, the amount of sunscreen agent is often added in a large amount, which has caused problems in terms of safety and cost
Moreover, uncoated organic UV sunscreens are currently used in most sunscreen products, which have the problem of greater irritation to the skin
Dimethyl-octyl p-aminobenzoate, which belongs to oil-soluble ultraviolet absorber, is a safe and effective sunscreen, but when used alone, the additive dosage is large, which is potentially dangerous to the skin. When the additive dosage is small, the SPF is low
At present, there are related studies on the use of polymers to coat organic UV absorbers, which can improve their safety, but there are disadvantages such as easy leakage of sunscreens and low SPF.
Method used
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Embodiment 1
[0037] A polymer emulsifier P(St-co-MAA) with n(St):n(MAA)=6:4 was synthesized by free radical polymerization, and 1g of polymer emulsifier was weighed and dissolved in 0.1M NaOH aqueous solution and stirred overnight , After being completely dissolved, neutralize it with dilute acid and set the volume in a 100mL volumetric flask to prepare a 1% polymer emulsifier solution. Weigh 0.0336g MMA and crosslinking agent 0.2664g EGDMA (molar ratio 1:4) and mix with 0.3g octyl dimethyl p-aminobenzoate as the oil phase, and the water phase is 60ml 1% polymer emulsifier solution. The two phases were combined and then pre-emulsified with continuous stirring for 1 hour in the dark. Immediately after the pre-emulsification was completed, ultrasonic fine emulsification was carried out in an ultrasonic breaker (300W, 2 minutes) to obtain an O / W fine emulsion. Transfer the obtained O / W miniemulsion to a 100ml three-neck flask, add AIBN (3% of the molar weight of the monomer), deoxygenate wit...
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Abstract
The invention discloses a nano capsule coated with dimethyl octyl p-aminobenzoate. The nano capsule provided by the invention comprises a dimethyl octyl p-aminobenzoate nano capsule core, a nano capsule wall and an outer layer film, wherein the nano capsule wall covers the nano capsule core and is formed by polymerizing a methyl methacrylate monomer and an ethylene glycol dimethacrylate crosslinking agent, and the outer layer film covers the nano capsule wall and is formed by self-assembling an amphiphilic random copolymer polystyrene-co-methacrylic acid. The nano capsule coated with dimethyloctyl p-aminobenzoate has an irregular spherical structure, and the polymer emulsifier participates in forming a shell layer, so that compactness of a shell layer of the microcapsule is improved, andthe nano capsule does not leak in a common cosmetic solvent (such as isopropyl myristate). The nano capsule has a high sun protection factor (SPF) value and good safety.
Description
technical field [0001] The invention relates to a nanocapsule coated with octyl dimethyl p-aminobenzoate, which belongs to the technical field of sunscreen cosmetics. Background technique [0002] The amount of ultraviolet radiation continues to increase with the destruction of the ozone layer, and long-term exposure of the skin in such an environment may cause serious damage. Sunscreen products In order to obtain a high UV protection sunscreen with an SPF value above 20, the amount of sunscreen agent is often added in a large amount, which has caused problems in terms of safety and cost. Moreover, currently most sunscreen products use uncoated organic UV sunscreens, which have the problem of greater irritation to the skin. Dimethyl-octyl p-aminobenzoate, which belongs to oil-soluble ultraviolet absorber, is a safe and effective sunscreen, but when used alone, the additive dosage is large, which is potentially dangerous to the skin. When the additive dosage is small, the SP...
Claims
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IPC IPC(8): A61K8/81A61K8/11A61K8/44A61Q17/04
CPCA61K8/445A61K8/8147A61K8/8152A61K8/11A61Q17/04A61K2800/56A61K2800/413Y02A50/30
Inventor 刘冬张云
Owner 苏州绿叶日用品有限公司