Materials, methods and applications for preparing absorbable biorepair bone wax

Abstract

The present application discloses a material, method and application for preparing absorbable biorepair bone wax. The absorbable biorepair bone wax provided by the application is to physically co-polymerize mineralized collagen, chitosan, calcium sulfate and water in proportions of 20-45wt%, 10-20wt%, 10-30wt%, and 5-30wt%. Mixed, preferably, the mineralized collagen is hydroxyapatite-collagen complex. The bone wax provided by this application can be used for hemostasis on bone wounds, especially cancellous bone wounds. It has the advantages of convenient use, arbitrary shaping, fast filling of wound cracks, good adhesion, hemostasis can be gradually degraded and absorbed, and has no toxic and side effects on the human body. , can replace traditional bone wax.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a material, method and application for preparing absorbable biorepair bone wax. Background technique [0002] The structure of cancellous bone is loose and the blood supply is rich. The wound bleeding is mostly oozing blood. It is difficult to stop bleeding by vasoconstriction, and it is also difficult to stop bleeding by conventional methods such as electrocoagulation, forceps, hemostatic gauze, and gelatin sponge packing. The most effective method is to quickly fill the cracks on the surface of cancellous bone, stop the bleeding process, and then activate the intravascular and extravascular coagulation pathways to achieve hemostasis. The most clinically used bone wax is used for hemostasis of cancellous bone wounds. [0003] Bone wax, the main component of which is beeswax, is generally composed of beeswax and vaseline. It can physically block the capillary bleeding in the bone marr...

AI Technical Summary

Problems solved by technology

Bone wax has poor biocompatibility and is difficult to be degraded and absorbed by the matrix. If it remains locally, it will cause great obstacles to bone healing. Therefore, it is only a mechanical physical barrier, which will hinder the accumulation of blood components and is not conducive to the formation of original callus. Lead to poor bone healing, even osteonecrosis, affecting bone regeneration

In addition, because bone wax cannot be degraded and absorbed, it will remain in the body as a foreign body for a long time, forming foreign body granuloma, causing local pain, exudate and other symptoms, which not only reduces the anti-infection ability of the tissue, but also increases the risk of postoperative infection. probability

[0004] Some researchers have tried to replace traditional bone wax with oxidized cellulose, polylactic acid or polysaccharides. Although these materials have good biocompatibility and can be degraded and absorbed, most of them are in the form of powder or jelly, and their hemostatic mechanism is sticky. Aggregated platelets form thrombus to stop bleeding, while spongy bone wound bleeding is not only due to the loose tissue structure of the bone wound, rich blood supply to form dense sinusoids, poor vasoconstriction in the tissue, platelet aggregation, blood clots are difficult to adhere to the wound, easy washed away by blood or body fluids

At the same time, due to the difficulty of modifying the physical properties of such materials and the high price, there is currently no suitable hemostatic material for bone wounds on the market.

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