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Biological cellulose composite gel material and application thereof as wound dressing

A technology of biological cellulose and composite gel, which is applied in the preparation of wound dressing products. In the field of new biocellulose composite gel materials, it can solve the problems of limiting cell adhesion and proliferation, and the application limitation of biological cellulose. Achieve the effects of promoting adhesion and proliferation, promoting wound healing, and high water content

Active Publication Date: 2020-05-12
HAINAN GUANGYU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the relatively dense spatial structure of biocellulose hydrogel, it is not easily absorbed by the human body, and its dense grid often limits cell adhesion and proliferation during use.
This limits the application of biocellulose in wound dressings

Method used

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  • Biological cellulose composite gel material and application thereof as wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Preparation example 1 of composite gel material

[0025] 1) Preparation of biocellulose hydrogel film by static fermentation method: use coconut water culture medium, gluconoacetobacter xylinum, ferment culture in a shallow plate at 28°C for 7 days, and collect biocellulose hydrogel film on the liquid surface . After cleaning and purification, it is ready for use;

[0026] 2) The biocellulose hydrogel membrane was dehydrated by mechanical pressure to a water content of 60%, then soaked in 0.7wt% globulin solution, ultrasonically oscillated for 6 hours, taken out and washed with water;

[0027] 3) Take 0.05M sodium chloride solution, adjust the pH value to 4 with dilute hydrochloric acid, heat to 80°C, then immerse the biocellulose hydrogel film obtained in step 2) and heat it for 5 hours;

[0028] 4) Take it out and wash it with clean water.

[0029] That is, the composite gel material in the present invention is obtained.

Embodiment 2 ： preparation example 2

[0031] 1) Preparation of biocellulose hydrogel film by static fermentation method: using artificially prepared medium, Gluconoacetobacter xylinum, cultured in a shallow plate at 29°C for 9 days, and collecting the biocellulose hydrogel film on the liquid surface . After cleaning and purification, it is ready for use;

[0032] 2) The biocellulose hydrogel membrane was dehydrated to a water content of 40% by mechanical pressure, then soaked in 1wt% ovalbumin solution, ultrasonically oscillated for 8 hours, taken out and washed with water;

[0033] 3) Take 0.2M calcium chloride solution, adjust the pH value to 5 with dilute hydrochloric acid, heat to 70°C, then immerse the biocellulose hydrogel film obtained in step 2), and heat for 4 hours;

[0034] 4) Take it out and wash it with clean water.

Embodiment 3

[0035] Embodiment 3: Preparation example 3 of composite gel material

[0036] 1) Preparation of biocellulose hydrogel by shaking table dynamic fermentation method: use artificially prepared medium, Acetobacter xylinum, and shake table dynamic fermentation culture at 27°C for 5 days, collect biocellulose hydrogel, wash and purify for backup use;

[0037] 2) The collected biocellulose hydrogel was pressed into a film by mechanical pressure, and dehydrated to a water content of 70%, then soaked in a 3wt% soybean protein solution, ultrasonically oscillated for 16 hours, taken out and washed with water;

[0038] 3) Take 0.1M sodium chloride solution, adjust the pH value to 3 with dilute hydrochloric acid, heat to 65°C, then immerse the biocellulose hydrogel film obtained in step 2), and heat for 6 hours;

[0039] 4) Take it out and wash it with clean water.

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Abstract

The invention relates to a novel biological cellulose composite gel material and novel application thereof in preparing a wound dressing product. The composite gel provided by the invention is prepared by compounding a biological cellulose hydrogel with a protein thixotropic gel. The biological cellulose hydrogel is high in water content and good in water retention, and in addition, has sufficientmechanical strength. A protein gel is formed in a biological cellulose spatial structure, and is capable of maintaining the spatial structure of the biological cellulose hydrogel and promoting cell adhesion and multiplication. In addition, the protein thixotropic gel can be also formed and mechanically pressed before or in use, so that the protein thixotropic gel can be converted into a protein sol from the protein gel, and cell adhesion and multiplication can be further promoted, globulin which is not converted into a gel can be slowly released, the antibacterial and anti-inflammation properties of a dressing can be further improved, and wound healing can be promoted.

Description

technical field [0001] The application relates to a new material, in particular to a new biological cellulose composite gel material and its new application in preparing wound dressing products. Background technique [0002] Wound dressings usually refer to wound dressings, which are used to cover wounds or other wounds, protect the wound, resist external mechanical, pollution and chemical stimuli, prevent secondary infection, prevent dryness, loss of body fluids and heat loss. Traditional wound dressings are mainly dry gauze and oil gauze. However, dry gauze cannot be used for infected wounds, as it does not promote wound healing, has limited ability to manage exudate, and will adhere to the wound, which will cause re-damage to the new epithelial tissue and cause bleeding. Oil gauze contains petroleum jelly or triglycerides, which can play a role in non-adhesive wounds, but it also does not promote wound healing and has limited ability to manage exudate. Modern medicine h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0052A61L26/0061A61L26/0066A61L2300/252A61L2300/404A61L2300/41A61L2300/412C08L89/00C08L1/02
Inventor 钟春燕钟宇光
Owner HAINAN GUANGYU BIOTECH
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