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Rabdosia japonica glycoprotein XPS5-1 as well as preparation method and application thereof

A technology of blue calyx and glycoprotein, which is applied to the preparation method of peptides, peptide/protein components, chemical instruments and methods, etc., and can solve the problems of few reports on macromolecular components

Active Publication Date: 2020-05-15
SHANGAI PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the chemical constituents of S. indigo is also mainly focused on small molecules, such as diterpenes, triterpenes, flavonoids, organic acids, sterols and other components isolated from S. Medium and macromolecular components are rarely reported

Method used

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  • Rabdosia japonica glycoprotein XPS5-1 as well as preparation method and application thereof
  • Rabdosia japonica glycoprotein XPS5-1 as well as preparation method and application thereof
  • Rabdosia japonica glycoprotein XPS5-1 as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0035] Materials: 5.0 kg of blue calyx fragrant tea (batch number: SPHTCMXCC01) was obtained from Fengyang, Anhui (collected on November 20, 2015), DEAE Sepharose Fast Flow anion exchange resin and Superdex series molecular sieve gel columns were purchased from General Electric GE Healthcare; Pullulan P-82 standard set: P-5, P-10, P-20, P-50, P-100, P-200, P-400, P-800, Shodex; water is Ultrapure water (self-made in the laboratory); ascorbic acid, tryptophan, methylene blue, Catalase, dimethylaminobenzaldehyde, trichloroacetic acid, monosaccharide standard (D-glucose, D-arabinose, L-fucose , L-rhamnose, D-mannose, D-xylose, D-galactose) and trifluoroacetic acid were purchased from SIGMA; TDO enzyme and NLG-919 were purchased from MCE; 384-well compound plates were purchased from Nunc ; Ethanol and sodium chloride were purchased from Sinopharm Group Shanghai Reagent Co., Ltd., 95% ethanol refers to ethanol with a volume fraction of 95%; other reagents were of analytical grade. ...

preparation Embodiment 2

[0042] Taking different batches of S. japonica (batch number: SPHTCMXCC02), the extraction and separation and purification methods of Preparation Example 1 were repeated to obtain the S. sativa polysaccharide XPS5-1 of Preparation Example 2.

preparation Embodiment 3

[0044] Taking different batches of S. japonica (batch number: SPHTCMXCC03), the extraction and separation and purification methods of Preparation Example 1 were repeated to obtain the S. sativa polysaccharide XPS5-1 of Preparation Example 3.

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Abstract

The invention discloses rabdosia japonica glycoprotein XPS5-1 which comprises polysaccharides and proteins, wherein monosaccharide composition of the polysaccharides comprises rhamnose, glucose and arabinose; and amino acid composition of the proteins comprises glutamatic acid, serine and glycine. The invention further provides a preparation method and application of the rabdosia japonica glycoprotein XPS5-1. The rabdosia japonica glycoprotein XPS5-1 can be adopted to prepare a tryptophan 2,3-dioxygenase inhibitor.

Description

technical field [0001] The invention relates to the field of extracting plants; in particular, it relates to a calyx calyx glycoprotein XPS5-1, its preparation method and application. Background technique [0002] Rabdosia japonica (Burm.f.) Hara is the original variety of Rabdosia japonica (Burm.f. Hara), which is a plant of the genus Isodon in the family Labiatae. Weifuchun Tablets is a pure traditional Chinese medicine preparation developed by Hu Qingyutang, a subsidiary of Shanghai Pharmaceutical Group. One of the main sources of medicinal materials of Weifuchun Zhongxiang tea. Weifuchun Tablets can invigorate the spleen and replenish qi, promote blood circulation and detoxify, and treat the early lesions of gastric cancer. . Weifuchun Tablet is the only national protected traditional Chinese medicine approved by the drug supervision department in China for the treatment of gastric precancerous lesions. In view of the good efficacy of Weifuchun Tablets, the material ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/415C07K1/36C07K1/30C07K1/18C07K1/16A61K38/16A61P35/00
CPCC07K14/415A61P35/00A61K38/00
Inventor 王辉俊刘彦君叶冠
Owner SHANGAI PHARMA GRP CO LTD
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